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By combining satellite observations with ground-based data and expert validation, this analysis demonstrates considerable misestimation of grassland extent and thereby carbon stock estimates in previous global assessments based on remote sensing.

The famous nebula Barnard 68 has been used as a giant cosmic-ray detector: cosmic-ray-excited vibrational H₂ emission has been observed by JWST, giving a direct measurement of the CR ionization rate.

Saturation genome editing of a cancer mutation hotspot in CTNNB1, the gene encoding β-catenin, reveals a gradient of effects of missense mutations on Wnt signaling.

2D polymer materials are often limited in performance by insufficient in-plane conjugation and poor charge transport. Guided by theoretical calculations, the authors present diketopyrrolopyrrole-based crystalline 2D poly(arylene vinylene)s with narrow optical band gaps of 1 eV and high charge carrier mobility.

A modular, point-of-care device combining hemispheric plasmonic nanoarrays and automated microfluidics enables nucleic acid amplification and metabolic cell viability assay for rapid bacterial identification and antibiotic susceptibility testing.

This study uses single-nucleus RNA sequencing to analyze lung tissue from 141 individuals with chronic obstructive pulmonary disease. Distinct patterns of spatially resolved changes in cell composition and cell states that correlate with clinical features are highlighted.

The study presents a recyclable polymer system that stores solar energy and releases it as hydrogen on demand, offering an efficient and sustainable route for renewable energy storage and fuel generation.

Ribas and colleagues report the results of a phase 2 clinical trial of neoadjuvant PD-1 blockade in patients with surgically resectable desmoplastic melanoma.

Generating high-quality training data for machine learning is costly. Here, authors include sequence-to-function modeling in benchmarking of custom and commercial droplet-based scATAC platforms, and release a new Drosophila embryo atlas along with a new mouse cortex atlas, assessed for model interpretability.

This study examines long-term changes in species richness across tropical forests in the Andes and Amazon. Hotter, drier and more seasonal forests in the eastern and southern Amazon are losing species, while Northern Andean forests are accumulating species, acting as a refuge for climate-displaced species.

Sepsis causes endothelial dysfunction that drives vascular failure and organ injury. Here the authors show that neutralizing truncated procalcitonin reduced pro-inflammatory activation and leakage in the endothelium, resulting in preserved organ integrity, improved clinical outcomes and predicted survival in septic mice.

Coherent spin waves—quantized into magnons—can be emitted as Cherenkov radiation, but their experimental realization is hindered by the lack of fast-moving magnetic perturbations. Now, a picosecond strain pulse is shown to induce this effect.

This study surveyed key informants across 26 countries on burning plastic for waste management and energy needs. It finds high awareness of this practice, with potential drivers including inadequate waste collection and a lack of affordable fuels.

Identifying jets originating from heavy quarks plays a fundamental role in hadronic collider experiments. In this work, the ATLAS Collaboration describes and tests a transformer-based neural network architecture for jet flavour tagging based on low-level input and physics-inspired constraints.

3-Hydroxypropionic acid (3HP) is a top Department of Energy value-added chemical and precursor to bioplastics, yet cost-effective microbial bioproduction remains elusive. Here the authors establish efficient 3HP production in an acid tolerant yeast and validate its financially viability.

An alternative mating system, termed parasex, produces progeny with high levels of genotypic diversity and is able to fulfil the roles of meiosis when it is absent in the fungal pathobiont Candida albicans.

Guided by density functional theory, a commercially viable refractory alloy is developed, which exhibits excellent room-temperature ductility and strength, and high strength at elevated temperatures.

A multiancestry phenome-wide analysis of copy number variants in the UK Biobank genomes increases power to detect genetic associations with complex traits across human populations.

Transcription factor osr2 is identified as a specific marker and regulator of mural lymphatic endothelial cell (muLEC) differentiation and maintenance, and muLECs and border-associated macrophages share functional analogies but are not homologous, providing an example of convergent evolution.

The structure and functioning of soil food webs between biomes remains unknown. Here, tropical soil food webs are shown to have higher energy flux, predation and herbivory than temperate soil food webs which are based on litter and microbial biomass.

This study estimates construction-related emissions and carbon budgets for over 1,000 cities worldwide. Through quantitative analysis and an accessible open dashboard, this study empowers city stakeholders to craft science-based strategies for aligning future construction growth with climate goals.

The mechanical properties of inorganic solid electrolytes for Li batteries are typically characterised by a high Young’s modulus above 15 GPa and hardness above 1 GPa. Here, authors develop a cost-effective and mechanically compliant inorganic solid electrolyte, with reduced Young’s modulus and hardness of 1.41 and 0.22 GPa, respectively, for practical all-solid-state Li batteries.

