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Showing 1–50 of 75 results

Advanced filters: Author: Hisashi Ito Clear advanced filters

Natural variations at the Stay-Green gene promoter control lifespan and yield in rice cultivars

Breeding crops with delayed senescence could plausibly increase grain yield. Here the authors show that variation at the rice SGR locus contributes to differences in senescence between indica and japonica subspecies and show that introgression can increase yield in an elite indica rice variety.

Dongjin Shin
Sichul Lee
Hong Gil Nam
ResearchOpen Access04 Jun 2020
Nature Communications

Volume: 11, P: 1-11
Late fluid flow in a primitive asteroid revealed by Lu–Hf isotopes in Ryugu

Analysis of samples from the asteroid Ryugu provide evidence of late fluid flow in a carbonaceous asteroid, indicating that such bodies may have retained two to three times more water than previously thought.

Tsuyoshi Iizuka
Takazo Shibuya
Hisayoshi Yurimoto
Research10 Sept 2025
Nature

Volume: 646, P: 62-67
Molecular diversity of the NMDA receptor channel

Tatsuya Kutsuwada
Nobuko Kashiwabuchi
Masayoshi Mishina
Research02 Jul 1992
Nature

Volume: 358, P: 36-41
Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly

Hiromi Ito
Akihiko Kameyama
Hisashi Narimatsu
Research27 May 2007
Nature Methods

Volume: 4, P: 577-582
Associations of family history of hypertension, genetic, and lifestyle risks with incident hypertension

Masato Takase
Takumi Hirata
Masayuki Yamamoto
ResearchOpen Access13 Aug 2025
Hypertension Research

Volume: 48, P: 2606-2617
Tissue factor pathway inhibitor 2 (TFPI2) is a potential serum biomarker for clear cell renal carcinoma

Hiroki Ito
Ryosuke Jikuya
Kazuhide Makiyama
ResearchOpen Access19 Nov 2024
Scientific Reports

Volume: 14, P: 1-9
The involvement of calpain-independent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas

Yoriyoshi Kimura
Hisashi Koga
Mitsuyoshi Nakao
Research01 Aug 1998
Nature Medicine

Volume: 4, P: 915-922
Impact of the “L” score from the RENAL nephrometry score on RAPN surgical outcomes in medial versus lateral renal tumors

Yasuhiro Numata
Hiroki Ito
Kazuhide Makiyama
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-9
Enhancement of aflatoxin B1-induced enzyme altered hepatic foci in rats by treatment with carbon tetrachloride

Guozhong Qin
Yaoyu Ning
Prabhakar D Lotlikar
ResearchOpen Access01 Dec 1998
Experimental & Molecular Medicine

Volume: 30, P: 186-191
Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

Hiroyuki Meguro
Hisashi Mori
Masayoshi Mishina
Research07 May 1992
Nature

Volume: 357, P: 70-74
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

A comparison of copper and zinc isotopic measurements between the Ryugu samples and various carbonaceous chondrites excludes any genetic link between the two except for the CI (Ivuna-type) chondrites. Ryugu-like material might have accounted for ~5% of Earth’s mass.

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Research12 Dec 2022
Nature Astronomy

Volume: 7, P: 182-189
Generation of hypoimmunogenic T cells from genetically engineered allogeneic human induced pluripotent stem cells

T cells derived from human induced pluripotent stem cells lacking certain components of the human leukocyte antigen system and incorporating a ligand that inhibits natural killer cells escape rejection when implanted in allogeneic mice.

Bo Wang
Shoichi Iriguchi
Shin Kaneko
Research17 May 2021
Nature Biomedical Engineering

Volume: 5, P: 429-440
Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α

Synaptic organizers are cell-adhesion molecules capable of inducing synaptic differentiation through transsynaptic interactions. Here the authors present the crystal structure of the intracellular interaction between the synaptic organizer PTPδ and Liprin-α to reveal the structural mechanism of intracellular molecular interactions for IIa-RPTP-mediated synapse formation.

Maiko Wakita
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access31 Jan 2020
Nature Communications

Volume: 11, P: 1-10
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)

Satoshi Umemura
Hisatomi Arima
Nobuhito Hirawa
Reviews02 Aug 2019
Hypertension Research

Volume: 42, P: 1235-1481
Association of social disengagement with health status and all-cause mortality among community-dwelling older adults: evidence from the Otassha study

Manami Ejiri
Hisashi Kawai
Shuichi Obuchi
ResearchOpen Access26 Oct 2022
Scientific Reports

Volume: 12, P: 1-7
A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated

Takahisa Takino
Katsuji Yoshioka
Hiroshi Sato
Research17 Sept 2002
Oncogene

Volume: 21, P: 6488-6497
Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation

Synaptic organizers are cell adhesion molecules that facilitate synapse formation through trans-synaptic interactions. Here the authors give molecular insights into synaptic differentiation by determining the structures of the synaptic adhesion-like molecules SALM2 and SALM5 bound to the presynaptic organizer PTPδ.

