Nature Search

Nature of the Ribosomes Present in Bacteria and Yeast: A Re-Appraisal

T. J. BOWEN
S. DAGLEY
D. G. WILD
Research25 Feb 1961
Nature

Volume: 189, P: 638-640
Nature of the Circulating Thyroid Hormone - Plasma Protein Complex

A. H. GORDON
J. GROSS
ROSALIND PITT-RIVERS
Research05 Jan 1952
Nature

Volume: 169, P: 19-20
Prof. T. Mckenny Hughes, F.R.S.

J. E. MARR
Comments & Opinion21 Jun 1917
Nature

Volume: 99, P: 326-327
Molecular basis for noncanonical transcription initiation from Np₄A alarmones

Duan and Kaushik et al. reveal the structural basis of how Escherichia coli and Thermus thermophilus RNA polymerases initiate transcription from Np₄A alarmones producing Np₄-capped transcripts. The caps form various interactions with a polymerase during initial steps, influencing capping efficiency.

Wenqian Duan
Abhishek Kaushik
Alexander Serganov
Research15 Oct 2025
Nature Chemical Biology

P: 1-11
Natural production of tritium in permeable rocks

J. N. Andrews
R. L. F. Kay
Research22 Jul 1982
Nature

Volume: 298, P: 361-363
Hughes expands in the Americas

Barbara J. Culliton
News01 Apr 1997
Nature Medicine

Volume: 3, P: 369-370
Visualization of liquid-liquid phase transitions using a tiny G-quadruplex binding protein

This study discovers human SERF2 as a key partner in stress granule formation by binding specific RNA G-quadruplexes. SERF2 and these RNAs provide a detailed structural model of protein-RNA interactions driving liquid-liquid phase separation in condensates.

Bikash R. Sahoo
Xiexiong Deng
James C. A. Bardwell
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-22
Low circulating miR-190a-5p predicts progression of chronic kidney disease

Chronic Kidney Disease affects 1 in 10 people worldwide with prevalence continuing to rise, thus there is a need to identify novel biomarkers that can add value to existing clinical and biochemical risk predictors. Here the authors identify miR190a-5p as potential indicator of kidney health and disease progression in patients with chronic kidney disease.

David P. Baird
Jinnan Zang
Laura Denby
ResearchOpen Access15 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Superinfection promotes replication and diversification of defective HIV-1 proviruses in people with non-suppressible viraemia

The authors identify defective viral particles, in people with non-suppressible HIV-1, that can replicate through superinfection and interfere with the wild-type virus. However, they show no evidence of these preventing disease progression in the individuals studied.

Vivek Hariharan
Jennifer A. White
Robert F. Siliciano
ResearchOpen Access03 Oct 2025
Nature Microbiology

P: 1-13
Design of facilitated dissociation enables timing of cytokine signalling

A fresh approach to protein design that incorporates excited intermediate states enables precise control over the lifetime of protein interactions, with potential applications in cell-signalling modulation and in biosensors and synthetic circuits.

Adam J. Broerman
Christoph Pollmann
David Baker
ResearchOpen Access24 Sept 2025
Nature

P: 1-8
Unifying machine learning and interpolation theory via interpolating neural networks

In this study, the authors combine interpolation techniques and deep learning methods, introducing Interpolating Neural Networks (INNs) to model complex systems with high accuracy and low computational cost.

Chanwook Park
Sourav Saha
Wing Kam Liu
ResearchOpen Access01 Oct 2025
Nature Communications

Volume: 16, P: 1-12
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses

The authors describe the isolation and characterization of broadly cross-neutralizing monoclonal antibodies (mAbs) against diverse H5Nx viruses from individuals who received a monovalent H5N1 vaccine 15 years ago. They identify five mAbs that potently neutralized the majority of H5 clades and protected against lethal 2.3.4.4b H5N1 infection in mice.

Alexandra A. Abu-Shmais
Gray Freeman
Sarah F. Andrews
ResearchOpen Access14 Oct 2025
Nature Microbiology

P: 1-16
Temporal and context-dependent requirements for the transcription factor Foxp3 expression in regulatory T cells

Rudensky and colleagues demonstrate a context-dependent differential requirement for Foxp3 for T_reg cell transcriptional and functional programs.

