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Scientific Reports (21)
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Showing 1–50 of 59 results

Advanced filters: Author: Hiroyuki Imamura Clear advanced filters

Zinc finger domains bind low-complexity domain polymers

Self-association of low-complexity protein sequences (LC domains) is important for polymer formation, but the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here, authors show that zinc finger domains bind LC domains in a cross-β polymer-dependent manner.

Naohiko Iguchi
Noriyoshi Isozumi
Eiichiro Mori
ResearchOpen Access16 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Effect of intrathecal nimodipine on spinal cord blood flow and evoked potentials in the normal or injured cord

Hiroyuki Imamura
Charles H Tator
Research07 Jun 1998
Spinal Cord

Volume: 36, P: 497-506
Deciphering state-dependent immune features from multi-layer omics data at single-cell resolution

A single-cell multiomic immune cell atlas from 235 Japanese, including patients with COVID-19 and healthy individuals, linked with host genetics including germline and somatic mutation, plasma proteomics and metagenomics data reveals that immune cells are dynamically regulated in a cell state-dependent manner.

Ryuya Edahiro
Go Sato
Yukinori Okada
ResearchOpen Access28 Jul 2025
Nature Genetics

Volume: 57, P: 1905-1921
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force

Genetic mechanisms influencing COVID-19 susceptibility are not well understood. Here, the authors analyzed whole blood RNA-seq data of 465 Japanese individuals with COVID-19, highlighting thousands of fine-mapped variants affecting expression and splicing of genes, as well as the presence of COVID-19 severity-interaction eQTLs.

Qingbo S. Wang
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access22 Aug 2022
Nature Communications

Volume: 13, P: 1-19
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Blood DNA virome associates with autoimmune diseases and COVID-19

Analysis of the blood DNA virome in patients with COVID-19 and autoimmune disease associates endogenous HHV-6 (eHHV-6) and high anellovirus load with increased disease risk, most notably for systemic lupus erythematosus. eHHV-6 carriers show a distinct immune response.

Noah Sasa
Shohei Kojima
Yukinori Okada
ResearchOpen Access03 Jan 2025
Nature Genetics

Volume: 57, P: 65-79
Ab initio Molecular Orbital Calculations for the Double-Stranded Helices of Poly(methyl methacrylate) Monomer Model

Hiroshi Kusanagi
Yozo Chatani
Hiroyuki Tadokoro
Research01 Jul 1996
Polymer Journal

Volume: 28, P: 639-640
Isolation and characterization of a novel actin filament-binding protein from Saccharomyces cerevisiae

Takeshi Asakura
Takuya Sasaki
Yoshimi Takai
Research21 Jan 1998
Oncogene

Volume: 16, P: 121-130
Single-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity

Peripheral blood mononuclear cells from 73 Japanese patients with coronavirus disease 2019 (COVID-19) and 75 healthy controls were analyzed using single-cell transcriptomics. Combining these data with genotyping data highlights the interplay between host genetics and the immune response in modulating disease severity.

Ryuya Edahiro
Yuya Shirai
Yukinori Okada
ResearchOpen Access24 Apr 2023
Nature Genetics

Volume: 55, P: 753-767
Long-term survival evaluation after transcatheter aortic valve implantation in patients with severe aortic valve stenosis: a retrospective cohort study

Kiyoshi Takemoto
Tomoya Myojin
Tomoaki Imamura
ResearchOpen Access01 Apr 2025
Scientific Reports

Volume: 15, P: 1-9
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Deep sequencing reveals variations in somatic cell mosaic mutations between monozygotic twins with discordant psychiatric disease

Yoshiro Morimoto
Shinji Ono
Naohiro Kurotaki
ResearchOpen Access27 Jul 2017
Human Genome Variation

Volume: 4, P: 1-6
Identification and characterization of a novel enhancer in the HTLV-1 proviral genome

Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic virus with constantly active antisense transcription from the proviral genome. Here, Matsuo et al. perform proviral DNA-capture followed by high-throughput sequencing and identify a yet unknown viral enhancer in the middle of the HTLV-1 provirus.

Misaki Matsuo
Takaharu Ueno
Yorifumi Satou
ResearchOpen Access03 May 2022
Nature Communications

Volume: 13, P: 1-16
Nrp2 is sufficient to instruct circuit formation of mitral-cells to mediate odour-induced attractive social responses

Neuropilin 2 (Nrp2) is expressed by a subset of mitral cells in the postero-ventral olfactory bulb in mice. Here the authors show that Nrp2 is sufficient to instruct mitral cell targeting to the anterior part of medial amygdala that modulates olfactory-driven attractive social behaviour.

Kasumi Inokuchi
Fumiaki Imamura
Hitoshi Sakano
ResearchOpen Access21 Jul 2017
Nature Communications

Volume: 8, P: 1-13
A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model

Amyotrophic lateral sclerosis (ALS) is a neurological disease that leads to loss of voluntary muscle movement. Here, the authors screen for molecules that disrupt interaction between SOD1, a protein linked to ALS, and Derlin-1, and find an inhibitor that reduces pathology in an ALS mouse model.

