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Electronic highways were realized by means of epitaxially grown graphene nanoribbons on SiC substrates. Here, the authors use spatially-resolved two-point probe and conductive AFM measurements, supplemented by tight-binding calculations, to image the one-dimensional ballistic transport channels.

Radical Fe^II/α-ketoglutarate-dependent halogenases are powerful biocatalysts for C–H functionalization. Here, the authors reveal the mechanistic basis for chemoselectivity in a lysine halogenase.

Wafer bonding has allowed the synthesis of twisted interfaces which support polar discontinuities in ferroelectric lithium niobate. Two-dimensional sheet conductivity arises but is suppressed when twist angles lead to interfacial lattice aperiodicity.

Genome-wide association analyses using data from 19 biobanks identify variants influencing risk of thyroid diseases and yield polygenic risk scores associated with features of aggressive thyroid cancer.

Tuning the electronic properties of nanocatalysts by doping them with uniformly dispersed hetero-metal atoms is an effective way to improve catalytic performance. Here, the authors show that weakening the Cu–O bond energy in CuO nanocatalysts boosts the efficiency of NH₃ oxidation.

A consensus cell type atlas for the fly brain provides both an intellectual framework and open-source toolchains for brain-scale comparative connectomics.

The nature of localized interlayer excitons (LIXs) in moiré superlattices is still elusive Here, the authors propose a donor-acceptor pair mechanism for LIXs in MoSe₂/WSe₂ heterobilayers.

Reduced-dimensional halide perovskites are promising for light-emitting diodes but suffer from photo-degradation. Here Quan et al. identify the edge of the perovskite nanoplatelets as the degradation channels and use phosphine oxides to passivate the edges and boost device performance and lifetime.

The broken-symmetry edge states that are the hallmark of the quantum Hall effect in graphene have eluded spatial measurements. Here, the authors spatially map the quantum Hall broken-symmetry edge states using atomic force microscopy and show a gapped ground state proceeding from the bulk through to the quantum Hall edge boundary.

Sonomate is a digital assistant for ultrasound examinations, supporting users through feedback, anatomical recognition and interactive question answering.

The band edge positions of semiconductors decide their optoelectronic properties. Here, the authors establish a simple ligand exchange strategy to tune the band edge positions of colloidal PbS semiconductor quantum dots, revealing clear relationships between surface chemistry and band edge position.

Particle fusion is a promising process for constructing nanomaterials, but challenging to control in synthetic systems. Here, the authors report a method for kinetically regulated particle fusion controlled by variation in polymer chain length.

Unusual properties arise in transition metal dichalcogenides as dimensionality decreases. Here, the authors introduce a templated growth approach to precisely control the width of MoS₂nanowires on a substrate, allowing them to reveal a relationship between size and electronic properties.

Creating magnetic order in non-magnetic materials is a long-standing goal. In this article, through density-functional calculations, the authors show that silicon surfaces with adsorbed gold atoms can become magnetic due to ordering of the spins of atoms at the step edges, paving the way towards new materials for spintronics.

Lithium-ion battery cathode lifetime is limited by large expansion and contraction during cycling. This study uses electrochemical activation to suppress collapse in LiNi_0.9Mn_0.1O₂ cathodes, achieving improved capacity and cycle life.

Major sediment-hosted base metal deposits are located within 200 km of the border between thick and thin lithosphere, according to statistical comparisons between global lithospheric thickness and known deposit locations.

An allosteric site on the E3 ligase adapter cereblon can be targeted to modulate the efficacy of cereblon in targeted protein degradation applications.

Quantum Hall interferometers have proven to be a useful platform for the study of fractional statistics. Here, the authors experimentally study the effect of Coulomb interactions between bulk and edge charges on the interferometer behavior, validating previous theoretical predictions.

Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables monitoring of minimal residual disease and immunotherapy response in settings of low tumor burden.

Many photo-induced processes such as photosynthesis occur in organic molecules, but their femtosecond excited-state dynamics are difficult to track. Here, the authors exploit the element and site selectivity of soft X-ray absorption to sensitively follow the ultrafast ππ*/nπ* electronic relaxation of hetero-organic molecules.

deepmriprep leverages neural networks to enable voxel-based morphometry preprocessing of MRI data that is 37× faster than existing methods while achieving comparable accuracy in segmentation, registration and final statistical maps across large datasets.

Using infant fMRI, the authors show that, by 2 months of age, representations in high-level visual cortex encode visual categories that align with deep neural networks, and lateral object-selective regions are later to develop.

Liquid phase exfoliation is frequently used to produce 2D nanosheets from layered materials, but determining sheet thickness in situhas not been possible. Here, the authors report a spectroscopic technique capable of determining sheet thickness, sheet lengths and concentrations directly from dispersions.

