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KCTD10 interacts with the DNA replication machinery and the RNA polymerase complex, inducing ubiquitination and removal of the transcription machinery in the event of co-directional transcription–replication conflicts.

Growing use of ionizing radiation in medicine and industry has increased risk of radiation exposure and injury. Here, Deng et al. utilize molecular engineering of melanin to develop a panel of metal-free melanin materials for shielding against γ-ray radiation.

Effective delivery of therapeutic agents to the infection site and the modulation of the immunosuppressive microenvironment at the site of infection are vital for the treatment of chronic bacterial infections but remain elusive. Here, the authors address these issues by developing a nanomedicine that combines chemical and immunological therapies for chronic bacterial infection management.

Sphingosine-1-phosphate receptor 1 (S1PR1) is a drug target for inflammatory bowel disease (IBD), impacting immune cell movement, but current treatments carry immunosuppression risks. Here, the authors show that a Gi-biased S1PR1 agonist, SAR247799, protects the endothelial barrier in IBD models without affecting immune cell egress, offering a potential new treatment strategy.

In this triple-arm, placebo-controlled phase 3 trial, first-line treatment of patients with extensive-stage small-cell lung cancer with the anti-PD-L1 benmelstobart, tyrosine kinase inhibitor anlotinib and chemotherapy (CT) showed improved survival outcomes compared with anlotinib and CT or CT alone.

An alternative approach to physical vapor deposition is demonstrated here for accessing ultrastable metallic glasses via the glass-to-glass transition, a bulk transformation that is inherently free from size constraints and anisotropy.

Cryo-electron microscopy structures reveal the mechanisms underlying multiple-substrate specificity, coupling of epoxidation with carboxylation and allosteric motions during VKGC catalysis, offering potential strategies for targeting haemostatic and non-haemostatic disorders associated with defects in γ-carboxylation.

Matrix stiffening is a feature of pulmonary fibrosis, and is amplified by lung myofibroblasts. Here the authors find that a6 integrin expression is upregulated on lung myofibroblasts in response to matrix stiffness, and this integrin is required for myofibroblast invasion, and fibrosis in an experimental disease model.

Gold-siRNA clusters boost the immune response of radiotherapy against primary and distant tumors.

Micro-supercapacitors are promising energy storage systems to power the future electronic devices. Here, the authors utilize honeycomb alumina nanoscaffold as a nanostructuring platform to design nanoelectrodes and construct micro-supercapacitors with impressive performance.

Single-wall carbon nanotubes have been reported in field effect transistors as a function of nanotube diameter, showing increasing current with increasing diameter. Su et al. show how the chiral structures of single-wall carbon nanotubes affect their electrical transport properties.

Design of artificial catalysts to mimic enzyme activity and selectivity is a challenge in the catalysis field. Here, the authors design a platinum catalyst with a porous cage ligand which shows enzyme-like properties, such as high hydrosilylation activity and substrate size selectivity, while being recyclable.

Large-scale production of single-chirality carbon nanotubes has long been a major challenge. Here, authors report a simple, yet effective, method to increase the yield of gel chromatography separation of single-chirality carbon nanotubes by enabling significantly higher concentrations of raw nanotubes solution.

The kiwifruit is an economically and nutritionally important fruit crop with high vitamin C content. Here, the authors report the draft genome sequence of a heterozygous kiwifruit and through comparative genomic analysis provide valuable insight into kiwifruit evolution.

Monoamines and neurotoxicants share a binding pocket in VMAT1 featuring polar sites for specificity and a wrist-and-fist shape for versatility, and monoamine enrichment in storage vesicles arises from dominant import via favoured lumenal-open transition of VMAT1 and protonation-precluded binding during its cytoplasmic-open transition.

Making environmentally responsive materials often requires the use of multi-material devices. Here, the authors report on the use of electric field patterning of alginate hydrogels to make environmentally responsive actuators and demonstrate a range of applications in response to ionic triggers.

Glioblastoma (GBM) cells are metabolically dependent on exogenous cholesterol uptake and targeting cholesterol metabolism has been proposed as a therapeutic option for GBM. Here the authors show that cholesterol promotes phagocytic dysfunction in tumor associated macrophages and they develop an Apo-A1 armed oncolytic adenovirus restoring anti-tumor immunity in GBM preclinical models.

Thermoelectric modules can generate electricity directly from heat and have applications to waste heat-energy conversion. Here Zhouet al. have fabricated a thermoelectric module based on an air-stable n-type single-walled carbon nanotube sheet which can reach a high power factor of 1500 μWm⁻¹K⁻².

Modifiers of diverse materials exhibit structures or compositions that differ from a solute molecule but often contain similar functional motifs that facilitate molecular recognition for modifier binding to crystal surfaces. Here the authors examine the intrinsic capability of tautomers, or structural isomers, to operate as crystal growth inhibitors.’

Clamping effects in ferroelestastic thin films limits their usefulness for applications such as sensitive mechanical sensors. Here, the authors report on non-local mechanical force induced switching in PbTiO₃ thin films by tuning the material to a state of nearly energetically degenerate co-existing domains.

The underlying mechanism of amyloid β (Aβ) oligomer-induced aberrant neurotransmitter release remains unclear. Here, authors show that the release probability at the synapse between the Schaffer collateral and CA1 pyramidal neurons is significantly reduced at an early stage in mouse models of AD with elevated Aβ production and is mainly due to an mGluR5-mediated depletion of PIP2 in axons.

A cyclic block copolymer allows feasible fabrication of porous films through designed interaction between its macromolecular arms. The morphology of pores is directly determined by the structural features of the block copolymer and can be easily tuned by modification of the length of its ring and arms.