Nature Search

Supercoiled DNA recognition and cleavage control in topoisomerase VI

DNA recognition and cleavage control in type II topoisomerases are poorly understood processes. Here, the authors determine cleaved and uncleaved structures of supercoiled DNA-bound topoisomerase VI that reveal how the enzyme activates its cleavage state and prefers to act at deformable substrates.

Daniel E. Richman
Timothy J. Wendorff
James M. Berger
ResearchOpen Access16 Feb 2026
Nature Communications

P: 1-15
Genetic modifiers of APOE-ε4-associated cognitive decline

The APOE-ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease, but it is not deterministic. Here, the authors show that common genetic variation changes how APOE-ε4 influences cognition.

Alex G. Contreras
Skylar Walters
Timothy J. Hohman
ResearchOpen Access20 Feb 2026
Nature Communications

P: 1-17
Higher stability of novel live-attenuated oral poliovirus type 2 (nOPV2) despite the emergence of a neurovirulent double recombinant strain in Uganda

Whole-genome sequencing of polioviruses in Uganda following nOPV2 use showed high genetic stability and no sustained transmission, even though a rare double recombinant strain regained virulence, but did not spread due to high vaccination coverage.

Phionah Tushabe
Manasi Majumdar
Josephine Bwogi
ResearchOpen Access19 Jan 2026
Nature Microbiology

Volume: 11, P: 406-414
Light converts endosymbiotic fungus to pathogen, influencing seedling survival and host tree recruitment

Patricia Alvarez
James White Jr
Thea Kristiansen
ResearchOpen Access23 May 2008
Nature Precedings

P: 1
A benchmark of expert-level academic questions to assess AI capabilities

Humanity’s Last Exam, a multi-modal benchmark at the frontier of human knowledge, is designed to be an expert-level closed-ended academic benchmark with broad subject coverage.

Long Phan
Alice Gatti
Davide Scaramuzza
ResearchOpen Access28 Jan 2026
Nature

Volume: 649, P: 1139-1146
Diamagnetic Susceptibility of Heavy Water

V. C. G. TREW
JAMES F. SPENCER
Research25 Apr 1936
Nature

Volume: 137, P: 706
Character displacement of Cercopithecini primate visual signals

Visual signals that help individuals recognize their own species are predicted to be distinct from those of closely related sympatric species, but evidence for this pattern is scarce. Here, Allen et al.show guenon faces are distinctive, specifically from those of other guenon species they encounter.

William L. Allen
Martin Stevens
James P. Higham
Research26 Jun 2014
Nature Communications

Volume: 5, P: 1-10
Quantitative Studies with Antilymphocytic Antibody

M. F. A. WOODRUFF
B. L. REID
K. JAMES
Research25 Nov 1967
Nature

Volume: 216, P: 758-762
De novo variants in the splicing factor gene SF3B1 are associated with neurodevelopmental disorders

This study reports that de novo germline missense variants in SF3B1, distinct from the somatic variants frequently observed in cancer, cause a neurodevelopmental disorder and disrupt global RNA splicing.

Kevin Uguen
Tiffany Bergot
Delphine G. Bernard
ResearchOpen Access23 Jan 2026
Nature Communications

Volume: 17, P: 1-17
TDP-43 loss induces cryptic polyadenylation in ALS/FTD

The authors find that TDP-43 loss of function—the pathology defining the neurodegenerative conditions ALS and FTD—induces novel mRNA polyadenylation events, which have different effects, including an increase in RNA stability, leading to higher protein levels.

Sam Bryce-Smith
Anna-Leigh Brown
Pietro Fratta
ResearchOpen Access21 Oct 2025
Nature Neuroscience

Volume: 28, P: 2190-2200
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Structure of a human common cold virus and functional relationship to other picornaviruses

Michael G. Rossmann
Edward Arnold
Gerrit Vriend
Research12 Sept 1985
Nature

Volume: 317, P: 145-153
Whole-genome sequencing reveals host factors underlying critical COVID-19

Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

Athanasios Kousathanas
Erola Pairo-Castineira
J. Kenneth Baillie
ResearchOpen Access07 Mar 2022
Nature

Volume: 607, P: 97-103
Detection of an Interstellar Flux of Gamma-Rays

ALBERT E. METZGER
ERNEST C. ANDERSON
JAMES R. ARNOLD
Research21 Nov 1964
Nature

Volume: 204, P: 766-767
Genome-wide analyses identify 30 loci associated with obsessive–compulsive disorder

Genome-wide analyses identify 30 independent loci associated with obsessive–compulsive disorder, highlighting genetic overlap with other psychiatric disorders and implicating putative effector genes and cell types contributing to its etiology.