Rare cells are often biologically and clinically important, but their low abundance makes them challenging to study using single-cell transcriptomics. Here, the authors develop PURE-seq which integrates FACS and PIP-seq to directly sequence ultra-rare cells. It captures cells at 1 in 1,000,000 rarity, which the authors demonstrate by profiling circulating tumor cells and identifying Egr1 as a regulator of mouse hematopoietic stem cell aging.

Denz et al. show that loss of the antiviral protein IFITM3 allows human SARS-CoV-2 variants to adapt more rapidly in mice while preserving distinct, variant-specific patterns of infection and disease.

A wide survey of pesticide effects on soil biodiversity across 373 sites in Europe reveals that pesticide residues occur in 70% of sites and have major effects on soil biodiversity and functional ecology.

Graft rejection is traditionally attributed to adaptive immune cells that recognize donor-specific alloantigens, with innate immunity having a secondary role. The finding that recipient natural killer cells are activated by the inability of graft endothelial cells to provide HLA-I-mediated inhibitory signals challenges this dogma and introduces the concept of innate rejection.

Tree buds integrate cold and warm cues to control dormancy release. Extended warm periods block plasmodesmata opening by repressing Flowering Locus T and GA pathways in buds. This mechanism ensures robust temporal regulation of dormancy release.

Vassy, Dornisch and colleagues developed a genomics-based prostate cancer risk model to support a randomized clinical trial of precision screening in a national healthcare system.

Despite extensive structural studies elucidating how antigens are anchored to antigen-presenting molecules and presented to T cells, little is known about the display mechanism of the lipid-antigen-presenting molecule CD1c. Here, by combining structural immunology, lipidomics, and biophysical analysis, the authors reveal that the CD1c binding cleft accommodates two different lipids, one of them with a bulky headgroup positioned sideways for display to T cells, rather than upwards, different from the conventional upright antigen-presentation mode

This Review discusses current research and future directions in protein persulfidation and polysulfidation to enable their full potential in redox-based therapeutic efforts.

This Review surveys how higher-order interactions, which link more than two units at a time, reshape collective dynamics in complex systems. New synchronization phenomena, analytical frameworks and emerging methods to reduce or infer higher-order structure from data, are highlighted.

Tropical cyclones cool the ocean surface less than previously thought, indicating that current projections may underestimate their future intensity and frequency, according to an analysis of global sea surface drifters data over 1992–2021.

This Analysis illustrates how nature-positive targets aimed at protecting biodiversity can be achieved at the scale of organizations. A canteen at one UK university college is used as a case study for the application of a four-step participatory approach comprising an estimation of food-related biodiversity impacts; definition of biodiversity targets; assessment of possible interventions; and exploration of different strategies.

Recent advances in the synthesis of graphene fragments that possess unpaired π-electrons and display high-spin ground states have unlocked possibilities to explore exotic physical phenomena related to magnetism. Here, the authors demonstrate the magnetic bistability of a diradical nanographene that allows direct spin manipulation at the single-molecule level.

How landscapes are arranged affects soil pathogenic fungi worldwide. The authors reveal the global pattern and pronounced scale-dependency of landscape complexity and land-cover quantity on soil pathogenic fungal diversity.

This study identifies key neurocognitive domains that distinguish patients with schizophrenia from healthy individuals using machine learning. Analyzing data from 1,304 participants, it demonstrates that verbal learning and emotion identification effectively classify conditions, promoting efficient neurocognitive profiling strategies.

Eight decades of forest plot monitoring show a pervasive increase in tree mortality across Australia’s forest biomes driven by climate change, jeopardizing their role as enduring carbon sinks.

Including data from 1,047 patients across 19 inflammatory diseases, a new atlas presents a comprehensive model of inflammation in circulating immune cells.

Coherently projecting a quantum state may allow it to be probed from a distance. This is now demonstrated for a Yu–Shiba–Rusinov state using a quantum corral.

Nonreciprocal photonics often relies on the use of external magnetic fields. By combining atomistic simulations based on tight-binding with a mean-field approach, here, the authors demonstrate nonreciprocal plasmon propagation in electrically biased one-dimensional carbon nanostructures, including graphene nanoribbons and carbon nanotubes.

CELSR1 is a core component of the tissue/planar cell polarity pathway. Here, the authors report a CELSR1-related disorder featuring brain malformations, neurodevelopmental delay and epilepsy, and use mice to explore the pathophysiological mechanisms.

A histone ubiquitin-dependent regulatory hub governs stimulus-dependent heterochromatin propagation, with important implications for understanding mechanisms governing rapid changes in the epigenetic landscape in physiology and disease.

Chan and colleagues report that tumor ecosystem and microbiome features are associated with response to anti-PD-L1 avelumab plus chemoradiotherapy in patients with locally advanced head and neck cancer.

Despite the potential of free electrons for quantum technological applications, these are still limited by the weak electron-photon interactions. To address this challenge, the authors introduce electron-light couplers that produce high-photon-number state generation, enabling quantum sensing and metrology with unprecedented precision.