Patients with kidney disease are often exposed to high concentrations of iron as a result of the underlying pathological processes. Under these conditions, cellular mechanisms of iron metabolism respond to the changing iron concentrations, which can result in further pathological damage in the kidney. In this Review, the authors discuss mechanisms of iron metabolism under various pathological conditions and the potential role of modulating iron levels as a therapy for progressive kidney diseases.
- A. M. F. Martines
- R. Masereeuw
- D. W. Swinkels