Wei Hu
Gabriel A. Dolsten
Alexander Y. Rudensky
ResearchOpen Access08 Oct 2025
Nature Immunology

P: 1-15
LARGE1 processively polymerizes length-controlled matriglycan on prodystroglycan

LARGE1 glycosyltransferase synthesizes matriglycan (xylose-glucuronate)_n on dystroglycan, and short matriglycan can cause neuromuscular disorders. Authors show that LARGE1 processively polymerizes matriglycan of defined length on prodystroglycan.

Soumya Joseph
Nicholas J. Schnicker
Kevin P. Campbell
ResearchOpen Access10 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Profiling of HIV-1 elite neutralizer cohort reveals a CD4bs bnAb for HIV-1 prevention and therapy

Klein and colleagues characterize 04_A06, a new V_H1-2-encoded broadly neutralizing antibody that has marked breadth and potency against extended multiclade HIV-1 pseudovirus panels and can maintain full viral suppression in HIV-1-infected humanized mice.

Lutz Gieselmann
Andrew T. DeLaitsch
Florian Klein
ResearchOpen Access06 Oct 2025
Nature Immunology

P: 1-14
Radiation-Widths of Nuclear Energy-Levels

D. J. HUGHES
J. A. HARVEY
Research15 May 1954
Nature

Volume: 173, P: 942-943
Spin squeezing in an ensemble of nitrogen–vacancy centres in diamond

An ensemble of spins from nitrogen–vacancy centres in diamonds is prepared in a spin-squeezed state.

Weijie Wu
Emily J. Davis
Norman Y. Yao
Research01 Oct 2025
Nature

Volume: 646, P: 74-80
A human-specific regulatory mechanism revealed in a pre-implantation model

Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

Raquel Fueyo
Sicong Wang
Joanna Wysocka
ResearchOpen Access01 Oct 2025
Nature

P: 1-10
Targeting histone H2B acetylated enhanceosomes via p300/CBP degradation in prostate cancer

This study shows that p300/CBP-dependent H2B acetylation is crucial for maintaining transcription of oncogenic gene programs in androgen receptor-driven prostate cancer.

Jie Luo
Zhixiang Chen
Arul M. Chinnaiyan
ResearchOpen Access03 Oct 2025
Nature Genetics

Volume: 57, P: 2468-2481
Identification of two related pentapeptides from the brain with potent opiate agonist activity

J. Hughes
T. W. Smith
H. R. Morris
Research01 Dec 1975
Nature

Volume: 258, P: 577-579
Spatial coding dysfunction and network instability in the aging medial entorhinal cortex

Across species, how aging leads to progressive spatial memory decline is not fully understood. This study reports dysfunctional spatial coding by aged entorhinal grid cells and networks related to impaired spatial memory and identifies implicated neuronal gene expression changes.

Charlotte S. Herber
Karishma J. B. Pratt
Lisa M. Giocomo
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-27
Native metabolomics identifies the rivulariapeptolide family of protease inhibitors

Bioactivity-guided isolation of specialized metabolites is an iterative process. Here, the authors demonstrate a native metabolomics approach that allows for fast screening of complex metabolite extracts against a protein of interest and simultaneous structure annotation.

Raphael Reher
Allegra T. Aron
Daniel Petras
ResearchOpen Access08 Aug 2022
Nature Communications

Volume: 13, P: 1-12
Structural insights into chemoresistance mutants of BCL-2 and their targeting by stapled BAD BH3 helices

Resistance mutations in BCL-2 reduce the clinical efficacy of venetoclax. DeAngelo et al. show stapled BAD BH3 peptides can retain and even enhance binding to these mutants, offering a structurally informed strategy to overcome this mechanism of cancer drug resistance.

Thomas M. DeAngelo
Utsarga Adhikary
Loren D. Walensky
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-15
Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors

The Zika viral protease NS2B-NS3 is a crucial target for antiviral drug development due to its role in processing viral polyproteins. Here, the authors utilize crystallographic fragment screening and deep mutational scanning to identify binding sites for resistance-resilient inhibitors.

Xiaomin Ni
R. Blake Richardson
Frank von Delft
ResearchOpen Access08 Oct 2025
Nature Communications

Volume: 16, P: 1-13
Molecular basis for the activation of outer dynein arms in cilia

Issa et al. show that the ciliary small guanosine triphosphatase Arl3 displaces the inhibitory regulator Shulin/DNAAF9 from the outer dynein arm, leading to motor activation.

