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Showing 1–50 of 78 results

Advanced filters: Author: Hitoshi Hashimoto Clear advanced filters

Fas and Fas Ligand Gene Mutations in Hashimoto’s Thyroiditis

Zhiming Dong
Tetsuya Takakuwa
Katsuyuki Aozasa
Research01 Dec 2002
Laboratory Investigation

Volume: 82, P: 1611-1616
Thyroid Hormones in Human Milk and their Influence on Thyroid Function of Breast-Fed Babies

Hitoshi Mizuta
Nobuyuki Amino
Kiyoshi Miyai
Research01 Jun 1983
Pediatric Research

Volume: 17, P: 468-471
Seasonal variation of methylarsenic compounds in airborne participate matter

Hitoshi Mukai
Yoshinari Ambe
Tsuneo Fukuma
Research20 Nov 1986
Nature

Volume: 324, P: 239-241
Correction: Corrigendum: Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
Amendments and CorrectionsOpen Access20 Apr 2016
Nature Communications

Volume: 7, P: 1
Dissection of the polygenic architecture of neuronal Aβ production using a large sample of individual iPSC lines derived from Alzheimer’s disease patients

Using more than 100 independent iPSC lines derived from patients with Alzheimer’s disease, the authors discovered loci associated with the neuronal production of amyloid β and confirmed their influence using RNA interference.

Takayuki Kondo
Norikazu Hara
Haruhisa Inoue
Research17 Feb 2022
Nature Aging

Volume: 2, P: 125-139
DOCK2 is involved in the host genetics and biology of severe COVID-19

A genome-wide association study highlights a variant in DOCK2, which is common in East Asian populations but rare in Europeans, as a host genetic risk factor for severe COVID-19.

Ho Namkoong
Ryuya Edahiro
Yukinori Okada
ResearchOpen Access08 Aug 2022
Nature

Volume: 609, P: 754-760
Two novel mutations in the α-galactosidase gene in Japanese classical hemizygotes with Fabry disease

Toshika Okumiya
Toshihiro Takenaka
Hitoshi Sakuraba
Research01 Sept 1996
Japanese journal of human genetics

Volume: 41, P: 313-321
Point mutations of rhodopsin gene found in Japanese families with autosomal dominant retinitis pigmentosa (ADRP)

Keiko Fujiki
Yoshihiro Hotta
Atsushi Kanai
Research01 Jun 1992
Japanese journal of human genetics

Volume: 37, P: 125-132
Rapid and long-lasting antidepressant-like effects of the pituitary adenylate cyclase-activating polypeptide receptor antagonist PA-915 in chronic stress mouse models

Yusuke Shintani
Atsuko Hayata-Takano
Hitoshi Hashimoto
ResearchOpen Access04 Sept 2025
Molecular Psychiatry

P: 1-13
Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes

De novo mutations significantly contribute to autism spectrum disorders (ASD). Here, the authors demonstrate that ASD-associated de novo mutations in the POGZ gene, one of a high-confidence ASD gene, lead to ASD-related impaired neuronal development and disrupted mature cortical network function.

Kensuke Matsumura
Kaoru Seiriki
Takanobu Nakazawa
ResearchOpen Access26 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Emerging roles of ARHGAP33 in intracellular trafficking of TrkB and pathophysiology of neuropsychiatric disorders

The molecular mechanisms of neurotrophin receptor trafficking are only partially understood. Here the authors show that ARHGAP33 interacts with SORT1 to regulate TrkB trafficking, the dysfunction of which impairs synapse development and leads to schizophrenia-related behavioural abnormalities in mice.

Takanobu Nakazawa
Ryota Hashimoto
Masanobu Kano
ResearchOpen Access03 Feb 2016
Nature Communications

Volume: 7, P: 1-17
Identification and replication of sex-dimorphic protein quantitative trait loci across multiple ancestries and their associations with diseases

Youngjune Bhak
Vasilis Raptis
Albert Tenesa
ResearchOpen Access28 Aug 2025
Scientific Reports

Volume: 15, P: 1-16
Integrated exome and RNA sequencing of dedifferentiated liposarcoma

Understanding the genomic features of dedifferentiated liposarcoma (DDLPS) is likely to uncover new options for management. Here, the authors reveal three prognostic groups, and highlight molecular markers associated with malignant transformation.

