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Showing 301–350 of 485 results

Advanced filters: Author: JOHN O'CONNOR Clear advanced filters

COSTS OF EDUCATING CHILD HFALTH ASSOCIATES

John E Ott
George K Knox
Henry K Sliver
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 380
The Effect of a Practice Guideline on Day of Neonatal Discharge 1157

Suzanne M Touch
Frank W Bowen
David B Nash
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 198
Variations In The Day of The Week Discharge: An example of Unwarranted Variation? 1350

Suzanne M Touch
Michael S Kornhauser
David B Nash
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 231
Do Regional Differences in Neonatal Critical Care Effect Length of Stay? 548

Suzanne M Touch
Michael S Kornhauser
David B Nash
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 96
Evidence of cis-acting factors in replication-mediated trinucleotide repeat instability in primate cells

John D. Cleary
Kerrie Nichol
Christopher E. Pearson
Research22 Apr 2002
Nature Genetics

Volume: 31, P: 37-46
The coming global economic downturn and suicide: a call to action

Mark Sinyor
Keith Hawton
Thomas Niederkrotenthaler
Correspondence18 Apr 2023
Nature Mental Health

Volume: 1, P: 233-235
Genital microbiota of women using a 90 day tenofovir or tenofovir and levonorgestrel intravaginal ring in a placebo controlled randomized safety trial in Kenya

Smritee Dabee
Nelly Mugo
Deborah Donnell
ResearchOpen Access14 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
A multisubstrate reductase from Plantago major: structure-function in the short chain reductase superfamily

Rachel Fellows
Christopher M. Russo
Max H. Nanao
ResearchOpen Access04 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Geographical limits to species-range shifts are suggested by climate velocity

Global maps constructed using climate-change velocities to derive spatial trajectories for climatic niches between 1960 and 2100 show past and future shifts in ecological climate niches; properties of these trajectories are used to infer changes in species distributions, and thus identify areas that will act as climate sources and sinks, and geographical barriers to species migrations.

Michael T. Burrows
David S. Schoeman
Elvira S. Poloczanska
Research09 Feb 2014
Nature

Volume: 507, P: 492-495
Global imprint of climate change on marine life

Research that combines all available studies of biological responses to regional and global climate change shows that 81–83% of all observations were consistent with the expected impacts of climate change. These findings were replicated across taxa and oceanic basins.

Elvira S. Poloczanska
Christopher J. Brown
Anthony J. Richardson
Research04 Aug 2013
Nature Climate Change

Volume: 3, P: 919-925
AN EXPLANATION FOR THE HETEROGENEITY IN B LYMPHOCYTE ECTO-5′-NUCLEOTIDASE (ECT0–5′-NT) ACTIVITY IN PATIENTS WITH HYPOGAMMAGLOBULINEMIA: 208

Linda F Thompson
Richard P O'connor
John F Bastian
Research01 Jul 1985
Pediatric Research

Volume: 19, P: 778
Author Correction: Clonal haematopoiesis and risk of chronic liver disease

Waihay J. Wong
Connor Emdin
Pradeep Natarajan
Amendments and Corrections03 Jul 2023
Nature

Volume: 619, P: E47
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
The Syndrome of Congenital Adrenocortical Unresponsiveness to ACTH. Report of Six Cases

Claude J Migeon
Frederic M Kenny
Robert M Blizzard
Research01 Nov 1968
Pediatric Research

Volume: 2, P: 501-513
Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families

Lyle J Palmer
Paul R Burton
William OCM Cookson
Research31 Oct 2000
European Journal of Human Genetics

Volume: 8, P: 853-860
The Effect of Chemical Sympathectomy on Catecholamine Release at Birth

Youtaro Agata
James F Padbury
James A Humme
Research01 Dec 1986
Pediatric Research

Volume: 20, P: 1338-1344
Great ape genetic diversity and population history

High-coverage sequencing of 79 (wild and captive) individuals representing all six non-human great ape species has identified over 88 million single nucleotide polymorphisms providing insight into ape genetic variation and evolutionary history and enabling comparison with human genetic diversity.

Javier Prado-Martinez
Peter H. Sudmant
Tomas Marques-Bonet
ResearchOpen Access03 Jul 2013
Nature

Volume: 499, P: 471-475
Low Plasma GABA Is a Trait-Like Marker for Bipolar Illness

Frederick Petty
Gerald L. Kramer
A. John Rush
Research01 Sept 1993
Neuropsychopharmacology

Volume: 9, P: 125-132
Inhaled Nitric Oxide Improves Gas Exchange and Lowers Pulmonary Vascular Resistance in Severe Experimental Hyaline Membrane Disease

John P Kinsella
D Dunbar Ivy
Steven H Abman
Research01 Sept 1994
Pediatric Research

Volume: 36, P: 402-408
Estimation of environmental tobacco smoke exposure during pregnancy using a single question on household smokers versus serum cotinine

FARLA LYNN KAUFMAN
MARTIN KHARRAZI
JOHN THOMAS BERNERT
Research28 Jun 2002
Journal of Exposure Science & Environmental Epidemiology

Volume: 12, P: 286-295
Raising the BAR of specificity

Phosphinothricin resistance is a widely used trait in plant science research and agriculture. The BAR resistance gene that inactivates phosphinothricin has now been shown to produce two non-specific metabolites in planta. An engineered BAR resistance gene with no detectable off-target activity is developed to address this issue.

