Nature Search

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment

Wnt signaling is activated in more than half of gastric cancers through a ligand-dependent manner. Here the authors show with mouse models that tumor-derived Wnt ligands activate liver stromal fibroblasts to facilitate hyaluronan accumulation in the microenvironment, promoting gastric cancer liver metastasis.

Yuichiro Furutani
Hiroko Oshima
Masanobu Oshima
ResearchOpen Access14 Feb 2026
Nature Communications

P: 1-16
Severe Combined Immunodeficiency in a Child with a Healthy Adenosine Deaminase Deficient Mother

Frank C Schmalstieg
Gordon C Mills
Armond S Goldman
Research01 Dec 1983
Pediatric Research

Volume: 17, P: 935-940
963 IMMUNODEFICIENCY IN A CHILD WITH A HEALTHY ADENOSINE DEAMINASE DEFICIENT MOTHER

Frank C Schmalstieg
Hiroko Tsuda
Armond S Goldman
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 603
Two-Step Imprinting Procedure of Inter-Penetrating Polymer Network-Type Stimuli-Responsive Hydrogel-Adsorbents

Keiji Yamashita
Takashi Nishimura
Mamoru Nango
Research01 Jul 2003
Polymer Journal

Volume: 35, P: 545-550
Promoter Hypermethylation of the RB1 Gene in Glioblastomas

Mitsutoshi Nakamura
Yasuhiro Yonekawa
Hiroko Ohgaki
Research01 Jan 2001
Laboratory Investigation

Volume: 81, P: 77-82
Unfavorable switching of skewed X chromosome inactivation leads to Menkes disease in a female infant

Ayumi Matsumoto
Shintaro Kano
Sadahiko Iwamoto
ResearchOpen Access03 Jan 2024
Scientific Reports

Volume: 14, P: 1-9
A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector

Junpei Ohtsuka
Masayuki Fukumura
Tetsuya Nosaka
ResearchOpen Access09 Sept 2019
Scientific Reports

Volume: 9, P: 1-9
Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Shun Kodate
Mitsuharu Sato
Kengo Kinoshita
ResearchOpen Access16 May 2025
Scientific Reports

Volume: 15, P: 1-11
Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Cancer cell clusters metastasize to distant organ by polyclonal manner. Here, the authors show that malignant subclone induces fibrotic niche generation in the liver by hepatic stellate cell activation, supporting survival and colonization of non-metastatic cells to develop polyclonal metastasis.

Sau Yee Kok
Hiroko Oshima
Masanobu Oshima
ResearchOpen Access08 Feb 2021
Nature Communications

Volume: 12, P: 1-14
Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties

Both gain-of-function of mutant p53 (GOF) and loss of wild-type p53 (LOH) are independently associated with cancer. Here, the authors show that LOH promotes GOF tumourigenesis by increasing tumor-initiating ability and metastasis.

Mizuho Nakayama
Chang Pyo Hong
Masanobu Oshima
ResearchOpen Access11 May 2020
Nature Communications

Volume: 11, P: 1-14
Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Aye Ko Ko Minn
Motomichi Matsuzaki
Gen Tamiya
ResearchOpen Access03 Apr 2025
Journal of Human Genetics

Volume: 70, P: 287-296
Three-dimensional imaging of ferroaxial domains using circularly polarized second harmonic generation microscopy

Hiroko Yokota
Takeshi Hayashida
Tsuyoshi Kimura
ResearchOpen Access03 Nov 2022
npj Quantum Materials

Volume: 7, P: 1-6
AXIN1 mutations but not deletions in cerebellar medulloblastomas

Nathalie Baeza
Jun Masuoka
Hiroko Ohgaki
Research29 Jan 2003
Oncogene

Volume: 22, P: 632-636
Increased Expression of Human 63-kD Heat Shock Protein Gene in Kawasaki Disease Determined by Quantitative Reverse Transcription-Polymerase Chain Reaction

Sehchiro Takeshita
Hiroko Kawase
Shigetake Yoshioka
Research01 Feb 1994
Pediatric Research

Volume: 35, P: 179-182
Insufficient social support for fathers of children with developmental disorders

Shiori Ishida
Hiromi Okuno
Hiroko Takahashi
ResearchOpen Access07 Jan 2022
Humanities and Social Sciences Communications

Volume: 9, P: 1-8
Mutations in the STK11 Gene Characterize Minimal Deviation Adenocarcinoma of the Uterine Cervix

Chie Kuragaki
Takayuki Enomoto
Shingo Fujii
Research01 Jan 2003
Laboratory Investigation

Volume: 83, P: 35-45
Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

Yukari Yada
Akihide Ohkuchi
Mariko Hida
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-13
FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells

Toshikatsu Tsuji
Yusuke Maeda
Hiroko Oshima
ResearchOpen Access01 Apr 2021
Oncogene

Volume: 40, P: 3072-3086
NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells

Kanae Echizen
Keigo Horiuchi
Masanobu Oshima
ResearchOpen Access30 Jan 2019
Oncogene

Volume: 38, P: 4250-4263
Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Ryohei Yamamoto
Enyu Imai
Hiroyuki Komatsu
ResearchOpen Access13 Jun 2022
Scientific Reports

Volume: 12, P: 1-12
Development and validation of a prediction model for bronchopulmonary dysplasia using respiratory severity score

Takahiro Kanzawa
Fumie Kinoshita
Ryo Tanaka
ResearchOpen Access03 Feb 2025
Pediatric Research

Volume: 98, P: 577-584

Search

Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment

Severe Combined Immunodeficiency in a Child with a Healthy Adenosine Deaminase Deficient Mother

963 IMMUNODEFICIENCY IN A CHILD WITH A HEALTHY ADENOSINE DEAMINASE DEFICIENT MOTHER

Two-Step Imprinting Procedure of Inter-Penetrating Polymer Network-Type Stimuli-Responsive Hydrogel-Adsorbents

Promoter Hypermethylation of the RB1 Gene in Glioblastomas

Unfavorable switching of skewed X chromosome inactivation leads to Menkes disease in a female infant

A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector

Simulating metabolic pathways to enhance interpretations of metabolome genome-wide association studies

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation

Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties

Profiling of runs of homozygosity from whole-genome sequence data in Japanese biobank

Three-dimensional imaging of ferroaxial domains using circularly polarized second harmonic generation microscopy

AXIN1 mutations but not deletions in cerebellar medulloblastomas

Increased Expression of Human 63-kD Heat Shock Protein Gene in Kawasaki Disease Determined by Quantitative Reverse Transcription-Polymerase Chain Reaction

Insufficient social support for fathers of children with developmental disorders

Mutations in the STK11 Gene Characterize Minimal Deviation Adenocarcinoma of the Uterine Cervix

Synergic interaction between ritodrine and magnesium sulfate on the occurrence of critical neonatal hyperkalemia: A Japanese nationwide retrospective cohort study

FOXO3 is a latent tumor suppressor for FOXO3-positive and cytoplasmic-type gastric cancer cells

NF-κB-induced NOX1 activation promotes gastric tumorigenesis through the expansion of SOX2-positive epithelial cells

Predictors of early remission of proteinuria in adult patients with minimal change disease: a retrospective cohort study

Development and validation of a prediction model for bronchopulmonary dysplasia using respiratory severity score

Search

Quick links

Search

Filter By:

Search

Quick links