Makoto Hirata
Naofumi Asano
Koichi Matsuda
ResearchOpen Access12 Dec 2019
Nature Communications

Volume: 10, P: 1-12
Activity-dependent organization of prefrontal hub-networks for associative learning and signal transformation

Neuronal populations in the prefrontal cortex are involved in associative learning. Here the authors use longitudinal imaging and computational approaches in the mouse prefrontal cortex to observe changes in neuronal ensembles during fear conditioning.

Masakazu Agetsuma
Issei Sato
Takeharu Nagai
ResearchOpen Access06 Oct 2023
Nature Communications

Volume: 14, P: 1-22
Ablation of PDK1 in pancreatic β cells induces diabetes as a result of loss of β cell mass

Naoko Hashimoto
Yoshiaki Kido
Masato Kasuga
Research23 Apr 2006
Nature Genetics

Volume: 38, P: 589-593
Changes in Hepatobiliary Enzyme Abnormality After the Great East Japan Earthquake: The Fukushima Health Management Survey

Atsushi Takahashi
Tetsuya Ohira
Masafumi Abe
ResearchOpen Access06 Apr 2017
Scientific Reports

Volume: 7, P: 1-9
A small number of abnormal brain connections predicts adult autism spectrum disorder

Autism spectrum disorder (ASD) is manifested by subtle but significant changes in the brain. Here, Yahata and colleagues devise a novel machine learning algorithm and develop a reliable ASD classifier based on brain functional connectivity, with which they quantitatively measure neuroimaging dimensions between ASD and other mental disorders.

Noriaki Yahata
Jun Morimoto
Mitsuo Kawato
ResearchOpen Access14 Apr 2016
Nature Communications

Volume: 7, P: 1-12
Wound healing responses of urinary extravasation after urethral injury

Taiju Hyuga
Kota Fujimoto
Gen Yamada
ResearchOpen Access30 Jun 2023
Scientific Reports

Volume: 13, P: 1-11
Anti-thyroid antibodies and thyroid echo pattern at baseline as risk factors for thyroid dysfunction induced by anti-programmed cell death-1 antibodies: a prospective study

Norio Okada
Shintaro Iwama
Hiroshi Arima
ResearchOpen Access03 Feb 2020
British Journal of Cancer

Volume: 122, P: 771-777
Intensive or standard blood pressure control in patients with a history of ischemic stroke: RESPECT post hoc analysis

A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

Kazuo Kitagawa
Hisatomi Arima
Seigo Nakada
Research04 Mar 2022
Hypertension Research

Volume: 45, P: 591-601
Parabrachial-to-parasubthalamic nucleus pathway mediates fear-induced suppression of feeding in male mice

Feeding and stress are deeply related to each other, yet neural circuits how they interact are not fully understood. Here, the authors show that the parabrachial-to-parasubthalamic nucleus pathway is involved in fear-induced feeding suppression.

Takashi Nagashima
Suguru Tohyama
Ayako M. Watabe
ResearchOpen Access30 Dec 2022
Nature Communications

Volume: 13, P: 1-17
GRK6 deficiency in mice causes autoimmune disease due to impaired apoptotic cell clearance

The clearance of apoptotic cells by macrophages is important for tissue homoeostasis. Here Nakaya et al. reveal a role for GRK6 in the regulation of apoptotic engulfment and show that GRK6 deficiency in mice leads to autoimmune disease and iron accumulation in the spleen.

Michio Nakaya
Mitsuru Tajima
Hitoshi Kurose
ResearchOpen Access26 Feb 2013
Nature Communications

Volume: 4, P: 1-11
Structured line illumination Raman microscopy

Raman imaging provides visualization of molecular content in a sample, but has been practically limited in resolution. Here, the authors implement structured line illumination in slit-scanning Raman microscopy, expanding its resolvable spatial frequencies without spoiling the advantage of the Raman approach.

