To study the onset of carcinogenesis, the authors use an optogenetics approach to selectively activate with light the Src oncoprotein in cells of an epithelium with a good control in time and space. The transformed cells collectively extrude as a tridimensional aggregate from the cell sheet while remaining alive and in parallel cells of the monolayer converge toward the locus of extrusion.
- Sarah Moitrier
- Nastassia Pricoupenko
- Isabelle Bonnet
