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The electronic behaviour of complex oxides such as LaNiO₃ depends on many intrinsic and extrinsic factors, making it challenging to identify microscopic mechanisms. Here the authors demonstrate the influence of oxygen vacancies on the thickness-dependent metal-insulator transition of LaNiO₃ films.

This study introduces the Lipid Nanoparticle Database (LNPDB) and web tool that consolidates lipid nanoparticle structure-function data. LNPDB facilitates molecular dynamics and deep learning approaches to advance data-driven design for nucleic acid delivery.

Terahertz microspectroscopic imaging at subgap millielectronvolt energies of a two-dimensional superfluid plasmon in few-layer Bi₂Sr₂CaCu₂O_8+x is demonstrated, allowing the spatial resolution of its deeply subdiffractive terahertz electrodynamics.

The authors demonstrate high-fidelity multi-tone electronic control of trapped-ion qudits up to d=8 levels, enabling efficient SU(d) operations and showcasing advantage by implementing Grover’s search algorithm using encoding in a single qudit, rather than in multiple qubits.

Anderson et al. demonstrate that the glucokinase activator AZD1656 reduces inflammation and reverses cardiac dysfunction and metabolic remodeling in mice with diabetic cardiomyopathy.

KRAS is an oncogene that switches between a GDP-bound inactive state and a GTP-bound active state. Recently developed KRAS G12C inhibitors are specific to the GDP-bound inactive state. Here, the authors develop a class of covalent KRAS G12C inhibitors capable of targeting both states for the treatment of KRAS-driven cancer.

The transcription factor ATF4 and its effector lipocalin 2 (LCN2) have a key role in immune evasion and tumour progression, and targeting the ATF4–LCN2 axis might provide a way to treat several types of solid tumour by increasing anti-cancer immunity.

An algorithm that combines deep learning, Bayesian optimization and computer vision techniques can be used to autonomously tune a semiconductor spin qubit from a grounded device to Rabi oscillations.

It is unclear whether the harsh abiotic conditions of drylands hinder biological invasions. This global analysis shows that drylands are vulnerable to non-native plants and are likely to become more so as native plant diversity declines and grazing pressure intensifies.

A skeleton of the alvarezsauroid Alnashetri cerropoliciensis—representing a highly complete alvarezsauroid skeleton from South America—provides evidence on the evolution of the peculiar anatomy and miniaturization within this unusual theropod dinosaur clade.

Authors study links between amyloid secondary nucleation and growth defects, demonstrating these sites on Aβ40/Aβ42 fibrils are rare compared to the number of protein molecules. Re-analysis of published data suggests that defects may also drive secondary nucleation generally.

Evolutionarily related ‘proto-point’ centromeres providing resolution to the evolutionary origins of point centromeres are identified in yeast, and comparison shows they evolved in an ancestor with retrotransposon-rich centromeres and that long-terminal-repeat retrotransposons are the genetic substrate.

Diastereoselective hydrogenation of multi-substituted (hetero)arenes provides an efficient and industrially valuable route for transforming these compounds into diversified 3D building blocks, with broad applications such as drug discovery. Here, the authors demonstrate that a rationally designed Pt catalyst enables general diastereoselective hydrogenation of a wide variety of multi-substituted and functionalized arenes and heteroarenes under mild conditions.

From 2014–2017, marine heatwaves caused global mass coral bleaching, where the corals lose their symbiotic algae. The authors find, this event exceeded the severity of all prior global bleaching events in recorded history, with approximately half the world’s reefs bleaching and 15% experiencing substantial mortality.

The vacuum process is scalable and solvent free, yet all-vacuum-deposited perovskite solar cells still trail solution-processed counterparts. Facet-directed co-evaporation yields (100)-oriented mixed-halide wide-bandgap films for efficient, stable single-junction cells and perovskite–silicon tandem cells.

This study of magic-angle twisted trilayer graphene moiré superconductors using scanning tunnelling microscopy and spectroscopy identifies two energy gaps that develop from many-body resonance in this highly tunable class of materials.

Plasmas can unlock unconventional reactivity for established catalytic systems, but understanding the resulting mechanistic changes is a complex endeavour. Here in situ characterization techniques allow us to rationalize the promotional role of non-thermal plasma on the catalytic hydrogenation of CO₂ to methanol on Cu–Zn systems.

Two main acceleration mechanisms in the auroral acceleration region are electric potential and Alfvénic acceleration but associated energy dynamics are not completely resolved. Here, the authors show that Alfvén waves power the Earth’s auroral arc through a static potential drop in the auroral acceleration region.

In one-shot perceptual learning, what we see can be dramatically altered by a single past experience. Using psychophysics, fMRI, iEEG, and DNNs, the authors identify neural and computational mechanisms underlying this remarkable ability in humans.