Kozue Watanabe
Almar F. Palonpon
Katsumasa Fujita
ResearchOpen Access02 Dec 2015
Nature Communications

Volume: 6, P: 1-8
Association between pazopanib exposure and safety in Japanese patients with renal cell carcinoma or soft tissue sarcoma

Takeshi Aoyama
Kenji Nakano
Shunji Takahashi
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Automated detection of enlarged extraocular muscle in Graves’ ophthalmopathy with computed tomography and deep neural network

Kaori Hanai
Hitoshi Tabuchi
Masato Hashimoto
ResearchOpen Access26 Sept 2022
Scientific Reports

Volume: 12, P: 1-7
Recovery of centralities in medial prefrontal and sensory-related cortices associated with social behavior improvements in an autism mouse model

Hiroki Ueno
Yusuke Iyanaga
Atsushi Kasai
ResearchOpen Access02 Jul 2025
Scientific Reports

Volume: 15, P: 1-13
RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach

Taiki Hashimoto
Reiko Ogawa
Shigeki Sekine
Research13 Nov 2018
Modern Pathology

Volume: 32, P: 568-575
Differential potentials of neural progenitors for the generation of neurons and non-neuronal cells in the developing amniote brain

Yuki Hashimoto
Hitoshi Gotoh
Tadashi Nomura
ResearchOpen Access14 Mar 2019
Scientific Reports

Volume: 9, P: 1-9
Antigen-receptor genes of the agnathan lamprey are assembled by a process involving copy choice

Fumikiyo Nagawa
Natsuko Kishishita
Hitoshi Sakano
Research24 Dec 2006
Nature Immunology

Volume: 8, P: 206-213
PACAP suppresses dry eye signs by stimulating tear secretion

Dry eye disease is a complex condition with limited treatments. Here the authors show that mice lacking a multi-functional peptide PACAP develop dry eye-like signs that can be topically treated with PACAP peptide that stimulates tearing in mice, suggesting a possible therapy in humans with dry eyes.

Tomoya Nakamachi
Hirokazu Ohtaki
Seiji Shioda
ResearchOpen Access27 Jun 2016
Nature Communications

Volume: 7, P: 1-13
Influence of hospital capabilities and prehospital time on outcomes of thrombectomy for stroke in Japan from 2013 to 2016

Ai Kurogi
Daisuke Onozuka
Masayuki Yokota
ResearchOpen Access28 Feb 2022
Scientific Reports

Volume: 12, P: 1-17
Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries

Primary open-angle glaucoma (POAG) is highly heritable, yet not well understood from a genetic perspective. Here, the authors perform a meta-analysis of genome-wide association studies in 34,179 POAG cases, identifying 44 previously unreported risk loci and mapping effects across multiple ethnicities.

Puya Gharahkhani
Eric Jorgenson
Janey L. Wiggs
ResearchOpen Access24 Feb 2021
Nature Communications

Volume: 12, P: 1-16
Phase Modification of Acrylate Rubber/Chlorinated Polypropylene Blends by a Hindered Phenol Compound

Chifei Wu
Yoshio Otani
Koh-hei Nitta
Research01 Apr 2001
Polymer Journal

Volume: 33, P: 322-329
RSS1 regulates the cell cycle and maintains meristematic activity under stress conditions in rice

Cell proliferation in plant meristems is often altered during conditions of stress. In this study, the authors identify a plant protein, RSS1, that is regulated in a cell-cycle dependent manner and is required to maintain shoot and root meristems in the presence of abiotic stress.

Daisuke Ogawa
Kiyomi Abe
Shin Takeda
ResearchOpen Access12 Apr 2011
Nature Communications

Volume: 2, P: 1-11
Anti Electrostatic Properties of Various Types of Ethylene Ionomers

Hitoshi Tachino
Hisaaki Hara
Shinichi Yano
Research01 Oct 1994
Polymer Journal

Volume: 26, P: 1170-1178
Epigenetic modulation of Fgf21 in the perinatal mouse liver ameliorates diet-induced obesity in adulthood

FGF21 exerts beneficial metabolic effects on multiple tissues. Here the authors show that the Fgf21 gene is demethylated during the postnatal suckling period, creating an epigenetic memory that determines the responsiveness of the Fgf21 gene to inducers such as PPARα activators or fasting in adulthood.