Sarah E. O’Connor
News & Views27 Nov 2017
Nature Plants

Volume: 3, P: 924-925
Structural determinants of reductive terpene cyclization in iridoid biosynthesis

The biosynthesis of iridoids, a class of bicyclic monoterpenes, features an atypical cyclization reaction catalyzed by iridoid synthase (ISY). Crystallographic and biochemical characterization of ISY from Catharanthus roseus provides insights into the ISY enzymatic mechanism and highlights similarities with the homologous progesterone 5β-reductase.

Hajo Kries
Lorenzo Caputi
Sarah E O'Connor
Research09 Nov 2015
Nature Chemical Biology

Volume: 12, P: 6-8
A cautionary perspective regarding the isolation and serial propagation of SARS-CoV-2 in Vero cells

Simon G. P. Funnell
Babak Afrough
Ivana Knezevic
ResearchOpen Access17 Jun 2021
npj Vaccines

Volume: 6, P: 1-5
The case for altruism in institutional diagnostic testing

Ivan Specht
Kian Sani
Pardis C. Sabeti
ResearchOpen Access03 Feb 2022
Scientific Reports

Volume: 12, P: 1-7
Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids

Structural and mutational analysis of three homologous cyclases involved in the biosynthesis of iboga and aspidosperma alkaloids reveals how they convert a common substrate into three distinct scaffolds by controlling regio- and stereoselectivity.

Lorenzo Caputi
Jakob Franke
Sarah E. O’Connor
Research17 Feb 2020
Nature Chemical Biology

Volume: 16, P: 383-386
The state-of-the-art of N-of-1 therapies and the IRDiRC N-of-1 development roadmap

A very small number of people with rare diseases caused by unique genetic variants have been treated with therapies developed specifically for them, known as N-of-1 therapies. This Review discusses advances and challenges for N-of-1 therapies based on cases in which they have been successfully developed, highlights why the traditional drug development and reimbursement pathway is not fit for purpose in this field, and provides a roadmap for the development of these individualized therapies.

Anneliene H. Jonker
Elena-Alexandra Tataru
Annemieke Aartsma-Rus
Reviews04 Nov 2024
Nature Reviews Drug Discovery

Volume: 24, P: 40-56
Identification of unique neoantigen qualities in long-term survivors of pancreatic cancer

The analysis of T-cell antigens in long-term survivors of pancreatic ductal adenocarcinoma suggests that neoantigen immunogenicity and quality, not purely quantity, correlate with survival.

Vinod P. Balachandran
Marta Łuksza
Steven D. Leach
Research01 Nov 2017
Nature

Volume: 551, P: 512-516
Mathematics off the main line

John O'Connor
Books & Arts10 Oct 2002
Nature

Volume: 419, P: 563
Author Correction: Genomic analysis of sewage from 101 countries reveals global landscape of antimicrobial resistance

Patrick Munk
Christian Brinch
Frank M. Aarestrup
Amendments and CorrectionsOpen Access12 Jan 2023
Nature Communications

Volume: 14, P: 1
Selectable Marker Genes Engineered for Specific Expression in Target Cells for Plant Transformation

Sebahattin Özcan
Simon Firek
John Draper
Research01 Feb 1993
Bio/Technology

Volume: 11, P: 218-221
Genome-wide germline correlates of the epigenetic landscape of prostate cancer

Genetic variants in the germ line modulate DNA methylation in tumors and contribute to the aggressiveness of prostate cancer.

Kathleen E. Houlahan
Yu-Jia Shiah
Paul C. Boutros
Research07 Oct 2019
Nature Medicine

Volume: 25, P: 1615-1626
Inaccuracies of deterministic finite-element models of human middle ear revealed by stochastic modelling

Arash Ebrahimian
Hossein Mohammadi
Nima Maftoon
ResearchOpen Access05 May 2023
Scientific Reports

Volume: 13, P: 1-13
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4

Terri Beaty and colleagues report a genome-wide association study of cleft lip with/without cleft palate. They identified variants near MAFB and ABCA4 associated with risk of this birth defect in case-parent trios of European and Asian ancestry.

