Nature Search

Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration

Isao Hara
Hiroshi Nagai
Sadao Kamidono
Research18 May 2000
Cancer Gene Therapy

Volume: 7, P: 83-90
Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

Hideaki Miyake
Norihisa Hanada
Hideyuki Saya
Research03 Mar 1998
Oncogene

Volume: 16, P: 933-943
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
Dianionic species with a bond consisting of two pentacoordinated silicon atoms

Silicon, like carbon, favours a four-coordinate geometry and this underpins the frameworks of the wide range of inorganic and organosilicon compounds, from silicate minerals to polysilanes. Although some pentavalent silicon compounds have already been reported, this work presents the first example where two five-coordinate silicon atoms are bonded to each other.

Naokazu Kano
Hideaki Miyake
Shigeru Nagase
Research17 Jan 2010
Nature Chemistry

Volume: 2, P: 112-116
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550

Hideaki Ui
Kazuro Shiomi
Satoshi Ōmura
Research01 Sept 2006
The Journal of Antibiotics

Volume: 59, P: 591-596
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Sulphate–climate coupling over the past 300,000 years in inland Antarctica

Profiles of sulphate fluxes over the past 300,000 years from an Antarctic ice core show that, whereas the flux of sulphate-adhered dust has remained almost constant, that of sulphate salts correlates inversely with temperature, suggesting a coupling between particulate sulphur and temperature.

Yoshinori Iizuka
Ryu Uemura
Takeo Hondoh
Research03 Oct 2012
Nature

Volume: 490, P: 81-84
Novel EXOSC9 variants cause pontocerebellar hypoplasia type 1D with spinal motor neuronopathy and cerebellar atrophy

Masamune Sakamoto
Kazuhiro Iwama
Naomichi Matsumoto
Research10 Oct 2020
Journal of Human Genetics

Volume: 66, P: 401-407
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Investigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration

Hideaki Oiwa
Hideshi Okada
Shinji Ogura
ResearchOpen Access05 Oct 2023
Scientific Reports

Volume: 13, P: 1-7
Microarray comparative genomic hybridization (CGH)-based prenatal diagnosis for chromosome abnormalities using cell-free fetal DNA in amniotic fluid

Shoko Miura
Kiyonori Miura
Tadayuki Ishimaru
Research01 May 2006
Journal of Human Genetics

Volume: 51, P: 412-417
SWCNT Photocatalyst for Hydrogen Production from Water upon Photoexcitation of (8, 3) SWCNT at 680-nm Light

Noritake Murakami
Yuto Tango
Yutaka Takaguchi
ResearchOpen Access06 Mar 2017
Scientific Reports

Volume: 7, P: 1-7
Asynchrony between Antarctic temperature and CO₂ associated with obliquity over the past 720,000 years

The Antarctic temperature record displays a puzzling asynchrony with changes in CO₂ through glacial cycles. Here, the authors show that a 720,000-year Antarctic temperature record is affected by variations in obliquity-induced local insolation that are associated with phase modulation of eccentricity cycle.

Ryu Uemura
Hideaki Motoyama
Yoshiyuki Fujii
ResearchOpen Access06 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan

Hidehiko Miyake
Shigehito Yamada
Koji Kugu
Research30 Jun 2016
Journal of Human Genetics

Volume: 61, P: 879-884
Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan

Hidehiko Miyake
Shigehito Yamada
Koji Kugu
Amendments and Corrections23 Aug 2018
Journal of Human Genetics

Volume: 63, P: 1195
Sema3a maintains normal heart rhythm through sympathetic innervation patterning

Masaki Ieda
Hideaki Kanazawa
Keiichi Fukuda
Research08 Apr 2007
Nature Medicine

Volume: 13, P: 604-612
PSA doubling time 4.65 months as an optimal cut-off of Japanese nonmetastatic castration-resistant prostate cancer

Shinichi Sakamoto
Kodai Sato
Hiroshi Kitamura
ResearchOpen Access03 Jul 2024
Scientific Reports

Volume: 14, P: 1-11
Efficacy and safety of second-line cabozantinib after immuno-oncology combination therapy for advanced renal cell carcinoma: Japanese multicenter retrospective study

Tomokazu Sazuka
Yuto Matsushita
Tomohiko Ichikawa
ResearchOpen Access23 Nov 2023
Scientific Reports

Volume: 13, P: 1-10
Coexistence of superconductivity and charge-density wave in the quasi-one-dimensional material HfTe₃

Saleem J. Denholme
Akinori Yukawa
Nobuaki Miyakawa
ResearchOpen Access24 Mar 2017
Scientific Reports

Volume: 7, P: 1-6
A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer

Ruhan A
Hideto Ueki
Toshiro Shirakawa
ResearchOpen Access26 Feb 2025
Cancer Gene Therapy

Volume: 32, P: 306-317
Apatite coating on dendrimer-modified buckypaper and the formation of nanoapatite on MWCNTs

Multi-walled carbon nanotube (MWCNT)/dendrimer sheet scaffolds, i.e., dendrimers attached to the surface of MWCNT buckypaper, were fabricated, and a hydroxyapatite (HAp) coating prepared on dendrimer-modified buckypaper using an alternate soaking process (ASP) is described. The amount of the HAp that is retained on the surface of the MWCNT/dendrimer sheet scaffolds depends on the dendrimer contents. Moreover, biomimetic crystallization of calcium phosphate on buckypaper in simulated body fluid (SBF) was carried out. TEM analysis of the resulting MWCNT/dendrimer sheet scaffolds revealed that the MWCNT backbone was covered with scaly crystals.