Xunmei Yuan
Kazutaka Tsujimoto
Yoshihiro Ogawa
ResearchOpen Access12 Feb 2018
Nature Communications

Volume: 9, P: 1-16
Direct control of shoot meristem activity by a cytokinin-activating enzyme

The plant hormone cytokinin is required for the activity of the shoot meristem, which is responsible for all the aerial organs. Fine-tuning of cytokinin activity by a novel cytokinin-activating enzyme is crucial for the control of the meristem activity. The enzyme, encoded by the LOG gene, catalyses the final step of bioactive cytokinin synthesis by its cytokinin-specific phosphoribohydrolase activity.

Takashi Kurakawa
Nanae Ueda
Junko Kyozuka
Research08 Feb 2007
Nature

Volume: 445, P: 652-655
Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

Yanyan Hao
Keiko Sekine
Mikihiko Naito
Research08 Aug 2004
Nature Cell Biology

Volume: 6, P: 849-860
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial

Kazunori Toyoda
Masatoshi Koga
Hiroaki Tanaka
ResearchOpen Access09 Jul 2024
Hypertension Research

Volume: 47, P: 2238-2249
Oral colonization of antimicrobial-resistant bacteria in home health care participants and their association with oral and systemic status

Saki Nishihama
Miki Kawada-Matsuo
Hitoshi Komatsuzawa
ResearchOpen Access17 Feb 2025
Scientific Reports

Volume: 15, P: 1-12
Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls

Hiroki Masuda
Masahiro Mori
Satoshi Kuwabara
ResearchOpen Access03 Aug 2023
Scientific Reports

Volume: 13, P: 1-14
Establishment of a diabetes mellitus type 1 model in the common marmoset

Wenji Yuan
Satsuki Fukuda
Masayuki Shimoda
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-9
(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice

Rei Yokoyama
Yukio Ago
Hitoshi Hashimoto
ResearchOpen Access23 Feb 2024
Molecular Psychiatry

Volume: 29, P: 1406-1416
Hearing impairment and associated morphological changes in pituitary adenylate cyclase activating polypeptide (PACAP)-deficient mice

Daniel Balazs Fulop
Viktoria Humli
Andrea Tamas
ResearchOpen Access10 Oct 2019
Scientific Reports

Volume: 9, P: 1-15
Does surgery improve neurological outcomes in older individuals with cervical spinal cord injury without bone injury? A multicenter study

Satoshi Nori
Kota Watanabe
Satoshi Kato
Research11 Jun 2022
Spinal Cord

Volume: 60, P: 895-902
Multiple alterations in glutamatergic transmission and dopamine D2 receptor splicing in induced pluripotent stem cell-derived neurons from patients with familial schizophrenia

Kana Yamamoto
Toshihiko Kuriu
Takanobu Nakazawa
ResearchOpen Access25 Oct 2021
Translational Psychiatry

Volume: 11, P: 1-8
Psychiatric-disorder-related behavioral phenotypes and cortical hyperactivity in a mouse model of 3q29 deletion syndrome

Masayuki Baba
Kazumasa Yokoyama
Takanobu Nakazawa
ResearchOpen Access19 Jun 2019
Neuropsychopharmacology

Volume: 44, P: 2125-2135
Whole-exome sequencing and neurite outgrowth analysis in autism spectrum disorder

Ryota Hashimoto
Takanobu Nakazawa
Hitoshi Hashimoto
ResearchOpen Access19 Nov 2015
Journal of Human Genetics

Volume: 61, P: 199-206
Can serum periostin predict bronchopulmonary dysplasia in premature infants?

Hayato Go
Junya Ono
Mitsuaki Hosoya
Research27 Dec 2021
Pediatric Research

Volume: 92, P: 1108-1114
Whole-brain block-face serial microscopy tomography at subcellular resolution using FAST

A new protocol for high-speed whole-brain fluorescence imaging using block-face serial microscopy tomography (FAST). The protocol contains procedures for hardware assembly, sample preparation, imaging and data processing.

Kaoru Seiriki
Atsushi Kasai
Hitoshi Hashimoto
Protocols08 Apr 2019
Nature Protocols

Volume: 14, P: 1509-1529

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