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Acta Pharmacologica Sinica (21)
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Showing 1–50 of 76 results

Advanced filters: Author: Hui-Min Zhang Clear advanced filters

Determination of the inhibitory potential of 6 fluoroquinolones on CYP1A2 and CYP2C9 in human liver microsomes

Li Zhang
Min-ji Wei
Hui-min Qi
Research01 Dec 2008
Acta Pharmacologica Sinica

Volume: 29, P: 1507-1514
A phase III clinical trial of monthly minodronate in the treatment of Chinese postmenopausal women with osteoporosis

Hao Zhang
Ya-nan Huo
Zhen-lin Zhang
Research01 Oct 2025
Acta Pharmacologica Sinica

P: 1-8
The oncological safety in minimally invasive versus open distal pancreatectomy for pancreatic ductal adenocarcinoma: a systematic review and meta-analysis

Du-Jiang Yang
Jun-Jie Xiong
Wei-Ming Hu
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-8
Hyperactivity of subicular parvalbumin interneurons drives early amyloid pathology and cognitive deficits in Alzheimer’s disease

Yan-Bing Chen
Bo Jiang
Jie Zhang
ResearchOpen Access06 Sept 2025
Molecular Psychiatry

P: 1-13
Space weathering on the lunar nearside and farside constrained from Si isotopes

Chang’E-5 and Chang’E-6 lunar soils show higher δ30Si than lunar basalts, with CE-6 having the highest value, suggesting space weathering produced by micrometeorite impacts alters Si isotopes of lunar soils, with stronger effects on the farside.

Hui-Yan Zhang
Hui-Min Yu
Fang Huang
ResearchOpen Access07 May 2025
Nature Communications

Volume: 16, P: 1-7
Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Gut microbiota has been reported to influence osteoporosis risk, but the individual species, and underlying mechanisms, remain largely unknown. Here, the authors identify Bacteroides vulgatus and serum valeric acid as potential targets for osteoporosis prevention/treatment.

Xu Lin
Hong-Mei Xiao
Hong-Wen Deng
ResearchOpen Access27 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Pseudo-adsorption and long-range redox coupling during oxygen reduction reaction on single atom electrocatalyst

The reaction region is commonly considered to be the direct catalyst surface. Here, the authors challenge this view and use molecular dynamics simulations to reveal a solvated hydroxide species dynamically confined in a pseudo-adsorption state at a few water layers away from the active site during oxygen reduction reaction on single atom electrocatalyst.

Jie-Wei Chen
Zisheng Zhang
Yang-Gang Wang
ResearchOpen Access01 Apr 2022
Nature Communications

Volume: 13, P: 1-13
GDF11 slows excitatory neuronal senescence and brain ageing by repressing p21

How excitatory neurons (EN) acquire senescence is unclear. Here, the authors show that GDF11 in ENs slows EN senescence, brain ageing, cognitive decline and maintains lifespan, revealing a mechanism underlying EN senescence and brain ageing.

Di-Xian Wang
Zhao-Jun Dong
Jing-Wei Zhao
ResearchOpen Access17 Nov 2023
Nature Communications

Volume: 14, P: 1-24
Restoring nuclear entry of Sirtuin 2 in oligodendrocyte progenitor cells promotes remyelination during ageing

Age-dependent decline in remyelination in the CNS is associated with declined differentiation capacity of oligodendrocyte progenitor cells (OPCs). Here, the authors show nuclear entry of SIRT2 is impaired and NAD+ levels are reduced during ageing in mouse OPCs. β-nicotinamide mononucleotide (β-NMN) supplement delays myelin aging and enhances remyelination in the aged mice.

