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Advanced filters: Author: Henri-Alexandre Michaud Clear advanced filters

E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development

The mechanisms by which pyruvate metabolism defects lead to neurological symptoms in Leigh syndrome patients remain unclear. Here, the authors show a link between pyruvate metabolism and translation fidelity that is important for brain development.

Michela Di Michele
Aurore Attina
Laurent Le Cam
ResearchOpen Access02 Jan 2025
Nature Communications

Volume: 16, P: 1-17
First-line durvalumab and tremelimumab with chemotherapy in RAS-mutated metastatic colorectal cancer: a phase 1b/2 trial

Treatment with anti-PDL1 and anti-CTLA4 in combination with mFOLFOX6 chemotherapy for patients with treatment-naive microsatellite stable metastatic colorectal cancer is safe, shows encouraging progression-free survival and induces a tumor-specific immune response.

Marion Thibaudin
Jean-David Fumet
François Ghiringhelli
ResearchOpen Access10 Aug 2023
Nature Medicine

Volume: 29, P: 2087-2098
ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment

Marine Bruciamacchie
Véronique Garambois
Christel Larbouret
Research29 Nov 2024
British Journal of Cancer

Volume: 132, P: 222-235

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