A flexible micro-electrocorticography brain–computer interface that integrates a 256 × 256 array of electrodes, signal processing, data telemetry and wireless powering on a single complementary metal–oxide–semiconductor substrate can provide stable, chronic in vivo recordings.

Here, the authors combine bioinformatic, mass spectrometric, and sequencing-based mapping tools to identify previously undescribed phosphorothioate epigenetic systems widespread in the human gut microbiome.

Understanding the dynamics of light-induced carriers is vital for employing two-dimensional materials in optoelectronic applications. Here, the authors use a sub diffraction-limit optical technique to reveal the excitonic properties of monolayer molybdenum disulfide at the nanoscale.

Rearrangements govern many properties of materials and molecules, but it has been largely unexplored how to create flexible structures from the bottom up. Here, the authors use colloidal particles to explore how to guide the kinetic self-assembly pathways into ordered structures that maintain flexibility.

Creating accurate digital twins and controlling nonlinear systems displaying chaotic dynamics is challenging due to high system sensitivity to initial conditions and perturbations. The authors introduce a nonlinear controller for chaotic systems, based on next-generation reservoir computing, with improved accuracy, energy cost, and suitable for implementation with field-programmable gate arrays.

Genomic analyses applied to 14 childhood- and adult-onset psychiatric disorders identifies five underlying genomic factors that explain the majority of the genetic variance of the individual disorders.

¹³⁴Ce and ¹³⁴La have great potential as companion diagnostic isotopes for radiotherapeutics labelled with α-emitting ²²⁵Ac and ²²⁷Th. Now, by controlling the Ce^III/Ce^IV redox couple, the large-scale production, purification and characterization of ¹³⁴Ce- and ¹³⁴La-based radiolabels has been achieved and their use for in vivo positron emission tomography is demonstrated.

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Here the authors perturb genes linked to schizophrenia risk in human neurons. They find that single perturbations share common downstream effects on gene networks, while joint perturbations result in downstream effects being saturated.

The functions of the vast majority of brain-expressed spliced isoforms are unknown. Here the authors describe an isoform-resolution perturbation system coupled to a single cell transcriptomics read-out, and through this approach identify neuronal microexons that control autism-linked signatures underlying neuronal maturation and function

Mapping the operational chemical, physical and electronic structure of an oxygen evolution electrocatalyst at the nanoscale links the properties of the material with the observed oxygen evolution activity.

Transition metal oxides serve as important electrocatalysts for the oxygen evolution reaction, although Co-based oxides typically undergo pH-dependent dynamic surface reconstruction under catalytic conditions. Now the correlations between Co redox dynamics, flat band potential and Co oxidation state changes have been established to explain the pH dependency of oxygen evolution activity.

Operando scanning tunneling microscopy under near-industrial conditions and density functional theory demonstrate that CH3SH hydrodesulfurization occurs via a new methyl transfer pathway on the Co-substituted S edges of a CoMoS model catalyst.

This study uses near-field terahertz microscopy to reveal how hidden resonant modes in gold metasurfaces trap and intensify light, showing size-dependent nonlocal effects that shape bound states in the continuum.

This study explores the use of quantum computing to address multi-objective optimization challenges. By using a low-depth quantum approximate optimization algorithm to approximate the optimal Pareto front of multi-objective weighted max-cut problems, the authors demonstrate promising results—both in simulation and on IBM Quantum hardware—surpassing classical approaches.

Existing methods for the modification of exosomes adversely impact structures and functions of exosomal proteins and membranes. Here, the authors develop a chemically engineered platform by leveraging the synergistic interplay between CD38’s catalytic activity and the covalent inhibitor 2'-Cl-araNAD⁺.

It is known that the primary sensory neurons that mediate tactile sensation exhibit elaborate receptive fields because of dendritic branching in the skin. In this study, the authors show that such branching allows neurons that innervate the human fingertips to extract geometric features of touched objects and signal them via both temporal and intensity codes.

Integrated single-cell and spatial data analysis, combined with bidirectional CRISPR screens, identify the transcription factor GLIS3 as a key driver of chronic inflammation and fibrosis and a potential marker of disease severity in patients with ulcerative colitis.

The accurate structure of the platelet defects in diamond is now resolved by transmission electron microscopy, and, out of all the proposed models, it agrees well with the zigzag atomic model.

Radiation reaction (RR) on particles in strong fields is the subject of intense experimental research, but previous efforts lacked statistical significance due to the extreme regimes required. Here, the authors report a 5σ observation of RR and obtain strong, quantitative evidence favouring quantum models over classical, using an all-optical setup where electrons are accelerated by a laser in a gas jet before colliding with a second, intense pulse.