Xiao-Ru Ma
Xudong Zhu
Jing-Wei Zhao
ResearchOpen Access09 Mar 2022
Nature Communications

Volume: 13, P: 1-19
Interleukin-17A is involved in development of spontaneous pulmonary emphysema caused by Toll-like receptor 4 mutation

Qing-qing Wang
Hong-zhen Yang
Zhuo-wei Hu
Research27 Jun 2011
Acta Pharmacologica Sinica

Volume: 32, P: 1045-1054
Genetically driven adiposity traits increase the risk of coronary artery disease independent of blood pressure, dyslipidaemia, glycaemic traits

Wan-Qiang Lv
Xue Zhang
Hong-Wen Deng
Research11 Jun 2018
European Journal of Human Genetics

Volume: 26, P: 1547-1553
Stereoselective hydrogen atom transfer to acyclic radicals: a switch enabling diastereodivergent borylative radical cascades

Stereochemical control of acyclic carbon radical intermediates remains a challenge, due to the difficulty in differentiation between the two faces of the planar species. Here the authors show diastereodivergent hydrogen atom transfer to acyclic carbon radicals via control of N-heterocyclic carbene–borane reagents with either a thiol catalyst or a Lewis acid.

Tian Ye
Feng-Lian Zhang
Yi-Feng Wang
ResearchOpen Access20 Jan 2022
Nature Communications

Volume: 13, P: 1-12
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer

Statins have anti-cancer effects that are modulated by the gut commensal Lactobacillus reuteri and the tryptophan metabolite, indole-3-lactic acid, in mice and humans.

Ji-Xuan Han
Zhi-Hang Tao
Jing-Yuan Fang
Research17 Apr 2023
Nature Microbiology

Volume: 8, P: 919-933
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development

Seryl-tRNA synthetase is important in vasculogenesis and contains a unique domain at its C-terminus. In this study, the unique domain is shown to target the protein to the nucleus, block expression ofvegfaand be essential for vasculogenesis in zebrafish.

Xiaoling Xu
Yi Shi
Xiang-Lei Yang
ResearchOpen Access21 Feb 2012
Nature Communications

Volume: 3, P: 1-9
Nucleotide-induced conformational changes of tetradecameric GroEL mapped by H/D exchange monitored by FT-ICR mass spectrometry

Qian Zhang
Jin Chen
Alan G. Marshall
ResearchOpen Access13 Feb 2013
Scientific Reports

Volume: 3, P: 1-7
Assembly of coupled redox fuel cells using copper as electron acceptors to generate power and its in-situ retrieval

Hui-Min Zhang
Wei Xu
Bo-Geng Li
ResearchOpen Access15 Feb 2016
Scientific Reports

Volume: 6, P: 1-8
Role of Dnl4–Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination

Yu Zhang
Melissa L Hefferin
Alan E Tomkinson
Research24 Jun 2007
Nature Structural & Molecular Biology

Volume: 14, P: 639-646
Long-term blood pressure outcomes of patients with adrenal venous sampling-proven unilateral primary aldosteronism

Xu Meng
Wen-Jun Ma
Ying Lou
Research05 Sept 2019
Journal of Human Hypertension

Volume: 34, P: 440-447
Non-canonical reader modules of BAZ1A promote recovery from DNA damage

ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and bromodomain modules of the paralog BAZ1A.

Mariano Oppikofer
Meredith Sagolla
Andrea G. Cochran
ResearchOpen Access11 Oct 2017
Nature Communications

Volume: 8, P: 1-15
Expanding agroforestry can increase nitrate retention and mitigate the global impact of a leaky nitrogen cycle in croplands

The spatial patterns of global soil potential nitrogen cycling were characterized using 4,032 observations from 398 published studies. The global soil nitrogen cycle shifts from conservative in forests to leaky in croplands, highlighting the importance of forests in the global nitrogen cycle and the need for further insights on nitrate retention in croplands.

Ahmed S. Elrys
Yves Uwiragiye
Christoph Müller
ResearchOpen Access28 Dec 2022
Nature Food

Volume: 4, P: 109-121
Activation of Toll-like receptor 9 attenuates unilateral ureteral obstruction-induced renal fibrosis

Bing-mu Xin
Xiao-xing Wang
Zhuo-wei Hu
Research29 Nov 2010
Acta Pharmacologica Sinica

Volume: 31, P: 1583-1592
The pro-inflammatory signalling regulator Stat4 promotes vasculogenesis of great vessels derived from endothelial precursors

Stat4 is a transcription factor known to regulate pro-inflammatory signalling. Here, Menget al. show that Stat4 is not only regulating inflammation but it is also crucial for great vessels development and endothelial precursor proliferation in zebrafish, by inhibiting the expression of hdac3and counteracting the effect of Stat1a.

