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A new platform making use of hexagonal boron nitride interfaced with the molecular superconductor κ-(BEDT-TTF)₂Cu[N(CN)₂]Br is demonstrated for realizing cavity-altered materials, confirmed by magnetic force microscopy and nano-optical measurements.

The authors report a trial subset analysis of the immune responses induced by two inactivated quadrivalent influenza vaccines (QIVs): Sinovac QIV and Vaxigrip-Tetra™. Both vaccines elicit robust humoral responses and distinct T cell profiles.

The temperature-sensitivity of soil dissolved organic carbon (DOC) export is widely debated but limited by the duration of observations. New data from environmental archives supports a pronounced sensitivity between soil DOC leaching and warming.

Harvesting ohmic heat for signal processing is one of major challenges in modern electronics and spin caloritronics, but not yet well accomplished. Here the authors demonstrate a spin torque oscillator device driven by pure spin current arising from thermal gradient across an Y₃Fe₅O₁₂/Pt interface.

Cannabinoid CB₂ receptor (CB₂R) agonists are investigated as therapeutic agents in the clinic. Here, authors report the discovery of LEI-102, a CB₂R agonist, used in conjunction with three other CBR ligands (APD371, HU308, and CP55,940) to investigate selective CB₂R activation.

Cryptic faults concern earthquake scientists, since they pose a hidden seismic potential which is hard to identify. To address this, the authors here study off-fault deformed geomorphic markers such as marine terraces using high-resolution LiDAR topography, optical dating of sediments and space geodetic observations.

Integrating an electronic device with a cavity can cause the electrons to couple to photons strongly enough to form hybrid modes. Now, the cavity effects induced by intrinsic graphite gates are shown to modify the low-energy properties of graphene.

A cross-ancestry meta-analysis of genome-wide association studies identifies association signals for stroke and its subtypes at 89 (61 new) independent loci, reveals putative causal genes, highlighting F11, KLKB1, PROC, GP1BA, LAMC2 and VCAM1 as potential drug targets, and provides cross-ancestry integrative risk prediction.

How quantum many-body systems relax from an initial non-equilibrium state is one of the outstanding problems in quantum statistical physics. A study combining an experimental approach for monitoring the dynamics of strongly correlated cold atoms with theoretical analysis now provides quantitative insights into the problem.

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

This paper explores how voltage-gated potassium channels can plug the pore to prevent the conductance of ions during inactivation.

Magnons are excitations of magnetic materials that can have topological properties similar to those of electrons. Here, the authors show that the magnons of the bulk ferromagnet Mn₅Ge₃ are topological and can be controlled with a magnetic field.

Here, Isaacs, Nieto and Zhang et al. discover a potent nanobody and engineer a dual-action antibody that targets two viral proteins, offering strong protection against Nipah and Hendra viruses while preventing viral escape, potentially contributing to future treatments.

Magnetic stability of holmium atoms on a platinum(111) surface has recently been reported, raising prospects for atomic-scale spintronics, however contradictory results have since emerged. Here, Steinbrecher et al.find evidence for an invisibility of the holmium spin to scanning tunnelling spectroscopy techniques which challenges recent results.

In the Kondo effect, a bath of conduction electrons screens a localized magnetic moment. Here, the authors demonstrate Kondo screening of a normally isolated 4f-like moment in a magnetic molecule on a Cu(001) surface that is modulated by strong ligand-mediated coupling.

Transistors that operate by the passage of electrons through a single-dopant atom achieve the ultimate limit for the miniaturization of electronic devices, but only when multiple transistors are intimately connected can they become useful. Roche et al. demonstrate the equivalent of just this, connecting two such transistors to build a two-atom electron pump.

Heterodyne detectors can measure and analyse high-frequency signals inaccessible to conventional methods. Here the authors analyse heterodyne signal generation and show that, contrary to the common interpretation, both mixing and beating of the target and reference signals are important.

Johannes Krause et al. synthesized seagrass carbon stock data from 2700+ soil cores to find that they vary by plant functional group and coastal setting, indicating where conservation efforts would most effectively avoid emissions from seagrass loss

Over half the world’s rivers dry periodically, yet little is known about the biological communities in dry riverbeds. This study examines biodiversity across 84 non-perennial rivers in 19 countries using DNA metabarcoding. It finds that nutrient availability, climate and biotic interactions influence the biodiversity of these dry environments.