Nora I. Strom
Zachary F. Gerring
Manuel Mattheisen
ResearchOpen Access13 May 2025
Nature Genetics

Volume: 57, P: 1389-1401
Observing character displacement from process to pattern in a novel vertebrate community

When similar species coexist, they often evolve differences to reduce competition, a process called character displacement. This study provides rare evidence of character displacement in action, showing how natural selection drives rapid trait changes in lizards when a new competitor arrives.

James T. Stroud
Sean T. Giery
Jonathan B. Losos
ResearchOpen Access14 Nov 2024
Nature Communications

Volume: 15, P: 1-10
Cyclic Nucleotides as Intracellular Mediators of the Expression of Antigen-sensitive Cells

JAMES WATSON
RUTH EPSTEIN
MELVIN COHN
Research14 Dec 1973
Nature

Volume: 246, P: 405-409
Aquatic sources and sinks for nitrous oxide

James W. Elkins
Steven C. Wofsy
Warren A. Kaplan
Research19 Oct 1978
Nature

Volume: 275, P: 602-606
Transfer Effects of Intraperitoneal Injection of Brain Homogenates

JAMES A. DYAL
ARNOLD M. GOLUB
ROBERT L. MARRONE
Research13 May 1967
Nature

Volume: 214, P: 720-721
A Proton Magnetic Resonance Study of the Hydration of Deoxyribonucleic Acid

BERTIL JACOBSON
WESTON A. ANDERSON
JAMES T. ARNOLD
Research24 Apr 1954
Nature

Volume: 173, P: 772-773
Soliton formation and cis trans isomerization in polyacetylene

James C. W. Chien
Frank E. Karasz
Gary E. Wnek
Research05 Jun 1980
Nature

Volume: 285, P: 390-392
Solute and Water Absorption by the Human Small Intestine

HAROLD P. SCHEDL
JAMES A. CLIFTON
Research28 Sept 1963
Nature

Volume: 199, P: 1264-1267
The gene for achondroplasia maps to the telomeric region of chromosome 4p

Milen Velinov
Susan A. Slaugenhaupt
Petros Tsipouras
Research01 Mar 1994
Nature Genetics

Volume: 6, P: 314-317
Production of hydrogen and carbon nanotubes from methane using a multi-pass floating catalyst chemical vapour deposition reactor with process gas recycling

Methane pyrolysis produces hydrogen and carbon materials, but some approaches based on chemical vapour deposition actually consume hydrogen to mitigate unwanted side reactions. Here Peden et al. use gas recycling in a multi-pass floating catalyst chemical vapour deposition reactor to produce hydrogen alongside carbon nanotube aerogels.

Jack Peden
James Ryley
Adam Boies
ResearchOpen Access01 Dec 2025
Nature Energy

Volume: 11, P: 121-134
Growth rate influence on the chemical composition of phytoplankton in oceanic waters

Joel C. Goldman
James J. McCarthy
Dwight G. Peavey
Research17 May 1979
Nature

Volume: 279, P: 210-215
Dynamic fibroblast–immune interactions shape recovery after brain injury

Spatial transcriptomic studies and lineage tracing reveal that, after brain injury, transient profibrotic fibroblasts develop from existing brain fibroblasts, infiltrate lesions, regulate the local immune response and lead to beneficial scar tissue formation.

Nathan A. Ewing-Crystal
Nicholas M. Mroz
Ari B. Molofsky
ResearchOpen Access03 Sept 2025
Nature

Volume: 646, P: 934-944
Structural basis of deoxynucleotide addition by HIV-1 RT during reverse transcription

The intermediate states occurring during nucleotide addition by HIV-1 RT remain unclear. Here, authors use cryo-EM to capture five unique states that show how a mobile catalytic Mg²⁺ drives phosphodiester bond formation.

