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Editorial Expression of Concern: ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

Dipak Maskey
Shida Yousefi
Hans-Uwe Simon
Amendments and CorrectionsOpen Access11 Mar 2025
Nature Communications

Volume: 16, P: 1
Catapult-like release of mitochondrial DNA by eosinophils contributes to antibacterial defense

Yousefi et al. reveal a new function of eosinophils and suggest they have an antibacterial role in the gut. The cells fire spurts of mitochondrial DNA and granule proteins in response to infection, entrapping and killing the extracellular bacteria (pages 910–911).

Shida Yousefi
Jeffrey A Gold
Hans-Uwe Simon
Research10 Aug 2008
Nature Medicine

Volume: 14, P: 949-953
Role of bradykinins and nitric oxide in the AT₂ receptor-mediated hypotension

B Sosa-Canache
M Cierco
A Israel
Research17 May 2000
Journal of Human Hypertension

Volume: 14, P: S40-S46
ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

The protein ATG5 is known to be involved in the formation of autophagosomes. Here, Maskey et al. identify a new role of ATG5 in response to drug-induced DNA damage whereby ATG5 translocates to the nucleus, leading to chromosome misalignment and mitotic catastrophe.

Dipak Maskey
Shida Yousefi
Hans-Uwe Simon
ResearchOpen Access15 Aug 2013
Nature Communications

Volume: 4, P: 1-14
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Shida Yousefi
Remo Perozzo
Hans-Uwe Simon
Research24 Sept 2006
Nature Cell Biology

Volume: 8, P: 1124-1132