Search

Geochemical data from zircons show that subduction-like processes were operating contemporaneously with stagnant-lid-like processes at different locations as early as 4.4 billion years ago on the Hadean Earth.

Extending their previous findings of brain changes in a first pregnancy, the authors show that a second pregnancy uniquely alters women’s brains, involving both a further fine-tuning of first-pregnancy effects and distinct changes in other networks.

Fluorescence microscopy during CryoFIB milling produces an interferogram that can be used to direct lamella production to labeled structures with accuracy beyond the axial diffraction limit. The approach relies only on real-time feedback from the structure, requiring no image registration.

A covariate-aware analysis reveals that microbiome changes in the gut of patients with chronic kidney disease are better explained by intestinal transit time than by kidney function.

The authors report long-lived pump-induced conductivity suppression in metallic Ti₃C₂ MXenes using ultrafast terahertz and reflectance spectroscopy. The effect is attributed to strong photothermal heating and slow heat dissipation.

Wheat yields in northwest Europe have plateaued since the mid-1990s. This study finds that no ceiling in genetic yield potential has been reached and that climatic conditions have not constrained wheat yields across high-yielding environments in the region thus far; suboptimal agronomic management is responsible for unrealized wheat yield progress of 67–114 kg ha⁻¹ yr⁻¹ during the period 1994–2016.

In statistical physics, systems usually become disordered at high temperatures, but some exhibit entropic order when heated, where one type of ordering enables greater fluctuations in another. Here the authors show how this type of order can persist to arbitrarily high temperature in simple classical and quantum many-body models.

The study of the interplay between topological states and correlated states such as charge density waves (CDW) requires a thorough understanding of their electronic structure. In this work, the authors resolve the fully CDW reconstructed electronic structure of TaTe4, a candidate topological material, using a combined theoretical and experimental approach based on magnetotransport measurements, which also reveal the existence of large magnetic breakdown orbits and linear magnetoresistance.

In this work, researchers show how laser annealing is used to create complex 2D gradients in magnetic properties, which can steer spin waves and domain walls. This fast, maskless method enables the development of next-generation computing devices.

The CMS Collaboration reports the measurement of the spin, parity, and charge conjugation properties of all-charm tetraquarks, exotic fleeting particles formed in proton–proton collisions at the Large Hadron Collider.

Natural hydrogen is generated through chemical and radioactive processes in the Earth’s crust, and could be an important future clean chemical feedstock and energy resource. This Review examines the processes of geological hydrogen generation, migration, accumulation and preservation that enable the development of exploitable reserves.

Ion diffusion region is an indicator of active magnetic reconnection, but it had not been detected in Jupiter’s magnetosphere previously. Here, the authors show a magnetic reconnection event in Jupiter’s inner magnetosphere that presents the detection of an ion diffusion region.

Reliably probing rejuvenation and memory effects in spin glasses by means of simulations is difficult. Now, a state-of-the-art numerical study shows that at least three different length scales play a crucial role in aging dynamics of spin glasses.

A completely solid-state, single-chip, microwave-frequency surface acoustic wave phonon laser can generate coherent phonons from thermal noise or resonantly amplify injected phonons using only a direct current bias field.

Despite high morbidity and mortality, there are currently no approved vaccines for protection against Middle East respiratory syndrome (MERS) coronavirus. Here the authors develop a ferritin nanoparticle-based MERS-CoV vaccine that elicits high levels of neutralizing antibodies in mice, non-human primates, and alpacas and prevents infection in an alpaca challenge model.

Proxy records from Lake Baikal show that rapid cooling coincided with Northern Hemisphere ice sheet expansion 2.7 million years ago, a change accompanied by a transition to open steppe ecosystems.

A cellular neural network that incorporates transistors and multilevel non-volatile memristor synapses can be used for efficient image and video processing.

Taveneau et al. leverage artificial-intelligence-driven protein design to create inhibitors that control RNA-targeting enzymes in cells, revealing a strategy to rapidly design off-switches for RNA-editing systems.

A wide survey of pesticide effects on soil biodiversity across 373 sites in Europe reveals that pesticide residues occur in 70% of sites and have major effects on soil biodiversity and functional ecology.

Excitons dominate the optoelectronic response of many materials and exciton transport often limits the efficiency of optoelectronic devices such as solar cells or photodetectors. Using quantum geometry, the authors find that topological excitons undergo enhanced diffusion across a wide range of transport regimes.

CaBLAM is a bioluminescent genetically encoded calcium indicator that delivers high-contrast signals as shown in cell culture, in the in vivo mouse brain and in zebrafish larvae.

An integrated optical parametric amplifier on thin-film lithium niobate achieves more than 17 dB gain with less than 200 mW input power.

Immunotherapies that employ engineered T cells rely on the selective and high expression of the targeted antigen in cancer cells and thus tumor heterogeneity compromises therapeutic success. Here authors generate an engineered T cell coreceptor that targets a secondary antigen and selectively enhances antigen receptor sensitivity in T cells.

Kinematic measurements of the Perseus galaxy cluster reveal two drivers of gas motions: a small-scale driver in the inner core associated with black-hole feedback and a large-scale driver in the outer core powered by mergers.

