T cells undergo age-related changes that impair their organismal functions. Here Soto-Heredero et al. show that regulatory T cells characterized by the expression of KLRG1 accumulate with age in both mice and humans and exhibit features including mitochondrial decline and an inflammatory phenotype.
- Gonzalo Soto-Heredero
- Enrique Gabandé-Rodríguez
- María Mittelbrunn