Sandra Vergara
Xiaohong Zhou
Guillermo Calero
ResearchOpen Access04 Dec 2024
Nature Communications

Volume: 15, P: 1-14
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Complete DNA sequence of yeast chromosome XI

B. Dujon
D. Alexandraki
H. W. Mewes
Research02 Jun 1994
Nature

Volume: 369, P: 371-378
Antagonism by Aspirin and Fenamates of Bronchoconstriction and Nociception induced by Adenosine-5′-triphosphate

H. O. J. COLLIER
G. W. L. JAMES
C. SCHNEIDER
Research22 Oct 1966
Nature

Volume: 212, P: 411-412
Crystal structure of an RNA bacteriophage coat protein–operator complex

Karin Valegård
James B. Murray
Lars Liljas
Research13 Oct 1994
Nature

Volume: 371, P: 623-626
Effect of an RNA-rich Extract on Acquisition of a One-way Avoidance Response in Rats

DAVID H. MALIN
ARNOLD M. GOLUB
JAMES V. MCCONNELL
Research17 Sept 1971
Nature

Volume: 233, P: 211-212
Apolipoprotein E ε4 allele is associated with deposition of amyloid β-protein following head injury

James A.R. Nicoll
Gareth W. Roberts
David I. Graham
Research01 Feb 1995
Nature Medicine

Volume: 1, P: 135-137
Repeated Freeze–Thaw Cycles in Cryosurgery

WILLIAM GILL
JAMES FRASER
DAVID C. CARTER
Research01 Jul 1968
Nature

Volume: 219, P: 410-413
Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors

Cellular state cooccurrence signatures, such as carcinoma ecotypes may serve as potential biomarkers of response to cancer immunotherapy, however, their clinical utility remains unexplored. Here, the authors analyse large real world immunotherapy cohorts and gene expression data and develop a predictive model for response.

Xuefeng Wang
Tingyi Li
Ahmad A. Tarhini
ResearchOpen Access13 Nov 2025
Nature Communications

Volume: 16, P: 1-13
Enhancing nanoscale charged colloid crystallization near a metastable liquid binodal

Controlling nanoscale colloidal crystallization is not straightforward. Such control is now achieved by leveraging a metastable liquid phase of charged nanocrystals.

Christian P. N. Tanner
Vivian R. K. Wall
Naomi S. Ginsberg
Research26 Aug 2025
Nature Physics

Volume: 21, P: 1594-1602
Sex Differences in Human Skeletal Involution

MURRAY H. BARTLEY JUN.
JAMES S. ARNOLD
Research27 May 1967
Nature

Volume: 214, P: 908-909
Proteasome subunits encoded in the MHC are not generally required for the processing of peptides bound by MHC class I molecules

Daniele Arnold
James Driscoll
Thomas Spies
Research12 Nov 1992
Nature

Volume: 360, P: 171-174
Structure of the adenylyl cyclase catalytic core

Gongyi Zhang
Yu Liu
James H. Hurley
Research20 Mar 1997
Nature

Volume: 386, P: 247-253
Personalized ML-based wearable robot control improves impaired arm function

Portable robots may assist subjects with disabilities. However, upper limb movements are hard to fine-tune. Here, the authors design a personalized AI intention detection model to decode user’s motion intention from IMU and compression sensors.

James Arnold
Prabhat Pathak
Conor J. Walsh
ResearchOpen Access02 Aug 2025
Nature Communications

Volume: 16, P: 1-14
Lunar studies

James R. Arnold
Books & Arts01 Dec 1977
Nature

Volume: 270, P: 763-764
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

Xinruo Zhang
Jennifer A. Brody
Anne E. Justice
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Defective myosin VIIA gene responsible for Usher syndrome type IB

Dominique Well
Stéphane Blanchard
Christine Petit
Research02 Mar 1995
Nature

Volume: 374, P: 60-61
Inorganic carbon uptake in hydrothermal vent tubeworms facilitated by high environmental pC0₂

James J. Childress
Raymond W. Lee
James Brooks
Research11 Mar 1993
Nature

Volume: 362, P: 147-149
Symbiosis of methylotrophic bacteria and deep-sea mussels

Colleen M. Cavanaugh
Piet R. Levering
Mary E. Lidstrom
Research22 Jan 1987
Nature

Volume: 325, P: 346-348
Electron Microscopic Appearance of Close Relationships between Adult Guinea Pig Fibroblasts in Tissue Culture

ROSEMARY DEVIS
D. W. JAMES
Research19 May 1962
Nature

Volume: 194, P: 695-696
Expression of marine H–2K^b histocompatibility antigen in cells transformed with cloned H–2 genes

A. L. Mellor
L. Golden
R. A. Flavell
Research05 Aug 1982
Nature

Volume: 298, P: 529-534
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Bridging two insect flight modes in evolution, physiology and robophysics

Asynchronous flight in all major groups of insects likely arose from a single common ancestor with reversions to a synchronous flight mode enabled by shifts back and forth between different regimes in the same set of dynamic parameters.

Jeff Gau
James Lynch
Simon Sponberg
ResearchOpen Access04 Oct 2023
Nature

Volume: 622, P: 767-774

Search

Filter By:

Search

Quick links