A device for rectifying supercurrents at liquid-nitrogen temperature with high efficiency is demonstrated. This is a practical step towards implementing dissipationless electronics.

The STAR experiment at the Relativistic Heavy Ion Collider at Brookhaven National Laboratory demonstrates evidence of spin correlations in \(\Lambda \bar{\Lambda }\) hyperon pairs inherited from virtual spin-correlated strange quark–antiquark pairs during QCD confinement.

Fast panoramic rotational ultrasound tomography and photoacoustic tomography are integrated for hybrid rotational ultrasound and photoacoustic tomography, for three-dimensional dual-contrast imaging of soft tissue and vasculature across the human body.

Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-range chemical signalling.

The authors demonstrate dual-probe multi-messenger imaging of high-energy-density plasmas based on laser-wakefield-accelerated electrons. This enables spatiotemporally resolved simultaneous probing of plasma hydrodynamics and electromagnetic field evolution with both x-ray and electron beams.

Projected impacts of climate change on malaria burden in Africa by 2050 highlight the urgent need for climate-resilient malaria control strategies and robust emergency response systems to safeguard progress towards malaria eradication.

iGluSnFR4f and iGluSnFR4s are the latest generation of genetically encoded glutamate sensors. They are advantageous for detecting rapid dynamics and large population activity, respectively, as demonstrated in a variety of applications in the mouse brain.

The study shows that the spin state of a single titanium atom on an insulating surface can be reversibly switched by its local environment, without chemical changes (no hydrogenation), using advanced microscopy, spectroscopy, and theory.

Spatiotemporal insight into photoactivation of the prototypical B₁₂ photoreceptor CarH is revealed across nine orders of magnitude in time, identifying a transient adduct that distinguishes it from thermally activated B₁₂ enzymes.

Global Burden of Disease estimates show that between 1990 and 2023, the prevalence and burden of drug use disorders, inclusive of amphetamine, cannabis, cocaine and opioid use, have been increasing in high-income countries, particularly in the USA.

The Ocean Equity Index provides a systematic, twelve-criteria framework to assess and improve equity in ocean initiatives, projects and policies, producing structured data that guide evidence-based decisions and support more equitable outcomes for coastal communities and ecosystems.

Central charge, a key quantity in conformal field theories, is crucial in the study of critical phenomena, yet its measurement has remained elusive. Here, the authors extract the central charge of several quantum critical models by accurately preparing their ground states on a superconducting quantum processor.

The authors developed an LXR inverse agonist, TLC-2716, and show it is effective in reducing triglycerides and cholesterol in dysmetabolic preclinical models. Additionally, a phase 1 trial in healthy participants shows that TLC-2716 is well tolerated and reduces plasma triglycerides and postprandial remnant cholesterol, highlighting its potential for managing cardiovascular risk.

A genetic study of natural variation in potato tuberization onset, an important phenotype for breeding potatoes adapted to different global day lengths, has revealed a role for StCDF1, a member of the DOF family of transcription factors.

Chen et al. present EMRAge, a biological age measure built using electronic medical records, and OMICmAge, a multi-omic signal superimposed on DNA methylation. Both measures show strong associations with disease and mortality in validation cohorts.

Using infant fMRI, the authors show that, by 2 months of age, representations in high-level visual cortex encode visual categories that align with deep neural networks, and lateral object-selective regions are later to develop.

NMR is typically carried out in strong magnetic fields, but recent technological developments have enabled the development of different methods for creating and detecting nuclear magnetization that do not depend on the use of strong magnets. A study that combines such methods demonstrates now that high-resolution NMR spectra with chemically relevant information can be obtained at zero magnetic field.

The interplay between competing orders in high-temperature superconductors can be tuned by the application of magnetic fields. Here, Chang et al. report high field induced three-dimensional charge density wave in underdoped YBa₂Cu₃O_6.67, which suggests Fermi surface reconstruction due to competing orders.

A comprehensive atlas platform integrating transcriptional and epigenetic data enables more precise engineering of T cell states, accelerating the rational design of more effective cellular immunotherapies.

Man-made ammonia emissions have harmful effects on human health and ecosystems, yet global mitigation strategies remain underexploited. A study now finds that emissions could be halved cost-effectively by 2050 through targeted and prioritized measures, with benefits far outweighing costs.

This study finds stem-like endothelial cells in the optic nerve that supply and repair retinal blood vessels after injury, revealing a hierarchical repair system that may enable new treatments for blinding vascular eye diseases.

Non-invasive strategies to detect and track activated myeloid cells will facilitate disease diagnosis and monitoring in patients affected by neuroinflammatory disorders. Here, the authors present 18F-FMD, a dendrimer-based PET tracer that detects and monitors activated myeloid cells at different stages (presymptomatic and symptomatic) of Experimental Autoimmune Encephalomyelitis (EAE) in mice and in response to disease-modifying therapies.

A wearable paper-based microfluidic device tracks cortisol in sweat via gold nanoflower colorimetric assays and captures circadian rhythms, stress responses and jet lag disruptions.