The bio-incompatible characteristics of standard peritoneal dialysis solutions, such as high glucose concentration and nonphysiologic pH, have spurred the development of a new generation of more-biocompatible solutions. In this overview of available clinical data, the advantages and drawbacks of using fluids that contain amino acids or icodextrin, or that have a neutral pH, are debated. The authors conclude that the new peritoneal dialysis solutions hold great promise for improving ultrafiltration and clinical outcomes.
- Pieter M ter Wee
- Frans J van Ittersum
