Nature Search

The endophilin–CIN85–Cbl complex mediates ligand-dependent downregulation of c-Met

Annalisa Petrelli
Giorgio F. Gilestro
Silvia Giordano
Research14 Mar 2002
Nature

Volume: 416, P: 187-190
Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signalling mode

Receptor tyrosine kinases can be auto-activated independent of ligand. Sabet et al.show that on ligand stimulation, ephrin receptor EphA2 switches from auto-activation suppression by vesicular recycling to ligand-dependent signalling limited by directional trafficking to late endosomes/lysosomes.

Ola Sabet
Rabea Stockert
Philippe I. H. Bastiaens
ResearchOpen Access21 Aug 2015
Nature Communications

Volume: 6, P: 1-13
Cbl escapes Cdc42-mediated inhibition by downregulation of the adaptor molecule βPix

M H H Schmidt
K Husnjak
I Dikic
Research16 Jan 2006
Oncogene

Volume: 25, P: 3071-3078
Heteromeric clusters of ubiquitinated ER-shaping proteins drive ER-phagy

The membrane-shaping protein ARL6IP1 is involved in the selective degradation of the endoplasmic reticulum, and this process depends on its ubiquitination and interaction with other membrane-shaping proteins such as FAM134B.

Hector Foronda
Yangxue Fu
Christian A. Hübner
ResearchOpen Access24 May 2023
Nature

Volume: 618, P: 402-410
Regulation of endoplasmic reticulum turnover by selective autophagy

The protein FAM134B is an endoplasmic reticulum (ER)-resident receptor that facilitates ER autophagy, and downregulation of this protein (mutations of which are also known to cause sensory neuropathy in humans) results in expanded ER structures and degeneration of mouse sensory neurons.

Aliaksandr Khaminets
Theresa Heinrich
Ivan Dikic
Research03 Jun 2015
Nature

Volume: 522, P: 354-358
Linear ubiquitination prevents inflammation and regulates immune signalling

Björn Gerlach
Stefanie M. Cordier
Henning Walczak
Research30 Mar 2011
Nature

Volume: 471, P: 591-596
Generation of lightning in Jupiter's water cloud

S. Gibbard
E. H. Levy
J. I. Lunine
Research07 Dec 1995
Nature

Volume: 378, P: 592-595
Macrophages downregulate NEDD9 to counteract S. Typhimurium- mediated FAK-AKT activation and lysosome inhibition

Julia Fischer
Lisa Rusyn
Tamina Seeger-Nukpezah
ResearchOpen Access12 Jun 2025
Cell Death & Disease

Volume: 16, P: 1-13
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

Ubiquitin and ubiquitin-like proteins (Ubls) participate in many cellular processes, such as apoptosis and DNA repair. How can the deregulation of ubiquitin and Ubls lead to cancer formation, and how might ubiquitin and Ubl pathways be targeted by anticancer therapeutics?

Daniela Hoeller
Christina-Maria Hecker
Ivan Dikic
Reviews01 Oct 2006
Nature Reviews Cancer

Volume: 6, P: 776-788
Ubiquitination regulates ER-phagy and remodelling of endoplasmic reticulum

Ubiquitination of the receptor FAM134B regulates ER-phagy and remodelling of the endoplasmic reticulum in response to cellular demands.

Alexis González
Adriana Covarrubias-Pinto
Ivan Dikić
ResearchOpen Access24 May 2023
Nature

Volume: 618, P: 394-401
Essential role of accessory subunit LYRM6 in the mechanism of mitochondrial complex I

Respiratory complex I plays a key role in energy metabolism. Cryo-EM structure of a mutant accessory subunit LYRM6 from the yeast Yarrowia lipolytica and molecular dynamics simulations reveal conformational changes at the interface between LYRM6 and subunit ND3, propagated further into the complex. These findings offer insight into the mechanism of proton pumping by respiratory complex I.

Etienne Galemou Yoga
Kristian Parey
Heike Angerer
ResearchOpen Access26 Nov 2020
Nature Communications

Volume: 11, P: 1-8
Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

S Wagner
I Carpentier
R Beyaert
Research21 Jan 2008
Oncogene

Volume: 27, P: 3739-3745
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Michaela Reissland
Oliver Hartmann
Markus E. Diefenbacher
ResearchOpen Access23 Oct 2024
Oncogene

Volume: 43, P: 3645-3659
Restriction factor compendium for influenza A virus reveals a mechanism for evasion of autophagy

Multi-omics analysis of influenza A virus cellular restriction in human macrophage-like cells reveals a mechanism for viral evasion of autophagy.

Laura Martin-Sancho
Shashank Tripathi
Sumit K. Chanda
Research23 Sept 2021
Nature Microbiology

Volume: 6, P: 1319-1333
PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

D Mazzà
P Infante
L Di Marcotullio
Research06 Sept 2013
Cell Death & Differentiation

Volume: 20, P: 1688-1697
Tumor suppressor Pdcd4 inhibits invasion/intravasation and regulates urokinase receptor (u-PAR) gene expression via Sp-transcription factors

J H Leupold
H-S Yang
H Allgayer
Research12 Feb 2007
Oncogene

Volume: 26, P: 4550-4562
Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling

Kirsty E Ratcliffe
Qi Tao
Bruce I Terman
Research12 Sept 2002
Oncogene

Volume: 21, P: 6307-6316
Correction: USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer

Michaela Reissland
Oliver Hartmann
Markus E. Diefenbacher
Amendments and CorrectionsOpen Access22 Jan 2025
Oncogene

Volume: 44, P: 336
Ubiquitination and selective autophagy

S Shaid
C H Brandts
I Dikic
Reviews22 Jun 2012
Cell Death & Differentiation

Volume: 20, P: 21-30
Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

F Pareja
D A Ferraro
Y Yarden
Research19 Dec 2011
Oncogene

Volume: 31, P: 4599-4608

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