Nature Search

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for peroxisomes in adipose tissue thermogenesis is identified.

Xuejing Liu
Anyuan He
Irfan J. Lodhi
ResearchOpen Access17 Sept 2025
Nature

P: 1-9
Redefining the treponemal history through pre-Columbian genomes from Brazil

Reconstruction of four Treponema pallidum genomes associated with human remains from around 2,000 years ago suggests that T. pallidum existed in the Americas and diverged to its modern subspecies before the fifteenth century European contact with the Americas.

Kerttu Majander
Marta Pla-Díaz
Verena J. Schuenemann
ResearchOpen Access24 Jan 2024
Nature

Volume: 627, P: 182-188
Gustducin is a taste-cell-specific G protein closely related to the transducins

Susan K. McLaughlin
Peter J. McKinnon
Robert F. Margolskee
Research18 Jun 1992
Nature

Volume: 357, P: 563-569
A cross-population atlas of genetic associations for 220 human phenotypes

Genome-wide analyses in BioBank Japan, UK Biobank and FinnGen identify ~5,000 new loci associated with 220 human traits. Statistical decomposition of matrices of phenome-wide summary statistics further highlights variants underpinning diseases across populations.

Saori Sakaue
Masahiro Kanai
Yukinori Okada
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1415-1424
Genetics of 35 blood and urine biomarkers in the UK Biobank

Genetic analysis of 35 blood and urine laboratory measurements from 363,228 individuals identifies 1,857 loci associated with at least one laboratory value.

Nasa Sinnott-Armstrong
Yosuke Tanigawa
Manuel A. Rivas
Research18 Jan 2021
Nature Genetics

Volume: 53, P: 185-194
Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Human TNF is required for respiratory-burst-dependent immunity to Mycobacterium tuberculosis in macrophages but seems to be largely redundant physiologically.

Andrés A. Arias
Anna-Lena Neehus
Stéphanie Boisson-Dupuis
ResearchOpen Access28 Aug 2024
Nature

Volume: 633, P: 417-425
Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Tom Le Voyer
Audrey V. Parent
Anne Puel
ResearchOpen Access08 Nov 2023
Nature

Volume: 623, P: 803-813
Widespread Amazonian dark earth in the Xingu Indigenous Territory

Past human land modification in the Amazon has resulted in nutrient- and carbon-rich soil deposits of great cultural and environmental value. A new remote-sensing and machine-learning approach reveals the extent of Amazonian dark earth and its potentially substantial carbon reservoir.

Samuel L. Goldberg
Morgan J. Schmidt
J. Taylor Perron
Research26 Jul 2024
Nature Sustainability

Volume: 7, P: 1304-1312
Activity-based directed evolution of a membrane editor in mammalian cells

Cellular membranes contain numerous lipids, and efforts to understand the biological functions of individual lipids demand approaches for controlled modulation of membrane composition in situ. Now, click chemistry-based directed evolution of a microbial phospholipase within mammalian cells affords an editor for optogenetic, targeted modification of phospholipids in cell membranes.

Reika Tei
Saket R. Bagde
Jeremy M. Baskin
Research22 May 2023
Nature Chemistry

Volume: 15, P: 1030-1039
Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Dysregulated immune features in a patient with a homozygous loss-of-function mutation in PDCD1 suggest that IL-6, IL-23, STAT3 and RORγT might be potential targets for treatment of PD-1 blockade-induced autoimmunity.

Masato Ogishi
Rui Yang
Jean-Laurent Casanova
Research28 Jun 2021
Nature Medicine

Volume: 27, P: 1646-1654
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

Protein-truncating variants (PTVs) are predicted to significantly affect a gene’s function and, thus, human traits. Here, DeBoever et al. systematically analyze PTVs in more than 300,000 individuals across 135 phenotypes and identify 27 associations between PTVs and medical conditions.

Christopher DeBoever
Yosuke Tanigawa
Manuel A. Rivas
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-10
Electric control of the spin Hall effect by intervalley transitions

The spin Hall effect plays a central role in generating and manipulating spin currents, but its magnitude is ultimately fixed by spin–orbit coupling effects. It is now shown that the spin-Hall-effect angle can be tuned electrically in GaAs.

N. Okamoto
H. Kurebayashi
C. H. W. Barnes
Research10 Aug 2014
Nature Materials

Volume: 13, P: 932-937
Author Correction: Genetics of 35 blood and urine biomarkers in the UK Biobank

Nasa Sinnott-Armstrong
Yosuke Tanigawa
Manuel A. Rivas
Amendments and Corrections04 Oct 2021
Nature Genetics

Volume: 53, P: 1622
Attosecond spectroscopy reveals alignment dependent core-hole dynamics in the ICl molecule

Here the authors report a study measuring lifetimes of core-hole states of ICl molecule using attosecond transient absorption spectroscopy. They find that lifetimes depend on the alignment of the orbital relative to the molecular axis.

