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Showing 1–10 of 10 results
Advanced filters: Author: Hyung Joon Shim Clear advanced filters

  • Chimeric antigen receptor (CAR)-T cell is a promising therapy for hematological malignancy, but further optimization is still desirable. Here the authors show that incorporating CD99, a membrane protein expressed on activated T cells, transmembrane and juxtamembrane domains into CAR design helps improve CAR-T efficacy in vitro and in vivo in mice.

    • Giri Nam
    • Hye Ran Yeon
    • Eun Young Choi
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • Understanding how the immune system’s functionality declines with age is crucial for addressing aging-related health issues. Here, the authors demonstrate that activating TLR5 in the mucosal layer can significantly improve healthspan and longevity, suggesting a novel approach for aging interventions.

    • Jae Sung Lim
    • Eun Jae Jeon
    • Kyung A Cho
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-14

  • An integrated electronic platform with site-specific sensitivity is highly needed for medical applications. Here, Kim et al.report a stretchable prosthetic skin composed of ultrathin single crystalline silicon nanoribbon array, which can sense strain, pressure and temperature spontaneously.

    • Jaemin Kim
    • Mincheol Lee
    • Dae-Hyeong Kim
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Protonic ceramic fuel cells are promising for energy applications, but maintaining high performance with long-term stability is an issue. Here the authors use a stable yttrium-doped barium zirconate electrolyte, achieving a power output one order of magnitude higher than existing protonic ceramic fuel cells.

    • Kiho Bae
    • Dong Young Jang
    • Joon Hyung Shim
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Protonic ceramic fuel cells (PCFCs) are a potential alternative to solid oxide fuel cells at temperatures below 600 °C, but they suffer from low power output and poor chemical stability. Now, PCFCs with a power density of over 500 mW per cm2 at 500 °C and long-term stability are demonstrated using optimized perovskite-based electrolyte and electrodes.

    • Joon Hyung Shim
    News & Views
    Nature Energy
    Volume: 3, P: 168-169

  • Kim et al. conducted single-cell RNA sequencing to determine the transcriptome profiles of human nail units using polydactyly specimens to demonstrate mesenchymal and epithelial cell populations, characterized by RSPO4 and SPINK6 respectively. RSPO4 + onychofibroblasts localized with LGR6 + nail matrix, leading to WNT/ β-catenin activation and suggesting a role for onychofibroblasts in onychomatricoma pathogenesis.

    • Hyun Je Kim
    • Joon Ho Shim
    • Dongyoun Lee
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13