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Showing 1–3 of 3 results
Advanced filters: Author: Iryna V. Sadkova Clear advanced filters
  • Methyl sulfone is a standard polar substituent used in chemistry and can be found in different agro chemicals or drugs but due to lack of convenient and efficient chemical approaches to them, heteroaromatic methyl sulfones are less investigated. Here the authors report a reagent to access previously unknown heteroaromatic methyl sulfones.

    • Yaroslav Poplavskyi
    • Vasyl Ripenko
    • Pavel K. Mykhailiuk
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-10
  • The phenyl ring is a basic structural element in chemistry. Here, the authors show the design, synthesis, and validation of 2-oxabicyclo[2.2.2]octane as a new saturated bioisostere with improved physicochemical properties

    • Vadym V. Levterov
    • Yaroslav Panasiuk
    • Pavel K. Mykhailiuk
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10
  • A general and scalable approach to prepare functionalized bicyclo[1.1.1]pentanes is reported. The key reaction between alkyl iodides and propellane is performed in flow and requires just light; no catalysts, initiators or additives are needed. Combined with the subsequent functionalization, >300 bicyclo[1.1.1]pentanes for medicinal chemistry have been prepared.

    • Vasyl Ripenko
    • Vadym Sham
    • Pavel K. Mykhailiuk
    ResearchOpen Access
    Nature Synthesis
    Volume: 3, P: 1538-1549