Hugo J. B. Marroux
Ashley P. Fidler
Daniel M. Neumark
ResearchOpen Access16 Nov 2020
Nature Communications

Volume: 11, P: 1-8
Prognostic value of nonangiogenic and angiogenic growth patterns in non-small-cell lung cancer

P Sardari Nia
C Colpaert
P Van Schil
ResearchOpen Access24 Aug 2004
British Journal of Cancer

Volume: 91, P: 1293-1300
Phospholipid methylation regulates muscle metabolic rate through Ca²⁺ transport efficiency

The role of skeletal muscle in non-shivering thermogenesis is not fully elucidated. Here the authors show that, in muscle, phospholipids can influence whole-body metabolic rate and counteract obesity by altering calcium signalling and inducing energy expenditure.

Anthony R. P. Verkerke
Patrick J. Ferrara
Katsuhiko Funai
Research16 Sept 2019
Nature Metabolism

Volume: 1, P: 876-885
Disentangling conical intersection and coherent molecular dynamics in methyl bromide with attosecond transient absorption spectroscopy

Excited-state molecular dynamics may be too complex to be resolved by femtosecond spectroscopic studies. Here the authors resolve the competing pathways in the excited state dynamics of methyl bromide by attosecond transient absorption spectroscopy, from excitation to fragmentation.

Henry Timmers
Xiaolei Zhu
Stephen R. Leone
ResearchOpen Access16 Jul 2019
Nature Communications

Volume: 10, P: 1-8
NAT2 gene diversity and its evolutionary trajectory in the Americas

R Bisso-Machado
V Ramallo
M C Bortolini
Research27 Oct 2015
The Pharmacogenomics Journal

Volume: 16, P: 559-565
nm23-H1 expression defines a high-risk subpopulation of patients with early-stage epithelial ovarian carcinoma

J Schneider
M Pollán
H Meden
ResearchOpen Access21 Apr 2000
British Journal of Cancer

Volume: 82, P: 1662-1670
Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors

Jung-Rok Lee
Noriyuki Sato
Shan X. Wang
ResearchOpen Access05 Jan 2016
Scientific Reports

Volume: 6, P: 1-9
Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

S Thiel
R Steffensen
J C Jensenius
Research25 Jan 2007
Genes & Immunity

Volume: 8, P: 154-163
Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan

T Okusaka
K Nakachi
Y Nimura
ResearchOpen Access13 Jul 2010
British Journal of Cancer

Volume: 103, P: 469-474
The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa

Maud Fléchard
Rachel Duchesne
Sylvie Chevalier
ResearchOpen Access21 Nov 2018
Scientific Reports

Volume: 8, P: 1-13

Search

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

Redefining the treponemal history through pre-Columbian genomes from Brazil

Gustducin is a taste-cell-specific G protein closely related to the transducins

A cross-population atlas of genetic associations for 220 human phenotypes

Genetics of 35 blood and urine biomarkers in the UK Biobank

Tuberculosis in otherwise healthy adults with inherited TNF deficiency

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Widespread Amazonian dark earth in the Xingu Indigenous Territory

Activity-based directed evolution of a membrane editor in mammalian cells

Inherited PD-1 deficiency underlies tuberculosis and autoimmunity in a child

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

Electric control of the spin Hall effect by intervalley transitions

Author Correction: Genetics of 35 blood and urine biomarkers in the UK Biobank

Attosecond spectroscopy reveals alignment dependent core-hole dynamics in the ICl molecule

Prognostic value of nonangiogenic and angiogenic growth patterns in non-small-cell lung cancer

Phospholipid methylation regulates muscle metabolic rate through Ca²⁺ transport efficiency

Disentangling conical intersection and coherent molecular dynamics in methyl bromide with attosecond transient absorption spectroscopy

NAT2 gene diversity and its evolutionary trajectory in the Americas

nm23-H1 expression defines a high-risk subpopulation of patients with early-stage epithelial ovarian carcinoma

Experimental and theoretical investigation of the precise transduction mechanism in giant magnetoresistive biosensors

Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms

Gemcitabine alone or in combination with cisplatin in patients with biliary tract cancer: a comparative multicentre study in Japan

The absence of SigX results in impaired carbon metabolism and membrane fluidity in Pseudomonas aeruginosa

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