Generating mice lacking protein kinase N1 (PKN1), Yasuda et al. find that PKN1 loss leads to abnormal input-nonspecific mGluR-dependent long-term depression. The authors also observe reduced glutamate uptake and immature synaptic transmission, suggesting an important role for PKN1 in synapse maturation.
- Hiroki Yasuda
- Hikaru Yamamoto
- Hideyuki Mukai