Karim Housseini B. Issa
Muyang Ren
Girish R. Mali
ResearchOpen Access29 Sept 2025
Nature Structural & Molecular Biology

P: 1-11
Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists

Variation in responses to bacterial and viral stimuli between Batwa rainforest hunter-gatherers and Bakiga agriculturalists from Uganda suggests population-level divergence under natural selection, with hunter-gatherers disproportionately showing signatures of positive selection.

Genelle F. Harrison
Joaquin Sanz
Luis B. Barreiro
Research29 Jul 2019
Nature Ecology & Evolution

Volume: 3, P: 1253-1264
Automated classification of cellular expression in multiplexed imaging data with Nimbus

Nimbus, a deep learning model, uses a large multiplexed imaging dataset to predict the likelihood of marker positivity in single cells.

Josef Lorenz Rumberger
Noah F. Greenwald
Michael Angelo
Research08 Oct 2025
Nature Methods

Volume: 22, P: 2161-2170
Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics

Distinguishing glioblastoma and primary central nervous system lymphoma (PCNSL) remains challenging due to their overlapping pathology features. Here, the authors develop a computational tool, PICTURE, for differentiating similar pathological features enabling improved diagnosis of CNS tumours.

Junhan Zhao
Shih-Yen Lin
Kun-Hsing Yu
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-16
Natively glycosylated HIV-1 Env structure reveals new mode for antibody recognition of the CD4-binding site

Crystal structures of HIV Env trimer with native glycosylation in complex with neutralizing antibodies reveal a glycan shield of high-mannose and complex-type N-glycan and indicate a path for germline-targeting vaccine design.

Harry B Gristick
Lotta von Boehmer
Pamela J Bjorkman
Research12 Sept 2016
Nature Structural & Molecular Biology

Volume: 23, P: 906-915
Computational design of sequence-specific DNA-binding proteins

The authors develop a computational method to design small DNA-binding proteins (DBPs) that target specific sequences. Designed DBPs show structural accuracy and function in both bacterial and mammalian cells for transcriptional regulation.

Cameron J. Glasscock
Robert J. Pecoraro
David Baker
ResearchOpen Access12 Sept 2025
Nature Structural & Molecular Biology

P: 1-10
Chemical and ribosomal synthesis of atropisomeric and macrocyclic peptides with embedded quinolines

Expanding the complexity of genetically encoded peptides is a long-standing challenge at the intersection of chemistry and biology. Now it has been shown that linear peptides with a reactive N-terminal β- or γ-keto amide can be synthesized ribosomally and elaborated to generate atropisomeric and/or macrocyclic peptides with embedded pharmacophores.

Isaac J. Knudson
Taylor L. Dover
Scott J. Miller
Research17 Sept 2025
Nature Chemistry

P: 1-12
Terrestrial catastrophe caused by cometary impact at the end of Cretaceous

Kenneth J. Hsü
Research22 May 1980
Nature

Volume: 285, P: 201-203
Wagner Changes, Synartetic Acceleration and Synartetic Ions

F. BROWN
E. D. HUGHES
J. F. SMITH
Research14 Jul 1951
Nature

Volume: 168, P: 65-67
Synthesis of growth hormone by bacteria

P. H. Seeburg
J. Shine
H. M. Goodman
Research01 Dec 1978
Nature

Volume: 276, P: 795-798
Multiple Transverse Breakage of the Filamentous Particles of Turnip Mosaic Virus by Ultrasonic Vibration

J. A. TOMLINSON
D. G. A. WALKEY
D. H. WATSON
Research01 Jul 1965
Nature

Volume: 207, P: 495-497
PEX39 facilitates the peroxisomal import of PTS2-containing proteins

Chen et al. show that PEX39 cooperates with PEX7 in the peroxisomal import of proteins containing a PTS2 site and uncover an (R/K)PWE motif in PEX39 and PEX13 that binds to PEX7 and facilitates the import of PTS2-containing proteins.

