Tubulointerstitial hypoxia is increasingly recognized to have a key role in the progression of chronic kidney disease to end-stage renal disease. In this Review, Mimura and Nangaku discuss the different factors that contribute to the development of hypoxia in the tubulointerstitium and the susceptibility of different kidney cell types to hypoxia. Methods to detect hypoxia and potential therapeutic approaches to target chronic hypoxia in the kidney are also described.
- Imari Mimura
- Masaomi Nangaku
