Acute kidney injury (AKI) frequently arises as a complication of hepatic ischemia reperfusion injury (HIRI), yet simultaneous optical imaging of both remains challenging. Here, the authors develop a unimolecular cascaded activatable reporter with dual responses and pharmacokinetic conversion for non-invasive multiplex chemiluminescence imaging and fluorescent urinalysis of HIRI and associated AKI.
- Bankang Ruan
- Weiliang Deng
- Jiaguo Huang
