Nature Search

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

The role of circular RNAs (circRNAs) in modulating gene expression in cancer remains to be investigated. Here, the authors perform whole transcriptome sequencing in 104 primary neuroblastomas and reveal the involvement of MYCN in regulating circRNAs.

Steffen Fuchs
Clara Danßmann
Johannes H. Schulte
ResearchOpen Access04 Jul 2023
Nature Communications

Volume: 14, P: 1-21
RNA recording in single bacterial cells using reprogrammed tracrRNAs

RNA transcripts in bacteria are recorded as DNA modifications using a base editor.

Chunlei Jiao
Claas Reckstadt
Chase L. Beisel
ResearchOpen Access05 Jan 2023
Nature Biotechnology

Volume: 41, P: 1107-1116
CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

CAR-T cell therapy targeting CD19 is not as efficient to treat lymphoma with nodal dissemination as it is for B cell leukaemia. Here, the authors generate CAR-T cells against CXCR5 and show they inhibit tumour growth by depleting both B and follicular T helper cells in lymphoma models.

Mario Bunse
Janina Pfeilschifter
Uta E. Höpken
ResearchOpen Access11 Jan 2021
Nature Communications

Volume: 12, P: 1-19
The landscape of genomic alterations across childhood cancers

Analyses of genomes from 914 children, adolescents, and young adults provide a comprehensive resource of genomic alterations across a spectrum of common childhood cancers.

Susanne N. Gröbner
Barbara C. Worst
Stefan M. Pfister
ResearchOpen Access28 Feb 2018
Nature

Volume: 555, P: 321-327
Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen

Studying emerging pathogens is often challenging due to the lack of information. Here the authors show that dual RNA-seq, profiling the host and pathogen transcriptome simultaneously, helps uncovering the biology of Orientia tsutsugamushi, a major cause of febrile illness in South-East Asia, and its interaction with the host.

Bozena Mika-Gospodorz
Suparat Giengkam
Jeanne Salje
ResearchOpen Access03 Jul 2020
Nature Communications

Volume: 11, P: 1-14
Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella

Single-cell RNA-seq finds a pro-inflammatory M1 polarized immune response in macrophages infected with actively replicating Salmonella and an anti-inflammatory M2-like response in uninfected bystanders or cells with non-replicating bacteria.

Antoine-Emmanuel Saliba
Lei Li
Jörg Vogel
Research14 Nov 2016
Nature Microbiology

Volume: 2, P: 1-8
Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research

Overcoming key hurdles for the development of next-generation anaerobic cultivation methods could have major impacts on microbial community research and applications.

Thomas Clavel
Franziska Faber
Lisa Maier
Reviews29 Apr 2025
Nature Biotechnology

Volume: 43, P: 878-888
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Here authors show that GDF15, a cytokine that is produced by cancer cells, prevents T cells from extravasation into the tumour microenvironment. Low availability of T cells in GDF-15-expressing tumours thus precludes effective immune therapy.

Markus Haake
Beatrice Haack
Jörg Wischhusen
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
Cross-species RNA-seq for deciphering host–microbe interactions

Interactions between microorganisms and their hosts are highly context dependent and contribute to both normal tissue function and infectious disease pathology. In this Review, Westermann and Vogel describe how advances in RNA sequencing techniques are providing molecular insights into host–microbe interactions, including advances in cross-species and single-cell transcriptomics.

Alexander J. Westermann
Jörg Vogel
Reviews17 Feb 2021
Nature Reviews Genetics

Volume: 22, P: 361-378
Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions

Using dual RNA-seq technology to profile RNA expression simultaneously in the bacterial pathogen Salmonella and its host during infection reveals molecular phenotypes of small noncoding RNAs in the infection process.