Sakurako Goto-Ito
Atsushi Yamagata
Shuya Fukai
ResearchOpen Access18 Jan 2018
Nature Communications

Volume: 9, P: 1-9
Production of 5-hydroxymethylfurfural from Japanese cedar (Cryptomeria japonica) in an ionic liquid, 1-methylimidazolium hydrogen sulfate

Ryoya Ito
Hisashi Miyafuji
ResearchOpen Access23 Nov 2021
Scientific Reports

Volume: 11, P: 1-9
Mechanisms of splicing-dependent trans-synaptic adhesion by PTPδ–IL1RAPL1/IL-1RAcP for synaptic differentiation

Synapse formation depends on trans-synaptic interactions between selective pairs of pre- and postsynaptic adhesion molecules. Here, the authors establish the basis for the splice isoform-dependent selectivity of receptor protein tyrosine phosphatase δ as it forms trans-synaptic contacts with IL1RAPL1 and IL-1RAcP.

Atsushi Yamagata
Tomoyuki Yoshida
Shuya Fukai
ResearchOpen Access24 Apr 2015
Nature Communications

Volume: 6, P: 1-11
ATP-dependent modulation of MgtE in Mg²⁺ homeostasis

MgtE is an Mg²⁺ transporter involved in Mg²⁺ homeostasis. Here, the authors report that ATP regulates the Mg⁺²-dependent gating of MgtE and use X-ray crystallography combined with functional studies to propose the molecular mechanisms involved in this process.

Atsuhiro Tomita
Mingfeng Zhang
Osamu Nureki
ResearchOpen Access27 Jul 2017
Nature Communications

Volume: 8, P: 1-11
Impact of TP53 immunohistochemistry on the histological grading system for endometrial endometrioid carcinoma

Mitsutake Yano
Kozue Ito
Masanori Yasuda
Research11 Feb 2019
Modern Pathology

Volume: 32, P: 1023-1031
Examination of the changes in lower extremities related to progression of adult spinal deformity: a longitudinal study of over 22 years

Mutsuya Shimizu
Tetsuya Kobayashi
Hiroshi Ito
ResearchOpen Access14 Jul 2020
Scientific Reports

Volume: 10, P: 1-9
Classification of arm swing as a clinical marker of advancing spinal deformity among community-dwelling female volunteers 60 years or older

Tetsuya Kobayashi
Shizuo Jimbo
P. T. Hisashi Chiba
ResearchOpen Access20 May 2019
Scientific Reports

Volume: 9, P: 1-6
Effects of lowering diastolic blood pressure to <80 mmHg on cardiovascular mortality and events in patients with coronary artery disease: a systematic review and meta-analysis

Ryuji Okamoto
Eita Kumagai
Hisatomi Arima
Research05 Apr 2019
Hypertension Research

Volume: 42, P: 650-659
Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations

Sohei Ito
David B. Graf
Hisashi Sawada
ResearchOpen Access13 May 2025
Scientific Reports

Volume: 15, P: 1-12
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Time-averaged disease activity fits better joint destruction in rheumatoid arthritis

Hideaki Tsuji
Koichiro Yano
Chikashi Terao
ResearchOpen Access19 Jul 2017
Scientific Reports

Volume: 7, P: 1-8
Impact of drainage retinotomy on surgical outcomes of retinal detachment: insights from the Japan-Retinal Detachment Registry

Hisashi Fukuyama
Hiroto Ishikawa
Shin Yamane
ResearchOpen Access02 Apr 2024
Scientific Reports

Volume: 14, P: 1-8
Author Correction: Contribution of Ryugu-like material to Earth’s volatile inventory by Cu and Zn isotopic analysis

Marine Paquet
Frederic Moynier
Hisayoshi Yurimoto
Amendments and Corrections14 Mar 2023
Nature Astronomy

Volume: 7, P: 633
Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction

Risa Shinoki
Ryosuke Jikuya
Hiroki Ito
ResearchOpen Access29 Jan 2025
Scientific Reports

Volume: 15, P: 1-9
Transferrin receptor 1 deficiency in smooth muscle cells attenuates vascular remodeling in hypertensive mice