Terri H Beaty
Jeffrey C Murray
Alan F Scott
Research02 May 2010
Nature Genetics

Volume: 42, P: 525-529
A multiscalar methodology for holistic analysis of prehistoric rock carvings in Scotland

Tertia Barnett
Joana Valdez-Tullett
Guillaume Robin
ResearchOpen Access12 Mar 2024
Heritage Science

Volume: 12, P: 1-35
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

Michael Cho and colleagues report a genome-wide association study of risk for chronic obstructive pulmonary disease (COPD) in a large, multi-ancestry cohort. They identify 22 genome-wide significant loci, including 13 not previously associated with COPD and 4 not previously associated with any lung function trait.

Brian D Hobbs
Kim de Jong
Michael H Cho
Research06 Feb 2017
Nature Genetics

Volume: 49, P: 426-432
AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation

A regulatory mechanism that limits the number of complete protein molecules that can be synthesized from a single mRNA molecule of the human AMD1 gene encoding adenosylmethionine decarboxylase 1.

Martina M. Yordanova
Gary Loughran
Pavel V. Baranov
Research03 Jan 2018
Nature

Volume: 553, P: 356-360
Csa-19, a radiation-responsive human gene, identified by an unbiased two-gel cDNA library screening method in human cancer cells

Elizabeth K Balcer-Kubiczek
Stephen J Meltzer
John M Abraham
Research26 Jun 1997
Oncogene

Volume: 14, P: 3051-3057
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase

AV Patterson
H Zhang
AL Harris
Research01 Sept 1995
British Journal of Cancer

Volume: 72, P: 669-675
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

An in vivo transposon screen in a pancreatic cancer model identifies frequent inactivation of Usp9x; deletion of Usp9x cooperates with Kras^G12D to accelerate rapidly pancreatic tumorigenesis in mice, validating their genetic interaction.

Pedro A. Pérez-Mancera
Alistair G. Rust
David A. Tuveson
Research29 Apr 2012
Nature

Volume: 486, P: 266-270
Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility

Margaret Wrensch and colleagues report a genome-wide association and replication study for high-grade glioma. They show that common variants in the CDKN2B and RTEL1 regions are associated with risk of this aggressive brain tumor.

Margaret Wrensch
Robert B Jenkins
John K Wiencke
Research05 Jul 2009
Nature Genetics

Volume: 41, P: 905-908
Author Correction: Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

Sanjay Jain
Liming Pei
Michael P. Snyder
Amendments and Corrections01 Mar 2024
Nature Cell Biology

Volume: 26, P: 839
Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

A neuronal model of bipolar disorder based on induced pluripotent stem cell (iPSC) technology finds hyperactive action-potential firing and differential responsiveness to lithium in iPSC-derived neurons from patients with bipolar disorder.

Jerome Mertens
Qiu-Wen Wang
Jun Yao
Research28 Oct 2015
Nature

Volume: 527, P: 95-99
Remarkable muscles, remarkable locomotion in desert-dwelling wildebeest

Wildebeest, particularly during their long migrations under hot arid conditions, gain a considerable increase in range as a result of having highly efficient muscles.

Nancy A. Curtin
Hattie L. A. Bartlam-Brooks
Alan M. Wilson
Research24 Oct 2018
Nature

Volume: 563, P: 393-396
Author Correction: A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response

Yang Luo
Masahiro Kanai
Soumya Raychaudhuri
Amendments and Corrections02 Nov 2021
Nature Genetics

Volume: 53, P: 1722
The effect of pupil dilation with tropicamide on vision and driving simulator performance

Theo Potamitis
Sarah V Slade
Philip I Murray
Research01 May 2000
Eye

Volume: 14, P: 302-306
Investigation of glucocorticoid-induced apoptotic pathway: Processing of Caspase-6 but not Caspase-3

Toshiyuki Miyashita
Kazuaki Nagao
Masao Yamada
Research01 Dec 1998
Cell Death & Differentiation

Volume: 5, P: 1034-1041
Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells

Yongjia Yu
Chuan-Yuan Li
John B Little
Research10 Apr 1997
Oncogene

Volume: 14, P: 1661-1667
Toil enables reproducible, open source, big biomedical data analyses

John Vivian
Arjun Arkal Rao
Benedict Paten
Correspondence11 Apr 2017
Nature Biotechnology

Volume: 35, P: 314-316
NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges

Commercializing innovations in academic environments is notoriously challenging. Here, we describe the progress of the NIH Centers for Accelerated Innovations program — initiated in 2013 to address these challenges — which we believe could help set a new standard for the early-stage commercialization of biomedical innovations in academic environments.

Elliott M. Antman
Paul E. Di Corleto
Lesley Watts
Comments & Opinion04 Aug 2017
Nature Reviews Drug Discovery

Volume: 16, P: 663-664
Publisher Correction: Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries

Seyedeh M. Zekavat
Sanni Ruotsalainen
Sebastian Zoellner
Amendments and CorrectionsOpen Access23 Aug 2018
Nature Communications

Volume: 9, P: 1-3

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