Naomi Tsuburaya
Kengo Homma
Hidenori Ichijo
ResearchOpen Access10 Jul 2018
Nature Communications

Volume: 9, P: 1-12
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Detailed deletion mapping suggests the involvement of a tumor suppressor gene at 17p13.3, distal to p53, in the pathogenesis of lung cancers

Hiroyuki Konishi
Takao Takahashi
Takashi Takahashi
Research21 Oct 1998
Oncogene

Volume: 17, P: 2095-2100
Resolving stepping rotation in Thermus thermophilus H⁺-ATPase/synthase with an essentially drag-free probe

Rotary ATPases F_oF₁ and V_oV₁ couple ATP hydrolysis with proton flow. Furuike et al. observe ATP-driven rotation in V₁ and V_oV₁, at submillisecond resolution, and find that rate-limiting reactions in V₁ all occur at the same angle, and stator–rotor interactions in V_ointroduce additional checkpoints.

Shou Furuike
Masahiro Nakano
Ken Yokoyama
ResearchOpen Access08 Mar 2011
Nature Communications

Volume: 2, P: 1-9
Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant

In vitro studies in human cell lines and in vivo studies in a hamster model show that the SARS-CoV-2 Omicron variant is less pathogenic than both the Delta variant and an ancestral strain of SARS-CoV-2.

Rigel Suzuki
Daichi Yamasoba
Kei Sato
ResearchOpen Access01 Feb 2022
Nature

Volume: 603, P: 700-705
Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping

Expression of Cas9 and gRNA from viral vectors in vivo may cause off-target activity. Here the authors present NanoMEDIC, which uses nanovesicles to transiently deliver editing machinery to hard-to-transfect cells.

Peter Gee
Mandy S. Y. Lung
Akitsu Hotta
ResearchOpen Access13 Mar 2020
Nature Communications

Volume: 11, P: 1-18
Reevaluating the therapeutic role of extended lymph node dissection in the era of robot-assisted radical prostatectomy

Atsuro Sawada
Koshiro Nishimoto
Takahiro Inoue
ResearchOpen Access21 May 2025
Scientific Reports

Volume: 15, P: 1-13
Recurrent SPI1 (PU.1) fusions in high-risk pediatric T cell acute lymphoblastic leukemia

Junko Takita, Seishi Ogawa and colleagues profile 121 cases of pediatric T cell acute lymphoblasic leukemia (T-ALL) and identify recurrent SPI1 (PU.1) gene fusions. They find that these SPI1 fusions correlated with poor survival, retained transcriptional activity and, in a mouse stem cell model, enhanced cell proliferation.

Masafumi Seki
Shunsuke Kimura
Junko Takita
Research03 Jul 2017
Nature Genetics

Volume: 49, P: 1274-1281
Direct reprogramming of mouse fibroblasts into self-renewable alveolar epithelial-like cells

Atsuho Morita
Makoto Ishii
Koichi Fukunaga
ResearchOpen Access23 Jun 2025
npj Regenerative Medicine

Volume: 10, P: 1-16
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Growth retardation and adult height in pediatric patients with chronic-phase chronic myeloid leukemia treated with tyrosine kinase inhibitors

Haruko Shima
Chikako Tono
Hiroyuki Shimada
Research12 Dec 2024
Leukemia

Volume: 39, P: 508-511
Impact of aspirin on biochemical recurrence of prostate cancer after robot assisted radical prostatectomy in a multicenter retrospective cohort study

Shuhei Suzuki
Hiromitsu Negoro
Takashi Kobayashi
ResearchOpen Access15 Jan 2025
Scientific Reports

Volume: 15, P: 1-10
Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Left atrial scRNA-seq from patients with atrial fibrillation (AF) reveals macrophage heterogeneity and identifies monocytes and IL1B⁺ macrophages as key sources of EGF signals to fibroblasts, with serum AREG emerging as a biomarker for persistent AF.

Yuya Suzuki
Takuo Emoto
Koji Fukuzawa
ResearchOpen Access02 Dec 2024
Communications Biology

Volume: 7, P: 1-13
Comparative analysis of necrotizing enterocolitis in preterm infants born in Japan and born to mothers of Japanese ethnicity in California

Satoshi Kusuda
Mihoko V. Bennett
Asao Yara
ResearchOpen Access22 Mar 2025
Scientific Reports

Volume: 15, P: 1-11
Non-invasive SARS-CoV-2 RNA detection and human transcriptome analysis using skin surface lipids

Tetsuya Kuwano
Takayuki Kanno
Tadaki Suzuki
ResearchOpen Access30 Oct 2024
Scientific Reports

Volume: 14, P: 1-8
Author Correction: Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Yuya Suzuki
Takuo Emoto
Koji Fukuzawa
Amendments and CorrectionsOpen Access26 May 2025
Communications Biology

Volume: 8, P: 1
Therapeutic hypothermia for neonatal encephalopathy: a report from the first 3 years of the Baby Cooling Registry of Japan

Kennosuke Tsuda
Takeo Mukai
Kayo Yoshikawa
ResearchOpen Access04 Jan 2017
Scientific Reports

