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Advanced filters: Author: Isha Mehta Clear advanced filters

Determinants of successful AAV-vectored delivery of HIV-1 bNAbs in early life

A single dose of an adeno-associated virus vector encoding an HIV-1 broadly neutralizing antibody given shortly after birth results in persistent antibody expression and protection from infection in rhesus macaque models of human HIV-1 transmission through breastfeeding and sexual intercourse.

Amir Ardeshir
Daniel O’Hagan
Mauricio A. Martins
ResearchOpen Access30 Jul 2025
Nature

Volume: 645, P: 1020-1028
The survival of B cells is compromised in kidney disease

Kidney disease compromises the humoral immune response to vaccines and infections. Here authors show in multiple murine kidney disease models that apoptosis of germinal center B cells via hippuric-acid-driven loss of mitochondrial membrane potential is a central cause of diminished antibody response.

Doureradjou Peroumal
Chetan V. Jawale
Partha S. Biswas
ResearchOpen Access30 Dec 2024
Nature Communications

Volume: 15, P: 1-19
Spatial microniches of IL-2 combine with IL-10 to drive lung migratory T_H2 cells in response to inhaled allergen

Poholek and colleagues show that, during allergic airway inflammation, the transcription factor Blimp-1 regulates CD4⁺T_H2 cell migration to the lung and define anatomical locations in mediastinal lymph nodes where IL-2 programming induces T_H2 cell polarization.

Kun He
Hanxi Xiao
Amanda C. Poholek
Research11 Oct 2024
Nature Immunology

Volume: 25, P: 2124-2139
Integrating DNA methylation and gene expression data in a single gene network using the iNETgrate package

Sogand Sajedi
Ghazal Ebrahimi
Habil Zare
ResearchOpen Access08 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
Surface stabilized atorvastatin nanocrystals with improved bioavailability, safety and antihyperlipidemic potential

Manu Sharma
Isha Mehta
ResearchOpen Access06 Nov 2019
Scientific Reports

Volume: 9, P: 1-11