The La protein binds precursor tRNAs at their 3′ ends, thus facilitating maturation. Crystal structures indicate that the most obvious RNA-recognition motif does not bind this pre-tRNA tail, but studies now indicate that La has two distinct binding sites for the pre-mRNA. Recognition through these two sites may help distinguish precursor from product, an idea supported by biochemical studies here.
- Mark A Bayfield
- Richard J Maraia