Tomoyuki Tajima
Tomoaki Tanaka
Yutaka Takaguchi
Research01 May 2018
Polymer Journal

Volume: 50, P: 911-917
Postoperative bacteriuria, pyuria and urinary tract infection in patients with an orthotopic sigmoid colon neobladder replacement

Katsumi Shigemura
Kazushi Tanaka
Masato Fujisawa
Research30 Oct 2013
The Journal of Antibiotics

Volume: 67, P: 143-145
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

Hirotomo Saitsu
Miho Watanabe
Naomichi Matsumoto
ResearchOpen Access20 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Assessments of therapeutic effects according to timings for combined therapy with axitinib and immune check point inhibitor in a mouse renal cell carcinoma model

Hiromitsu Watanabe
Yuto Matsushita
Hideaki Miyake
ResearchOpen Access13 Jul 2023
Scientific Reports

Volume: 13, P: 1-10
Tunable spin-valley coupling in layered polar Dirac metals

Spin-orbit coupling in non-centrosymmetric crystals gives rise to interesting spin-momentum locking of the Fermi surface. Here, the electronic structure of polar metals BaMnX₂ (X = Bi, Sb) reveals a high sensitivity to X sublattice distortions, resulting in a chemically tunable spin-valley coupling of Dirac fermions.

Masaki Kondo
Masayuki Ochi
Hideaki Sakai
ResearchOpen Access14 May 2021
Communications Materials

Volume: 2, P: 1-7
Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

Ryo Kamidani
Takahito Miyake
Shinji Ogura
ResearchOpen Access16 Sept 2021
Scientific Reports

Volume: 11, P: 1-9
A variant at 9q34.11 is associated with HLA-DQB1*06:02 negative essential hypersomnia

Taku Miyagawa
Seik-Soon Khor
Katsushi Tokunaga
Research28 Sept 2018
Journal of Human Genetics

Volume: 63, P: 1259-1267
Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Takeru Amiya
Nobuhiro Nakamoto
Takanori Kanai
ResearchOpen Access11 Oct 2016
Scientific Reports

Volume: 6, P: 1-12
Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7–PAK1 complex

Hideaki Ito
Takumi Tsunoda
Kenji Kasai
Research21 Nov 2019
Oncogene

Volume: 39, P: 1931-1943
Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation

Ikuko Haruta
Ken Kikuchi
Junji Yagi
Research08 Feb 2010
Laboratory Investigation

Volume: 90, P: 577-588

Search

Effectiveness of cancer vaccine therapy using cells transduced with the interleukin-12 gene combined with systemic interleukin-18 administration

Overexpression of Bcl-2 in bladder cancer cells inhibits apoptosis induced by cisplatin and adenoviral-mediated p53 gene transfer

Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

Dianionic species with a bond consisting of two pentacoordinated silicon atoms

Blood DNA virome associates with autoimmune diseases and COVID-19

Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550

The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

DOCK2 is involved in the host genetics and biology of severe COVID-19

Sulphate–climate coupling over the past 300,000 years in inland Antarctica

Novel EXOSC9 variants cause pontocerebellar hypoplasia type 1D with spinal motor neuronopathy and cerebellar atrophy

Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Investigation of the relationship between intradialytic hypotension during hemodialysis and serum syndecan-1 concentration

Microarray comparative genomic hybridization (CGH)-based prenatal diagnosis for chromosome abnormalities using cell-free fetal DNA in amniotic fluid

SWCNT Photocatalyst for Hydrogen Production from Water upon Photoexcitation of (8, 3) SWCNT at 680-nm Light

Asynchrony between Antarctic temperature and CO₂ associated with obliquity over the past 720,000 years

Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan

Correction: Nationwide survey for current clinical status of amniocentesis and maternal serum marker test in Japan

Sema3a maintains normal heart rhythm through sympathetic innervation patterning

PSA doubling time 4.65 months as an optimal cut-off of Japanese nonmetastatic castration-resistant prostate cancer

Efficacy and safety of second-line cabozantinib after immuno-oncology combination therapy for advanced renal cell carcinoma: Japanese multicenter retrospective study

Coexistence of superconductivity and charge-density wave in the quasi-one-dimensional material HfTe₃

A conditionally replicative adenovirus vector containing the synNotch receptor gene for the treatment of muscle-invasive bladder cancer

Apatite coating on dendrimer-modified buckypaper and the formation of nanoapatite on MWCNTs

Postoperative bacteriuria, pyuria and urinary tract infection in patients with an orthotopic sigmoid colon neobladder replacement

Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

Assessments of therapeutic effects according to timings for combined therapy with axitinib and immune check point inhibitor in a mouse renal cell carcinoma model

Tunable spin-valley coupling in layered polar Dirac metals

Effect of cryoprecipitate transfusion therapy in patients with postpartum hemorrhage: a retrospective cohort study

A variant at 9q34.11 is associated with HLA-DQB106:02* negative essential hypersomnia

Bone marrow-derived macrophages distinct from tissue-resident macrophages play a pivotal role in Concanavalin A-induced murine liver injury via CCR9 axis

Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7–PAK1 complex

Long-term bacterial exposure can trigger nonsuppurative destructive cholangitis associated with multifocal epithelial inflammation

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