Yoshiro Naito
Hisashi Sawada
Masaharu Ishihara
ResearchOpen Access09 Jun 2025
Hypertension Research

Volume: 48, P: 2263-2268
White matter microstructural changes in tuberous sclerosis: Evaluation by neurite orientation dispersion and density imaging (NODDI) and diffusion tensor images

Toshiaki Taoka
Noriko Aida
Shinji Naganawa
ResearchOpen Access16 Jan 2020
Scientific Reports

Volume: 10, P: 1-9
Enhancing the photovoltaic performance of hybrid heterojunction solar cells by passivation of silicon surface via a simple 1-min annealing process

Rongbin Xie
Naoya Ishijima
Suguru Noda
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-7
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia

Keisuke Okuno
Yoshiro Naito
Masaharu Ishihara
ResearchOpen Access20 Sept 2019
Scientific Reports

Volume: 9, P: 1-8
Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases

Takahisa Takino
Naohiko Koshikawa
Hiroshi Sato
Research24 Jul 2003
Oncogene

Volume: 22, P: 4617-4626
Diastolic Dysfunction in Hypertensive Hearts: Roles of Perivascular Inflammation and Reactive Myocardial Fibrosis

Hisashi Kai
Fumitaka Kuwahara
Tsutomu Imaizumi
Reviews01 Jun 2005
Hypertension Research

Volume: 28, P: 483-490
Human protein factory for converting the transcriptome into an in vitro–expressed proteome

A collection of 33,275 human Gateway entry clones and complementary in vitro protein expression methodologies are described that allow proteome-scale production of human proteins. This 'human protein factory' was validated by expression of 13,364 human proteins and assessment of activity in a variety of assays.

Naoki Goshima
Yoshifumi Kawamura
Nobuo Nomura
Research23 Nov 2008
Nature Methods

Volume: 5, P: 1011-1017
First-line osimertinib in elderly patients with epidermal growth factor receptor-mutated advanced non-small cell lung cancer: a retrospective multicenter study (HOT2002)

Gaku Yamamoto
Hajime Asahina
Hirotoshi Akita
ResearchOpen Access30 Nov 2021
Scientific Reports

Volume: 11, P: 1-11
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study

Kenya Kusunose
Hisako Yoshida
Mikiko Kagiyama
ResearchOpen Access17 Oct 2021
Hypertension Research

Volume: 45, P: 106-115
Gene expression profiles during tissue remodeling following bladder outlet obstruction

Saya Ito
Takeshi Nomura
Osamu Ukimura
ResearchOpen Access23 Jun 2021
Scientific Reports

Volume: 11, P: 1-9
Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells

Immune rejection may limit the therapeutic use of induced pluripotent stem cells (iPSCs); here, terminally differentiated mouse iPSCs are shown to generate negligible immune rejection in their host.

Ryoko Araki
Masahiro Uda
Masumi Abe
Research09 Jan 2013
Nature

Volume: 494, P: 100-104
Isolation of growth inhibitors of the snow rot pathogen Pythium iwayamai from an arctic strain of Trichoderma polysporum

Miyu Kamo
Motoaki Tojo
Tomoo Hosoe
Research06 Jan 2016
The Journal of Antibiotics

Volume: 69, P: 451-455
Failure to confirm association between PDCD1 polymorphisms and rheumatoid arthritis in a Japanese population

Takuji Iwamoto
Katsunori Ikari
Naoyuki Kamatani
Research28 Apr 2007
Journal of Human Genetics

Volume: 52, P: 557-560
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Impact of an unprecedented marine heatwave on extremely hot summer over Northern Japan in 2023

Hirotaka Sato
Kazuto Takemura
Hisashi Nakamura
ResearchOpen Access19 Jul 2024
Scientific Reports

Volume: 14, P: 1-14
Orthotopic transplantation of the bioengineered lung using a mouse-scale perfusion-based bioreactor and human primary endothelial cells

Fumiko Tomiyama
Takaya Suzuki
Yoshinori Okada
ResearchOpen Access04 Apr 2024
Scientific Reports

Volume: 14, P: 1-12
Macrophage depletion attenuates degeneration of spiral ganglion neurons in kanamycin-induced unilateral hearing loss model

Mari Dias Shimada
Masao Noda
Osamu Hori
ResearchOpen Access05 Oct 2023
Scientific Reports

Volume: 13, P: 1-9
Kerriamycin B inhibits protein SUMOylation

Isao Fukuda
Akihiro Ito
Minoru Yoshida
Research06 Mar 2009
The Journal of Antibiotics

Volume: 62, P: 221-224

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