Volume: 7, P: 1-10
Quantifying physical insights cooperatively with exhaustive search for Bayesian spectroscopy of X-ray photoelectron spectra

Hiroyuki Kumazoe
Kazunori Iwamitsu
Ichiro Akai
ResearchOpen Access14 Aug 2023
Scientific Reports

Volume: 13, P: 1-12
HOPS-R01 phase II trial evaluating neoadjuvant S-1 therapy for resectable pancreatic adenocarcinoma

Toru Nakamura
Tsuyoshi Hayashi
Akinobu Taketomi
ResearchOpen Access15 Jun 2022
Scientific Reports

Volume: 12, P: 1-9
Pressure-independent effects of pharmacological stimulation of soluble guanylate cyclase on fibrosis in pressure-overloaded rat heart

Hiroyuki Masuyama
Toshihiro Tsuruda
Kazuo Kitamura
Research08 May 2009
Hypertension Research

Volume: 32, P: 597-603
Visualization of epithelial-mesenchymal transition in an inflammatory microenvironment–colorectal cancer network

Takeshi Ieda
Hiroshi Tazawa
Toshiyoshi Fujiwara
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-11
GVHD-free, relapse-free survival provides novel clues for optimizing allogeneic-HSCT for adult T-cell leukemia/lymphoma

Hiroyuki Muranushi
Takero Shindo
Koji Kato
Research14 Jul 2020
Bone Marrow Transplantation

Volume: 56, P: 155-166
Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging

Hideyuki Yaginuma
Shinnosuke Kawai
Hiromi Imamura
ResearchOpen Access06 Oct 2014
Scientific Reports

Volume: 4, P: 1-7
Effects of thienopyridine class antiplatelets on bleeding outcomes following robot-assisted radical prostatectomy

Masashi Kubota
Mutsushi Kawakita
Takayuki Goto
ResearchOpen Access11 Mar 2024
Scientific Reports

Volume: 14, P: 1-10
Resistance exercise has an antihypertensive effect comparable to that of aerobic exercise in hypertensive patients: a meta-analysis of randomized controlled trials

These authors contributed equally to this work:

Hidetaka Morita
Makiko Abe
Shin-ichiro Miura
Research28 Nov 2024
Hypertension Research

Volume: 48, P: 733-743
Differences in the effects of exercise on blood pressure depending on the physical condition of the subject and the type of exercise: a systematic review and meta-analysis

Yasunori Suematsu
Hidetaka Morita
Shin-ichiro Miura
Research01 Nov 2024
Hypertension Research

Volume: 48, P: 720-732
A unique missense variant in the E1A-binding protein P400 gene is implicated in schizophrenia by whole-exome sequencing and mutant mouse models

Yoshiro Morimoto
Shinji Ono
Akira Imamura
ResearchOpen Access18 Feb 2021
Translational Psychiatry

Volume: 11, P: 1-12
Outcomes in high and low volume hospitals in patients with acute hematochezia in a cohort study

Naoki Ishii
Naoyoshi Nagata
Mitsuru Kaise
ResearchOpen Access13 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
A novel negative regulatory mechanism of Smurf2 in BMP/Smad signaling in bone

Junichi Kushioka
Takashi Kaito
Takeshi Imamura
ResearchOpen Access23 Nov 2020
Bone Research

Volume: 8, P: 1-10
Novel and potent antimicrobial effects of caspofungin on drug-resistant Candida and bacteria

Makoto Sumiyoshi
Taiga Miyazaki
Hiroshi Mukae
ResearchOpen Access20 Oct 2020
Scientific Reports

Volume: 10, P: 1-12
Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder

Yoshiro Morimoto
Mihoko Shimada-Sugimoto
Shinji Ono
ResearchOpen Access02 Feb 2018
Translational Psychiatry

Volume: 8, P: 1-8
Quasispecies of Hepatitis C Virus Participate in Cell-Specific Infectivity

Takasuke Fukuhara
Satomi Yamamoto
Yoshiharu Matsuura
ResearchOpen Access22 Mar 2017
Scientific Reports

Volume: 7, P: 1-10
Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE

Kentaro Masujin
Hiroyuki Okada
Takashi Yokoyama
ResearchOpen Access07 Mar 2016
Scientific Reports

Volume: 6, P: 1-10
Generation of transgenic cynomolgus monkeys that express green fluorescent protein throughout the whole body

Yasunari Seita
Tomoyuki Tsukiyama
Masatsugu Ema
ResearchOpen Access25 Apr 2016
Scientific Reports

Volume: 6, P: 1-13
Restoration of E-cadherin-based cell–cell adhesion by overexpression of nectin in HSC-39 cells, a human signet ring cell gastric cancer cell line

Ying-Feng Peng
Kenji Mandai
Yoshimi Takai
Research05 Jun 2002
Oncogene

Volume: 21, P: 4108-4119
5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy

Yasuhisa Sando
Ken-ichi Matsuoka
Yoshinobu Maeda
ResearchOpen Access14 Oct 2020
Scientific Reports

Volume: 10, P: 1-11

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