Zhao-Zheng Meng
Wei Liu
Yong Zhou
ResearchOpen Access03 Mar 2017
Nature Communications

Volume: 8, P: 1-12
Detecting epistasis within chromatin regulatory circuitry reveals CAND2 as a novel susceptibility gene for obesity

Shan-Shan Dong
Shi Yao
Tie-Lin Yang
Research01 May 2018
International Journal of Obesity

Volume: 43, P: 450-456
High Oscillospira abundance indicates constipation and low BMI in the Guangdong Gut Microbiome Project

Yi-ran Chen
Hui-min Zheng
Zhi-cong Yang
ResearchOpen Access09 Jun 2020
Scientific Reports

Volume: 10, P: 1-8
Heterogeneity of cannabinoid ligand-induced modulations in intracellular Ca²⁺ signals of mouse pancreatic acinar cells in vitro

Kun-kun Xia
Jian-xin Shen
Jie Wu
Research10 Sept 2018
Acta Pharmacologica Sinica

Volume: 40, P: 410-417
BRD1 deficiency affects SREBF1-related lipid metabolism through regulating H3K9ac/H3K9me3 transition to inhibit HCC progression

Mingyang Zhang
Jing Bai
Changshan Wang
ResearchOpen Access17 Feb 2025
Cell Death & Disease

Volume: 16, P: 1-14
STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer

Jun Wang
Hui-min Zhang
Yuan Xiang
Research12 Dec 2024
Acta Pharmacologica Sinica

Volume: 46, P: 1097-1110
Transcutaneous auricular vagus nerve stimulation improves cortical functional topological properties and intracortical facilitation in patients with Parkinson’s disease

Heng Zhang
Ai-di Shan
Ke-zhong Zhang
ResearchOpen Access01 Mar 2025
npj Parkinson's Disease

Volume: 11, P: 1-10
The cryptic lncRNA-encoded microprotein TPM3P9 drives oncogenic RNA splicing and tumorigenesis

Kun Meng
Yuying Li
Chris Zhiyi Zhang
ResearchOpen Access27 Jan 2025
Signal Transduction and Targeted Therapy

Volume: 10, P: 1-17
Siblicide between fertilized and unfertilized ovaries within the maize ear

Grains suppress ovaries in ears of maize to strengthen their sugar utilization advantage for development, potentially through hormone and MAPK signaling.

Cheng Huang
Zhi-Wei Wang
Shun-Li Zhou
ResearchOpen Access31 Mar 2025
Communications Biology

Volume: 8, P: 1-13
Pretreatment with a combination of ligustrazine and berberine improves cardiac function in rats with coronary microembolization

Ying Zhang
Xiao-juan Ma
Da-zhuo Shi
Research29 Feb 2016
Acta Pharmacologica Sinica

Volume: 37, P: 463-472
RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells

Tao Yang
Cai-gui Xiang
Wei Tang
ResearchOpen Access23 Mar 2024
Cell Death Discovery

Volume: 10, P: 1-12
The Study of Aortic Stiffness in Different Hypertension Subtypes in Dialysis Patients

Li-Tao Cheng
Hui-Min Chen
Tao Wang
Research01 Apr 2008
Hypertension Research

Volume: 31, P: 593-599
MKL-1-induced PINK1-AS overexpression contributes to the malignant progression of hepatocellular carcinoma via ALDOA-mediated glycolysis

Jun Wang
Hui-Min Zhang
Xing-Hua Liao
ResearchOpen Access09 Dec 2022
Scientific Reports

Volume: 12, P: 1-13
Exosomal microRNA-15a from mesenchymal stem cells impedes hepatocellular carcinoma progression via downregulation of SALL4

Yu-Shui Ma
Ji-Bin Liu
Da Fu
ResearchOpen Access28 Aug 2021
Cell Death Discovery

Volume: 7, P: 1-11
Administration of A. muciniphila ameliorates pulmonary arterial hypertension by targeting miR-208a-3p/NOVA1 axis

