Nature Search

Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci

Casparian strips are extracellular diffusion barriers in plant roots. Here, Barbosa et al. provide evidence that CASP proteins shape Casparian strips by displacing vesicle tethering factors and organizing cell wall formation

Inês Catarina Ramos Barbosa
Damien De Bellis
Niko Geldner
ResearchOpen Access23 Mar 2023
Nature Communications

Volume: 14, P: 1-18
Exon-junction complex association with stalled ribosomes and slow translation-independent disassembly

Bensaude et al. use a split luciferase approach to show that exon-junction complex assembly and disassembly occur faster when they are translation-dependent than when they are translation-independent; and they uncover an association with ribosomes.

Olivier Bensaude
Isabelle Barbosa
Hervé Le Hir
ResearchOpen Access17 May 2024
Nature Communications

Volume: 15, P: 1-14
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

Aymeric Lanore
Christelle Tesson
Eva Camgrand
ResearchOpen Access02 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1-14
The exon junction complex differentially marks spliced junctions

The exon junction complex (EJC) is found on spliced mRNAs and influences post-transcriptional regulation. It is now shown that in Drosophila melanogaster, the EJC is bound to some but not all spliced junctions, suggesting that its assembly by the splicing machinery is a regulated process.

Jérôme Saulière
Nazmul Haque
Hervé Le Hir
Research05 Sept 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1269-1271
Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

Exon junction complexes (EJCs) that mark untranslated mRNA are involved in transport, translation and nonsense-mediated mRNA decay. Here the authors show centrosomal localization of EJCs which appears to be required for both the localization of NIN mRNA around centrosomes and ciliogenesis.

Oh Sung Kwon
Rahul Mishra
Hervé Le Hir
ResearchOpen Access01 Mar 2021
Nature Communications

Volume: 12, P: 1-16
Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

Many job sectors classified as ‘essential’ have continued operating with limited restrictions during the COVID-19 pandemic, potentially placing workers at higher risk of infection. Here, the authors show that seropositivity rates in workers vary widely across and between job sectors in Geneva, Switzerland.

Silvia Stringhini
María-Eugenia Zaballa
Idris Guessous
ResearchOpen Access08 Jun 2021
Nature Communications

Volume: 12, P: 1-7
Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events

Zhen Wang
Lionel Ballut
Hervé Le Hir
ResearchOpen Access22 Jun 2018
Scientific Reports

Volume: 8, P: 1-8
Association between MBL2 gene polymorphism and protection against leprosy in a population of northeastern brazil: a case-control study

Karla Regina Celestino Nogueira
Heloisa de Almeida Freitas
Carolinne de Sales Marques
ResearchOpen Access15 Jul 2025
Scientific Reports

Volume: 15, P: 1-10
Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

The exon junction complex (EJC) links splicing to downstream events including mRNA localization, translation and stability. A combination of in vitro and in vivo approaches were used to identify the splicing factor CWC22 as a direct partner of EJC component eIF4AIII in flies and humans and to demonstrate its functions in preventing eIF4AIII binding to RNA and in escorting eIF4AIII to active spliceosomes before EJC assembly.

Isabelle Barbosa
Nazmul Haque
Hervé Le Hir
Research09 Sept 2012
Nature Structural & Molecular Biology

Volume: 19, P: 983-990
CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

The exon junction complex (EJC) has a crucial role in various post-transcriptional control mechanisms. CLIP-Seq analysis of the human EJC component eIF4AIII has revealed peaks in canonical EJC-binding regions, including ~24 nucleotides upstream of exon junctions. Surprisingly, EJCs are also present elsewhere in the transcriptome, uncovering an unexpected heterogeneity of EJC association with mRNAs.

Jérôme Saulière
Valentine Murigneux
Hervé Le Hir
Research21 Oct 2012
Nature Structural & Molecular Biology

Volume: 19, P: 1124-1131
At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Munib Mesinovic
Xin Ci Wong
David Zucman
ResearchOpen Access16 Jul 2024
Scientific Reports

Volume: 14, P: 1-43
Critical assessment of protein intrinsic disorder prediction

Results are presented from the first Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment, a community-based blind test to determine the state of the art in predicting intrinsically disordered regions in proteins.

Marco Necci
Damiano Piovesan
Silvio C. E. Tosatto
ResearchOpen Access19 Apr 2021
Nature Methods

Volume: 18, P: 472-481
Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

German Demidov
Burcu Yaldiz
Steven Laurie
ResearchOpen Access26 Oct 2024
npj Genomic Medicine

Volume: 9, P: 1-24
Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma

Carmela Dantas-Barbosa
Tom Lesluyes
Jean-Yves Blay
ResearchOpen Access12 Oct 2017
British Journal of Cancer

Volume: 117, P: 1787-1797
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response

Elisabeth Guillemet
Alain Leréec
Nalini Ramarao
ResearchOpen Access20 Jul 2016
Scientific Reports

Volume: 6, P: 1-12
Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor

Transcription factor NF-ĸB is a key regulator of immunity in mammals, but its function in protists like Capsaspora and choanoflagellates is not known. Here, Leah Williams et al. characterize and compare the structure, activity, and regulation of NF-ĸB from Capsaspora and one choanoflagellate, providing further insight into the origins of NF-ĸB.

Leah M. Williams
Sainetra Sridhar
Thomas D. Gilmore
ResearchOpen Access16 Dec 2021
Communications Biology

Volume: 4, P: 1-14
Pandemic beyond the virus: maternal COVID-related postnatal stress is associated with infant temperament

Catherine Bianco
Ayesha Sania
Dima Amso
Research20 Apr 2022
Pediatric Research

Volume: 93, P: 253-259

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Directed growth and fusion of membrane-wall microdomains requires CASP-mediated inhibition and displacement of secretory foci

Exon-junction complex association with stalled ribosomes and slow translation-independent disassembly

Diminishing benefits of urban living for children and adolescents’ growth and development

Classification of GBA1 variants and their impact on Parkinson’s disease: an in silico score analysis

The exon junction complex differentially marks spliced junctions

Exon junction complex dependent mRNA localization is linked to centrosome organization during ciliogenesis

Large variation in anti-SARS-CoV-2 antibody prevalence among essential workers in Geneva, Switzerland

Exon Junction Complexes can have distinct functional flavours to regulate specific splicing events

Association between MBL2 gene polymorphism and protection against leprosy in a population of northeastern brazil: a case-control study

Human CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assembly

CLIP-seq of eIF4AIII reveals transcriptome-wide mapping of the human exon junction complex

At-admission prediction of mortality and pulmonary embolism in an international cohort of hospitalised patients with COVID-19 using statistical and machine learning methods

Critical assessment of protein intrinsic disorder prediction

Comprehensive reanalysis for CNVs in ES data from unsolved rare disease cases results in new diagnoses

Expression and role of TYRO3 and AXL as potential therapeutical targets in leiomyosarcoma

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

The bacterial DNA repair protein Mfd confers resistance to the host nitrogen immune response

Comparison of NF-κB from the protists Capsaspora owczarzaki and Acanthoeca spectabilis reveals extensive evolutionary diversification of this transcription factor

Pandemic beyond the virus: maternal COVID-related postnatal stress is associated with infant temperament

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