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Showing 1–5 of 5 results
Advanced filters: Author: Helga Grötsch Clear advanced filters

  • Functional mutations identified in patients with androgen insensitivity syndrome, in the formin and actin nucleator DAAM2, uncover signal-regulated nuclear actin assembly at a steroid hormone receptor necessary for transcription.

    • Julian Knerr
    • Ralf Werner
    • Nadine C. Hornig
    Research
    Nature
    Volume: 617, P: 616-622

  • Transcription factor TFIIIC plays roles in Pol III transcription and in chromatin organization. CryoEM structure of the yeast TFIIIC subcomplex τA, a negative stain reconstruction of τA bound to the TFIIIB subunits Brf1 and TBP and accompanying biochemistry suggest how τA achieves positioning of TFIIIB upstream of the TSS and remodeling of the TFIIIC complex during assembly of TFIIIB.

    • Matthias K. Vorländer
    • Anna Jungblut
    • Christoph W. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-12

  • Many chromatin modifying proteins, including BRDT, contain bromodomains, which are known to interact with nucleosomes. Here, the authors find that BRDT interacts with nucleosomes via only one of its two bromodomains, and that the interaction involves contacts with DNA as well as acetylated histones.

    • Thomas C. R. Miller
    • Bernd Simon
    • Christoph W. Müller
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Here the authors structurally investigate elongating human RNA polymerase I at 2.7 Å using cryo-electron microscopy, as well as an RNA polymerase I open complex at 3.3 Å and bound to initiation factor RRN3 at 3.2 Å.

    • Agata D. Misiaszek
    • Mathias Girbig
    • Christoph W. Müller
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 28, P: 997-1008

  • Cryo-EM structures of human Pol III in both apo- and elongating states reveal metazoan-specific differences in the regulation of transcription termination and identify mutations relevant to human disease.

    • Mathias Girbig
    • Agata D. Misiaszek
    • Christoph W. Müller
    Research
    Nature Structural & Molecular Biology
    Volume: 28, P: 210-219