Recent studies suggest previously unrecognized complications of hyponatremia, including falls, osteoporosis and fractures, and show that hyponatremia can have direct effects on bone, mainly via activation of osteoclasts. Here, the emerging relationship between hyponatremia and bone is reviewed, with special emphasis on possible mechanisms, unanswered questions and clinical implications.
- Ewout J. Hoorn
- George Liamis
- M. Carola Zillikens
