Nature Search

Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers

Circulating metabolites reflect complex disease risk and are shaped by diverse genetic factors. Here, the authors show widespread pleiotropy across 249 metabolic traits, identify rare variant and sex-specific effects, and implicate lipid-related pathways in metabolism.

Dennis van der Meer
Zillur Rahman
Ole A. Andreassen
ResearchOpen Access28 May 2025
Nature Communications

Volume: 16, P: 1-12
Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Using normative modeling and focusing on individual differences, the authors explore the link between copy number variations, brain structure and cognitive abilities.

Charlotte Fraza
Ida E. Sønderby
Andre F. Marquand
Research01 Nov 2024
Nature Mental Health

Volume: 2, P: 1451-1463
Using rare genetic mutations to revisit structural brain asymmetry

Asymmetry is a key organising principle of the brain. Here the authors leveraged rare genetic mutations to revisit structural brain asymmetry showing the planum temporale is susceptible to deletions & duplications of specific gene sets.

Jakub Kopal
Kuldeep Kumar
Danilo Bzdok
ResearchOpen Access26 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Author Correction: Using rare genetic mutations to revisit structural brain asymmetry

Jakub Kopal
Kuldeep Kumar
Danilo Bzdok
Amendments and CorrectionsOpen Access10 Apr 2024
Nature Communications

Volume: 15, P: 1
1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Ida E. Sønderby
Dennis van der Meer
Marianne B. M. van den Bree
ResearchOpen Access22 Mar 2021
Translational Psychiatry

Volume: 11, P: 1-16
Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence

Kopal and colleagues built computational bridges between rare CNVs in a clinical dataset and their deep phenotypic profiling in ~40,000 UK Biobank participants. Results show that CNVs are associated with many organ systems across the entire body.

Jakub Kopal
Kuldeep Kumar
Danilo Bzdok
Research02 Mar 2023
Nature Human Behaviour

Volume: 7, P: 1001-1017
ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Paul M. Thompson
Neda Jahanshad
Vladimir Zelman
ReviewsOpen Access20 Mar 2020
Translational Psychiatry

Volume: 10, P: 1-28
Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Cortex morphology varies with age, cognitive function, and in neurological and psychiatric diseases. Here the authors report 160 genome-wide significant associations with thickness, surface area and volume of the total cortex and 34 cortical regions from a GWAS meta-analysis in 22,824 adults.

Edith Hofer
Gennady V. Roshchupkin
Sudha Seshadri
ResearchOpen Access22 Sept 2020
Nature Communications

Volume: 11, P: 1-16
Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E Sønderby
Ómar Gústafsson
Ole A. Andreassen
ResearchOpen Access03 Oct 2018
Molecular Psychiatry

Volume: 25, P: 584-602
No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank

Rune Boen
Tobias Kaufmann
Ida E. Sønderby
ResearchOpen Access18 Feb 2023
Translational Psychiatry

Volume: 13, P: 1-6
The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

A GWAS study of European individuals uncovers genetic associations between whole-body MRI derived measures and cardiometabolic diseases and highlights the key role of liver fat in cardiometabolic health.

Dennis van der Meer
Tiril P. Gurholt
Ole A. Andreassen
ResearchOpen Access19 Nov 2022
Communications Biology

Volume: 5, P: 1-10
Population-based body–brain mapping links brain morphology with anthropometrics and body composition

Tiril P. Gurholt
Tobias Kaufmann
Ole A. Andreassen
ResearchOpen Access18 May 2021
Translational Psychiatry

Volume: 11, P: 1-12
Genetic control of variability in subcortical and intracranial volumes

Aldo Córdova-Palomera
Dennis van der Meer
Lars T. Westlye
Research11 Feb 2020
Molecular Psychiatry

Volume: 26, P: 3876-3883
Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

Dennis van der Meer
Jaroslav Rokicki
Lars T. Westlye
ResearchOpen Access02 Oct 2018
Molecular Psychiatry

Volume: 25, P: 3053-3065
Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

Aldo Córdova-Palomera
Tobias Kaufmann
Lars T. Westlye
Research27 Apr 2018
European Journal of Human Genetics

Volume: 26, P: 1049-1059
Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes

Tomasz Stokowy
Tatiana Polushina
Vidar M. Steen
ResearchOpen Access02 May 2018
Scientific Reports

Volume: 8, P: 1-8
Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder

Timothy Hughes
Ida E. Sønderby
Srdjan Djurovic
ResearchOpen Access08 Oct 2018
Translational Psychiatry

Volume: 8, P: 1-12
Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Ida E. Sønderby
Ómar Gústafsson
Ole A. Andreassen
Amendments and Corrections31 Jan 2019
Molecular Psychiatry

Volume: 25, P: 692-695
Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

Xudong Wu
Ida Holst Bekker-Jensen
Kristian Helin
Research16 Oct 2015
Cell Research

Volume: 25, P: 1205-1218

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Pleiotropic and sex-specific genetic mechanisms of circulating metabolic markers

Unraveling the link between CNVs, cognition and individual neuroimaging deviation scores from a population-based reference cohort

Using rare genetic mutations to revisit structural brain asymmetry

Author Correction: Using rare genetic mutations to revisit structural brain asymmetry

1q21.1 distal copy number variants are associated with cerebral and cognitive alterations in humans

Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

No signs of neurodegenerative effects in 15q11.2 BP1-BP2 copy number variant carriers in the UK Biobank

The link between liver fat and cardiometabolic diseases is highlighted by genome-wide association study of MRI-derived measures of body composition

Population-based body–brain mapping links brain morphology with anthropometrics and body composition

Genetic control of variability in subcortical and intracranial volumes

Brain scans from 21,297 individuals reveal the genetic architecture of hippocampal subfield volumes

Effects of autozygosity and schizophrenia polygenic risk on cognitive and brain developmental trajectories

Genetic variation in 117 myelination-related genes in schizophrenia: Replication of association to lipid biosynthesis genes

Elevated expression of a minor isoform of ANK3 is a risk factor for bipolar disorder

Correction: Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia

Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals

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