Rare coding variants that reduce the activity of a protein can have a beneficial impact on health. Here, researchers identify rare genetic variants in the CHRNB3 gene that associate with reduced cigarette smoking across diverse populations.

A human spinal cord organoid model can replicate two different types of spinal cord injury and can be used as an in vitro system to evaluate therapeutics and inflammatory reactions to treatments.

The severity of climate change impacts calls for low-carbon thermal management solutions. This work presents a chameleon-inspired electronic skin for adaptive electrochromic thermal regulation with minimal energy input and scalability potential.

The authors conduct a national inventory on individual tree carbon stocks in Rwanda using aerial imagery and deep learning. Most mapped trees are located in farmlands; new methods allow partitioning to any landscape categories, effective planning and optimization of carbon sequestration and the economic benefits of trees.

Taking advantage of the abundant renewable energy sources along seashores, this work describes a three-chamber electrolyser that combines electrolysis and desalination to produce both freshwater and green hydrogen.

Resonant inelastic X-ray scattering interferometry reveals a highly entangled electronic phase in Nd₂Ir₂O₇, enabling extraction of its entanglement structure and confirming the cubic-symmetry-breaking order predicted from complementary Raman spectroscopy.

Instabilities in chiral plasmas can amplify electromagnetic waves, raising the question of whether chiral solids behave similarly. Now a magneto-chiral instability is demonstrated in tellurium, observed as growing terahertz emission after photoexcitation.

Using phylogenetic comparative methods across 237 species from disparate phyla, the authors show that species with fast-paced ecologies have higher temporal resolution of perception.

Three-dimensional chiral magnetic tubes created via two-photon lithography and nickel film deposition exhibit chiral spin textures and non-reciprocal magnon transport.

The authors realize two- and three-site Kitaev chains in semiconducting quantum dots coupled via superconductors and tune them to the sweet spot where zero-energy Majorana modes appear at the chain ends. To assess Majorana localization, they couple the system to an additional quantum dot.

This study reveals high-spin state formation and quintet-mediated emission in diphenylhexatriene oligomers. Quintet states dominate delayed fluorescence up to room temperature, establishing a spin-selective platform for quantum technologies.

The authors create a room-temperature super relaxor critical state in a lead-free ceramic, delivering dual-high recoverable energy density and efficiency by residing at a crossover between dynamic and static/frozen polar states.

The properties of electronic transport through edge states of three-dimensional quantum Hall-like states are not yet resolved. Now, increasing the surface area of the edges is shown to produce increased conductance, suggesting that chiral surface states are present.

Dynein–dynactin–cargo adaptor complexes typically function with two dynein motors. Rao et al. show that, under mechanical load, these complexes can recruit a third dynein via a second adaptor, increasing force generation.

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of biological systems.

NiPS₃ is a van der Waals antiferromagnetic semiconductor where the exciton formation is strongly influenced by the magnetic ordering. Previous studies have been limited to magneto-optical approaches, but here, Lebedev, Gish and coauthors succeed in making field effect transistors that operate below the Néel temperature and observe an ultranarrow electroluminescence with a high degree of linear polarization.

Astrocytes in the basolateral amygdala dynamically track fear state and support fear memory retrieval and extinction.

Virtual nature exposure reduces self-reported pain and is associated with decreased brain responses linked to somatosensory and nociceptive processing, providing new insights into the underlying mechanisms of nature-induced analgesia.

Here the authors compare genetic testing strategies in rare movement disorders, improve diagnostic yield with genome analysis, and establish CD99L2 as an X-linked spastic ataxia gene, showing that CD99L2–CAPN1 signaling disruption likely drives neurodegeneration.

Three-component Fermi gases represent a versatile platform for quantum simulation, including quantum chromodynamics-like physics, pairing and few-body effects. Here the authors demonstrate control of spin imbalances and an unexpected asymmetric decay due to different three-body losses for each component, and whose microscopic mechanism remains to be understood.

Mucosal administration of a multivalent, adjuvanted vaccine against Clostridioides difficile promoted bacterial clearance and protected against morbidity, mortality, tissue damage and recurrence in mice.

Frustrated quantum magnets have been studied intensely, owing to their potential of hosting exotic quantum magnetism, however, experimental realisation of model systems, such as the spin-1/2 Heisenberg antiferromagnet on an anisotropic triangular lattice is challenging. Here Gen et al demonstrate that the rhenium oxyhalides, A3ReO5X2, though chemical substitution can span a diverse effective spin Hamiltonians.

Nechanitzky et al. examine the cell-intrinsic role of choline acetyltransferase (ChAT)-expressing B cells in germinal center immune responses.

The deep learning model STARLING can generate accurate ensembles of intrinsically disordered regions of proteins using only protein sequence as input.