Nature Search

The power of genetic diversity in genome-wide association studies of lipids

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Research09 Dec 2021
Nature

Volume: 600, P: 675-679
BLOOD PRESSURE MONITORING IN NEONATES: COMPARISON OF UMBILICAL AND PERIPHERAL ARTERY PRESSURE MEASUREMENTS

Warwick Butt
Hilary Whyte
Research01 Apr 1984
Pediatric Research

Volume: 18, P: 314
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent risk loci. Comparisons with other psychiatric disorders and candidate gene analyses provide new insights into major depressive disorder.

Naomi R. Wray
Stephan Ripke
Patrick F. Sullivan
Research26 Apr 2018
Nature Genetics

Volume: 50, P: 668-681
Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

Walter Kahr and colleagues report mutations in NBEAL2 in gray platelet syndrome (GPS). Using RNA-seq, the authors observed abnormal pre-mRNA processing in NBEAL2 in platelets from an individual with GPS.

Walter HA Kahr
Jesse Hinckley
Jorge Di Paola
Research17 Jul 2011
Nature Genetics

Volume: 43, P: 738-740
Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Sarah E. Graham
Shoa L. Clarke
Cristen J. Willer
Amendments and Corrections26 May 2023
Nature

Volume: 618, P: E19-E20
Neurexin 1 variants as risk factors for suicide death

Nancy William
Carsten Reissner
Hilary Coon
ResearchOpen Access25 Jun 2021
Molecular Psychiatry

Volume: 26, P: 7436-7445
Identification of common genetic risk variants for autism spectrum disorder

A genome-wide-association meta-analysis of 18,381 austim spectrum disorder (ASD) cases and 27,969 controls identifies five risk loci. The authors find quantitative and qualitative polygenic heterogeneity across ASD subtypes.

Jakob Grove
Stephan Ripke
Anders D. Børglum
Research25 Feb 2019
Nature Genetics

Volume: 51, P: 431-444
Advancing the science of headwater streamflow for global water protection

Despite their substantial contributions to watershed resilience, headwater streams are becoming increasingly imperilled. This Perspective summarizes the status of headwater streamflow information and proposes guidance for advancing the understanding of headwater hydrology to support better management of these systems.

Heather E. Golden
Jay R. Christensen
Frederick Cheng
Reviews02 Jan 2025
Nature Water

Volume: 3, P: 16-26
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Depression is correlated with many brain-related traits. Here, Shen et al. perform phenome-wide association studies of a depression polygenic risk score (PRS) and find associations with 51 behavioural and 26 neuroimaging traits which are further followed up on using Mendelian randomization and mediation analyses.

Xueyi Shen
David M. Howard
Andrew M. McIntosh
ResearchOpen Access08 May 2020
Nature Communications

Volume: 11, P: 1-16
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Environmental influences during prenatal development may have implications for health and disease later in life. Here, Czamara et al. assess DNA methylation in cord blood from new-born under various models including environmental and genetic effects individually and their additive or interaction effects.

Darina Czamara
Gökçen Eraslan
Elisabeth B. Binder
ResearchOpen Access11 Jun 2019
Nature Communications

Volume: 10, P: 1-18
IPCRG Consensus statement: Tackling the smoking epidemic — practical guidance for primary care

Onno CP van Schayck
Hilary Pinnock
Hakan Yaman
Reviews05 Sept 2008
Primary Care Respiratory Journal

Volume: 17, P: 185-193
Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide

Hilary Coon
Todd M. Darlington
Douglas Gray
ResearchOpen Access23 Oct 2018
Molecular Psychiatry

Volume: 25, P: 3077-3090
Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes

Seonggyun Han
Emily DiBlasi
Hilary Coon
ResearchOpen Access04 Oct 2023
Molecular Psychiatry

Volume: 28, P: 3909-3919
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Sarah M. C. Colbert
Eric T. Monson
Lea Zillich
ReviewsOpen Access25 Sept 2025
Molecular Psychiatry

Volume: 30, P: 6144-6154
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Amendments and Corrections18 May 2020
Molecular Psychiatry

Volume: 26, P: 5465

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The power of genetic diversity in genome-wide association studies of lipids

BLOOD PRESSURE MONITORING IN NEONATES: COMPARISON OF UMBILICAL AND PERIPHERAL ARTERY PRESSURE MEASUREMENTS

Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome

Author Correction: The power of genetic diversity in genome-wide association studies of lipids

Neurexin 1 variants as risk factors for suicide death

Identification of common genetic risk variants for autism spectrum disorder

Advancing the science of headwater streamflow for global water protection

A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank

Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

IPCRG Consensus statement: Tackling the smoking epidemic — practical guidance for primary care

Genome-wide significant regions in 43 Utah high-risk families implicate multiple genes involved in risk for completed suicide

Whole-genome sequencing analysis of suicide deaths integrating brain-regulatory eQTLs data to identify risk loci and genes

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Defining suicidality phenotypes for genetic studies: perspectives of the Psychiatric Genomics Consortium Suicide Working Group

Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

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