Walter W. Chen
Tony A. Rodrigues
Bettina Warscheid
ResearchOpen Access30 Jul 2025
Nature Cell Biology

Volume: 27, P: 1256-1271
Neuronal activity-dependent mechanisms of small cell lung cancer pathogenesis

Glutamatergic and GABAergic (γ-aminobutyric acid-producing) cortical neuronal activity drives proliferation of small lung cell cancer via paracrine interactions and through synapses formed with tumour cells.

Solomiia Savchuk
Kaylee M. Gentry
Humsa S. Venkatesh
ResearchOpen Access10 Sept 2025
Nature

P: 1-11
Binding of Hæmatin by Human Serum Albumin

H. N. LITTLE
J. B. NEILANDS
Research10 Dec 1960
Nature

Volume: 188, P: 913-915
A Correlation Between the Rates of Unimolecular Pyrolysis of Alkyl Halides in the Gaseous Phase and S _NI Rates in Solution

ALLAN MACCOLL
P. J. THOMAS
Research27 Aug 1955
Nature

Volume: 176, P: 392-393
Kinetics and Mechanism of Diazotization

E. D. HUGHES
C. K. INGOLD
J. H. RIDD
Research14 Oct 1950
Nature

Volume: 166, P: 642-643
The cyclin-dependent kinase inhibitor p27^Kip1 safeguards against inflammatory injury

Vuddhidej Ophascharoensuk
Matthew L. Fero
Stuart J. Shankland
Research01 May 1998
Nature Medicine

Volume: 4, P: 575-580
A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3

Claire L. Shovlin
J.M.B. Hughes
J.G. Seidman
Research01 Feb 1994
Nature Genetics

Volume: 6, P: 205-209
Designing small molecules targeting a cryptic RNA binding site through base displacement

This work demonstrates how a biphenyl-like scaffold targets RNA through a common base displacement mechanism by optimizing π-stacking interactions within the binding pocket, helping to inform the design of novel RNA-targeting small molecules.

Lukasz T. Olenginski
Aleksandra J. Wierzba
Robert T. Batey
ResearchOpen Access29 Aug 2025
Nature Chemical Biology

P: 1-10
Demonstration of Super-X divertor exhaust control for transient heat load management in compact fusion reactors

Managing power exhaust in fusion reactors is a key challenge, especially in compact designs for cost-effective commercial energy. This study shows how alternative divertor configurations improve exhaust control, enhance stability, absorb transients and enable independent plasma regulation.

B. Kool
K. Verhaegh
V. Zamkovska
ResearchOpen Access05 Sept 2025
Nature Energy

Volume: 10, P: 1116-1131
Directed evolution-based discovery of ligands for in vivo restimulation of chimeric antigen receptor T cells

An amphiphilic mimotope vaccine can be used in tandem with Food and Drug Administration (FDA)-approved CD19 CAR-T cell products.

Tomasz M. Grzywa
Alexandra Neeser
Darrell J. Irvine
ResearchOpen Access25 Aug 2025
Nature Biomedical Engineering

P: 1-21
Covariation MS uncovers a protein that controls cysteine catabolism

A mass spectrometry-based approach globally identifies protein regulators of metabolism and reveals the role of LRRC58 in controlling cysteine catabolism.

Haopeng Xiao
Martha Ordonez
Edward T. Chouchani
ResearchOpen Access17 Sept 2025
Nature

P: 1-9
Engineering kidney developmental trajectory using culture boundary conditions

Huang et al. show that 3D hydrogel embedding supports more organotypic kidney development in culture. Matrix stiffness and adhesion properties were found to regulate nephron formation, highlighting the intervention potential of physical boundary conditions.

Aria Zheyuan Huang
Louis S. Prahl
Alex J. Hughes
ResearchOpen Access22 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Anaerobic Deamination of D-GLUCOSAMINE by Bacterial and Brain Extracts

P. FAULKNER
J. H. QUASTEL
Research30 Jun 1956
Nature

Volume: 177, P: 1216-1218
Walden Inversion and Reaction Mechanism: Walden Inversion in Unimolecular Reactions of Secondary and Tertiary Alkyl Halides

E. D. HUGHES
C. K. INGOLD
D. F. MEIGH
Research21 Oct 1950
Nature

Volume: 166, P: 679-680
Lubrication of Metal Surfaces by Fatty Acids

F. P. BOWDEN
J. N. GREGORY
D. TABOR
Research28 Jul 1945
Nature

Volume: 156, P: 97-101

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