Alexander J. Westermann
Konrad U. Förstner
Jörg Vogel
Research20 Jan 2016
Nature

Volume: 529, P: 496-501
Author Correction: The landscape of genomic alterations across childhood cancers

Susanne N. Gröbner
Barbara C. Worst
Stephanie Sungalee
Amendments and Corrections06 Jun 2018
Nature

Volume: 559, P: E10
Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

Simon Raffel
Mattia Falcone
Andreas Trumpp
Amendments and Corrections01 Aug 2018
Nature

Volume: 560, P: E28
CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

The mechanism by which adenosine monophosphate modulates dynein ATPase-mediated ciliary and flagellar beating remains obscure. Here the authors identify an axonemal module including cilia and flagella associated protein 45 that supports adenine nucleotide homeostasis and underlies a human ciliopathy

Gerard W. Dougherty
Katsutoshi Mizuno
Heymut Omran
ResearchOpen Access02 Nov 2020
Nature Communications

Volume: 11, P: 1-20
Dual RNA-seq of pathogen and host

The infection process is accompanied by widespread changes in gene expression in both host and pathogen. Here, Vogel and colleagues explore the feasibility of simultaneously analysing the transcriptomes of both host and pathogen using RNA deep-sequencing approaches.

Alexander J. Westermann
Stanislaw A. Gorski
Jörg Vogel
Reviews14 Aug 2012
Nature Reviews Microbiology

Volume: 10, P: 618-630
Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy

Sophia Gross
Jana Ihlow
Jörg Westermann
ResearchOpen Access16 Sept 2024
Blood Cancer Journal

Volume: 14, P: 1-10
TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

The key regulator of lysosomal biogenesis, Tfeb, is shown to directly induce Irg1 transcription and mitochondrial itaconate production to restrain bacterial growth in macrophages.

Ev-Marie Schuster
Maximilian W. Epple
Angelika S. Rambold
ResearchOpen Access21 Jul 2022
Nature Metabolism

Volume: 4, P: 856-866
BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

The mechanistic basis for the role of the metabolic enzyme BCAA transaminase 1 (BCAT1) in acute myeloid leukaemias.

Simon Raffel
Mattia Falcone
Andreas Trumpp
Research08 Nov 2017
Nature

Volume: 551, P: 384-388
Measurable residual disease quantification in adult patients with KMT2A-rearranged acute lymphoblastic leukemia

Thomas Burmeister
Aeint-Steffen Ströh
Monika Brüggemann
ResearchOpen Access22 Mar 2024
Leukemia

Volume: 38, P: 1600-1603
Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models

Chi Wang Ip
Jörg Wischhusen
Research HighlightsOpen Access20 Nov 2023
Signal Transduction and Targeted Therapy

Volume: 8, P: 1-3
High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome

Alexander Schramm
Volker von Schuetz
Lothar Schweigerer
Research06 Dec 2004
Oncogene

Volume: 24, P: 680-687

Search

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

RNA recording in single bacterial cells using reprogrammed tracrRNAs

CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin’s lymphoma and tumor-supportive follicular T helper cells

The landscape of genomic alterations across childhood cancers

Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen

Single-cell RNA-seq ties macrophage polarization to growth rate of intracellular Salmonella

Enabling next-generation anaerobic cultivation through biotechnology to advance functional microbiome research

Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment

Cross-species RNA-seq for deciphering host–microbe interactions

Dual RNA-seq unveils noncoding RNA functions in host–pathogen interactions

Author Correction: The landscape of genomic alterations across childhood cancers

Author Correction: BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

CFAP45 deficiency causes situs abnormalities and asthenospermia by disrupting an axonemal adenine nucleotide homeostasis module

Dual RNA-seq of pathogen and host

Therapy-related AML: long-term outcome in a large cohort of AML-patients with intensive and non-intensive therapy

TFEB induces mitochondrial itaconate synthesis to suppress bacterial growth in macrophages

BCAT1 restricts αKG levels in AML stem cells leading to IDH^mut-like DNA hypermethylation

Measurable residual disease quantification in adult patients with KMT2A-rearranged acute lymphoblastic leukemia

Versatile guardians: regenerative regulatory T cells in Parkinson’s disease rodent models

High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome

Search

Quick links

Search

Filter By:

Search

Quick links