Zheng-yi Bao
Hui-min Li
Lan-juan Li
Research11 Jul 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2201-2215
Satellite cell-derived exosome-mediated delivery of microRNA-23a/27a/26a cluster ameliorates the renal tubulointerstitial fibrosis in mouse diabetic nephropathy

Jia-ling Ji
Hui-min Shi
Ai-qing Zhang
Research18 Aug 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2455-2468
Oncoprotein LAMTOR5-mediated CHOP silence via DNA hypermethylation and miR-182/miR-769 in promotion of liver cancer growth

Xue Wang
Qian-qian Li
Li-hong Ye
Research28 Jun 2024
Acta Pharmacologica Sinica

Volume: 45, P: 2625-2645
Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage

Chemotherapeutics treatment led to the Ca²⁺ overload and MAPKs activation, resulting in DNA damage and cell death ultimately in both HCC cells and hepatic cells. Meanwhile, the expression of mGlu₅ in HCC cells was downregulated in response to chemotherapeutics, and inhibition of mGlu₅ aggravated the cytotoxicity of chemotherapeutics but the agonist of mGlu₅ reversed this effect. Unlike HCC cells, chemotherapeutics upregulated the expression of mGlu₅ in hepatic cells, and the inhibition of mGlu₅ resisted the hepatotoxicity.

Hui-Min Yang
Tian-Zhong Hou
Hong Zhang
Research08 Apr 2022
Cancer Gene Therapy

Volume: 29, P: 1487-1501
Author Correction: NRF2-GPX4/SOD2 axis imparts resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer cells

Chun-shuang Ma
Qian-ming Lv
Liang Zhu
Amendments and Corrections01 Aug 2023
Acta Pharmacologica Sinica

Volume: 44, P: 2346
Identification of an allatostatin C signaling system in mollusc Aplysia

Hui-Min Jiang
Zhe Yang
Jian Jing
ResearchOpen Access24 Jan 2022
Scientific Reports

Volume: 12, P: 1-13
Kanglexin delays heart aging by promoting mitophagy

Hui-min Li
Xin Liu
Bao-feng Yang
Research25 May 2021
Acta Pharmacologica Sinica

Volume: 43, P: 613-623
Association between serum homocysteine and erectile dysfunction: a systematic review and meta-analysis

Peng Cheng
Hui-min Li
Xiao-lei Tang
Reviews30 Nov 2024
International Journal of Impotence Research

Volume: 37, P: 574-582
Macrophage migration inhibitory factor (MIF) acetylation protects neurons from ischemic injury

Jin-Xia Hu
Wei-Jing Ma
Lei Li
ResearchOpen Access18 May 2022
Cell Death & Disease

Volume: 13, P: 1-13
Methionine-choline deficient diet deteriorates DSS-induced murine colitis through disturbance of gut microbes and infiltration of macrophages

Mo-ting Liu
Yao Zhang
Wei Tang
Research29 Apr 2024
Acta Pharmacologica Sinica

Volume: 45, P: 1912-1925
Comprehensive functional annotation of susceptibility SNPs prioritized 10 genes for schizophrenia

Hui-Min Niu
Ping Yang
Yan Guo
ResearchOpen Access31 Jan 2019
Translational Psychiatry

Volume: 9, P: 1-12
HOXD10 attenuates renal fibrosis by inhibiting NOX4-induced ferroptosis

Xin Li
Tian-Kui Ma
Hong Ding
ResearchOpen Access06 Jun 2024
Cell Death & Disease

Volume: 15, P: 1-14
GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma

Ning-xiang Shen
Ming-yu Luo
Ying Shen
Research05 Jul 2024
Oncogene

Volume: 43, P: 2504-2516
Sorafenib triggers ferroptosis via inhibition of HBXIP/SCD axis in hepatocellular carcinoma

Lu Zhang
Xian-meng Li
Li-hong Ye
Research15 Sept 2022
Acta Pharmacologica Sinica

Volume: 44, P: 622-634
EPHA2 mediates PDGFA activity and functions together with PDGFRA as prognostic marker and therapeutic target in glioblastoma

Qu-Jing Gai
Zhen Fu
Yan Wang
ResearchOpen Access02 Feb 2022
Signal Transduction and Targeted Therapy

Volume: 7, P: 1-12

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