Spin dynamics in magnetic materials can be driven by ultrafast light pulses, resulting in transient magnetization changes on femtosecond timescales. Rudolphet al. find that in magnetic trilayers the magnetization of one layer can be enhanced by superdiffusive spin currents from adjacent layers.

Batlle and colleagues develop an organoid platform for functional antibody screening and identify a therapeutic bispecific antibody that binds EGFR and LGR5 and that shows efficacy across epithelial tumor patient-derived xenograft models in vivo.

There is limited evidence of the effectiveness of the CoronaVac vaccine for children against the Omicron SARS-CoV-2 variant. Here, the authors use data from Brazil for children aged 6–11 years and estimate effectiveness of 40% against infection and 59% against severe disease at least two weeks after the second dose.

The spin–orbit interaction can be used to optically generate and control terahertz electric photocurrents in metallic ferromagnetic heterostructures.

Although Fe doping boosts the electrocatalytic performance of NiOOH materials for the oxygen evolution reaction, the underlying mechanism has been not well understood. Here, the authors reveal Fe low-spin state configuration as a main driver of this electrochemical phenomenon.

In the standard model of particle physics the permanent electric dipole moment of particles is zero, although competing theories suggest it must exist to explain the asymmetry of matter and antimatter in the Universe. The design and synthesis of a new multiferroic material may now enable us to search for the electric dipole moment of electrons with unprecedented precision.

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

The motion of electrons in a complex magnetic background may generate novel magnetic interactions. Here, Grytsiuk et al. report that a peculiar orbital motion of electrons in response to a non-coplanarity of neighbouring spins leads to a topological orbital moment, which further gives rise to a new class of magnetic interactions.

The standard current–phase relation in tunnel Josephson junctions involves a single sinusoidal term, but real junctions are more complicated. The effects of higher Josephson harmonics have now been identified in superconducting qubit devices.

Magnetic energy in the plasma is transferred into particle energy by magnetic reconnection. Here the authors show the two-fluid dynamics of asymmetric magnetic reconnection in two different spatial scales of plasma, namely laboratory and astrophysical plasma.

The authors theoretically propose a simple microscopic mechanism for light-induced superconductivity based on a boson coupled to an electronic interband transition. The electron-electron attraction needed for the superconductivity can be resonantly amplified when the boson’s frequency is close to the energy difference between the two electronic bands. The model can be engineered using a 2D heterostructure.

Phase-change materials show an unusual metal–insulator transition that is induced by disorder in the crystalline state. Numerical computations now show how the transition to the metallic state proceeds from the dissolution of electronic states situated at vacancy clusters to the formation of ordered vacancy layers.

Schneeberger, Kim, Geesdorf, Rajewsky, Heppner et al. tease IL-12 and IL-23 signaling apart in mouse models and human brain tissue to define a role for oligodendroglial and neuronal IL-12 signaling in neuroimmune crosstalk in Alzheimer’s disease.

TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. Using computational electrophysiology simulations, the authors identify the main ion-conductive state of TMEM16 lipid scramblases and find that lipid headgroups modulate ion permeability and regulate ion selectivity of TMEM16 proteolipidic pores.

Electric-field control of magnetization switching is highly promising for low-dissipation spintronics. Here, the authors propose an electrically induced topological phase transition mediated by spin orbit torques as attractive way to control magnetization in absence of longitudinal charge currents.

Probing the molecular dynamics of the membrane motor, prestin, with biophysical measures and MD simulations, Kuwabara et al. find that an elevator-like domain movement across the membrane produces the unique piezoelectric behavior.

Tensor network states efficiently parametrize many-body quantum ground states and entanglement properties of strongly correlated systems. Here, the authors show how the presence of anyons and topological order can be related to symmetry breaking in the virtual boundary theory of the network.

Exsolved metal nanoparticles are widely believed to exhibit an exceptional robustness against coarsening. Here, the authors demonstrate that the coarsening behavior depends on the surface defect chemistry of the respective oxide support as well as the oxophilicity of the exsolved metal.