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Showing 1–9 of 9 results
Advanced filters: Author: In-Ja Byeon Clear advanced filters

  • Vpr is a HIV-1 accessory virulence factor that also interacts with the human DNA repair protein hHR23A. Here, the authors present the structure of Vpr in complex with the C-terminal half of hHR23A comprising the XPC-binding and ubiquitin-associated domains, which reveals that hHR23A interacts with the DCAF1-binding and not the substrate-binding Vpr surface and further illustrates how Vpr acts as a versatile structural adapter that targets diverse DNA repair pathways.

    • In-Ja L. Byeon
    • Guillermo Calero
    • Angela M. Gronenborn
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The host cell factor cyclophilin A (CypA) interacts with the HIV-1 capsid and regulates infectivity. Here the authors combine cryo-EM, solid-state NMR and all-atom MD simulations, identifying an interaction interface between CypA and the HIV capsid that stabilizes the viral capsid and regulates infectivity.

    • Chuang Liu
    • Juan R. Perilla
    • Peijun Zhang
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Mdm2 negatively regulates tumor suppressor p53 via binding to the transactivation and the DNA-binding domains of p53. Now work reveals a novel interaction between the N-terminal domain of Mdm2 and the extreme C-terminal region of p53, a region that bears the sites of many post-translational modifications that inhibit the Mdm2-p53 interaction.

    • Masha V Poyurovsky
    • Chen Katz
    • Carol Prives
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 982-989

  • The huntingtin protein (HTT) contains a polyQ tract preceded by an N-terminal flanking sequence (HTTNT) that contributes to HTT aggregation. Now the role of HTTNT in aggregation is explored in vitro, revealing a complex, multistep pathway initiated when polyQ disrupts HTTNT structure, enhancing the latter's assembly into prefibrillar aggregates. Within these intermediates, subsequent interactions of the polyQ moieties drive further assembly into compact amyloid aggregates.

    • Ashwani K Thakur
    • Murali Jayaraman
    • Ronald Wetzel
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 380-389

  • The process of HIV particle maturation involves complex molecular transitions. Here the authors combine NMR spectroscopy, cryo-EM, and molecular dynamics simulations to provide insight into the conformational equilibria in CA-SP1 assemblies relevant to HIV-1 maturation intermediates formation.

    • Mingzhang Wang
    • Caitlin M. Quinn
    • Tatyana Polenova
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12