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Showing 1–8 of 8 results
Advanced filters: Author: Huating Gu Clear advanced filters

  • In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

    • Jiaming Li
    • Mengmeng Jiang
    • Guang-Hui Liu
    Reviews
    Nature Aging
    Volume: 5, P: 1669-1685

  • Neural circuit mechanisms that regulate the panic-like defensive state are not fully understood. Using a robot-based experimental paradigm, the authors identify Cbln2-expressing (Cbln2+) neurons in the mouse posterior hypothalamic nucleus (PHN) as a key neuronal population essential for the induction of panic-like defensive state.

    • Miao Zhao
    • Li Zhang
    • Peng Cao
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Tailored to provide diabetes management recommendations from large training and validation datasets, an artificial intelligence system integrating language and computer vision capabilities is shown to improve self-management of patients in a prospective implementation study.

    • Jiajia Li
    • Zhouyu Guan
    • Tien Yin Wong
    ResearchOpen Access
    Nature Medicine
    Volume: 30, P: 2886-2896

  • Goal-oriented movement is a fundamental animal behaviour. Here, the authors show that neurons in the superior colliculus project to the substantia nigra pars compacta, regulating dopaminergic signaling and specifically appetitive locomotion in mice.

    • Meizhu Huang
    • Dapeng Li
    • Peng Cao
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17

  • The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function through chromatin remodeling and activation of gene expression.

    • Jennifer M. Peterson
    • David J. Wang
    • Denis C. Guttridge
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • The use of biomarkers of ageing is crucial for investigating age-related processes. This Review discusses biomarkers of ageing and of ageing-associated physiological changes, at the cellular, tissue and organism levels in humans and non-human primates.

    • Zeming Wu
    • Jing Qu
    • Guang-Hui Liu
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 26, P: 826-847