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Showing 51–98 of 98 results

Advanced filters: Author: JOSEPH ALTMAN Clear advanced filters

SPIRIT 2025 statement: updated guideline for protocols of randomized trials

SPIRIT 2025 provides updated guidance to authors, reviewers and editors, when preparing clinical trial protocols to enhance their transparency and completeness.

An-Wen Chan
Isabelle Boutron
Asbjørn Hróbjartsson
Reviews29 Apr 2025
Nature Medicine

Volume: 31, P: 1784-1792
Correction: Corrigendum: Genome sequencing in microfabricated high-density picolitre reactors

Marcel Margulies
Michael Egholm
Jonathan M. Rothberg
Amendments and Corrections26 Jan 2006
Nature

Volume: 439, P: 502
CONSORT 2025 statement: updated guideline for reporting randomized trials

CONSORT 2025 provides updated guidance to authors, reviewers and editors, when writing and evaluating manuscripts of randomized trials to ensure that trial reports are clear and transparent

Sally Hopewell
An-Wen Chan
Isabelle Boutron
Reviews15 Apr 2025
Nature Medicine

Volume: 31, P: 1776-1783
Murine cardiac fibrosis localization using adaptive Bayesian cardiac strain imaging in vivo

Rashid Al Mukaddim
Ashley M. Weichmann
Tomy Varghese
ResearchOpen Access20 May 2022
Scientific Reports

Volume: 12, P: 1-13
Local electrostatic imaging of striped domain order in LaAlO₃/SrTiO₃

The LaAlO₃/SrTiO₃ interface plays host to a diverse range of physical phenomena. By imaging the electrostatic landscape with a specially designed detector it is shown that tetragonal domains give rise to a large extrinsic piezoelectricity.

M. Honig
J. A. Sulpizio
S. Ilani
Research17 Nov 2013
Nature Materials

Volume: 12, P: 1112-1118
High Speed, High Density Intraoperative 3D Optical Topographical Imaging with Efficient Registration to MRI and CT for Craniospinal Surgical Navigation

Raphael Jakubovic
Daipayan Guha
Victor X. D. Yang
ResearchOpen Access05 Oct 2018
Scientific Reports

Volume: 8, P: 1-12
Automated 3D segmentation of methyl isocyanate-exposed rat trachea using an ultra-thin, fully fiber optic optical coherence endoscopic probe

Yusi Miao
Joseph C. Jing
Zhongping Chen
ResearchOpen Access07 Jun 2018
Scientific Reports

Volume: 8, P: 1-9
MILK TRANSPORT OF [³H]MELATONIN TO SUCKLING RATS

Steven M Reppert
David C Klein
Joseph D Schulman
Research01 Apr 1977
Pediatric Research

Volume: 11, P: 420
On the detection of cerebral metabolic depression in experimental traumatic brain injury using Chemical Exchange Saturation Transfer (CEST)-weighted MRI

Tsang-Wei Tu
Wael G. Ibrahim
Joseph A. Frank
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-12
Open source software for automatic detection of cone photoreceptors in adaptive optics ophthalmoscopy using convolutional neural networks

David Cunefare
Leyuan Fang
Sina Farsiu
ResearchOpen Access26 Jul 2017
Scientific Reports

Volume: 7, P: 1-11
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries

Genetic and functional studies implicate allele-specific regulation of OAS1 splicing and nonsense-mediated decay in COVID-19 severity. The OAS1 risk haplotype is also associated with reduced SARS-CoV-2 clearance in a clinical trial with pegIFN-λ1.

A. Rouf Banday
Megan L. Stanifer
Ludmila Prokunina-Olsson
ResearchOpen Access14 Jul 2022
Nature Genetics

Volume: 54, P: 1103-1116
Upper airway gene expression shows a more robust adaptive immune response to SARS-CoV-2 in children

The difference between children and adults in response to SARS-CoV-2 infection is not clearly established. Here the authors use gene expression analysis of nasopharyngeal samples from children and adults and show a higher level of immune response in children compared to adults, including of B and T cell activation.

Eran Mick
Alexandra Tsitsiklis
Charles R. Langelier
ResearchOpen Access08 Jul 2022
Nature Communications

Volume: 13, P: 1-11
Systematically higher Ki67 scores on core biopsy samples compared to corresponding resection specimen in breast cancer: a multi-operator and multi-institutional study

Balazs Acs
Samuel C. Y. Leung
Inti Zlobec
ResearchOpen Access21 Jun 2022
Modern Pathology

Volume: 35, P: 1362-1369
1172 EFFECTS OF CHRONIC HYPERGLYCEMIA IN THE FETAL LAMB

Anthony F Philipps
Joseph W Dubin
Arnold J Altman
Research01 Apr 1981
Pediatric Research

Volume: 15, P: 638
Validation of a three-dimensional body scanner for body composition measures

Michelle M. Harbin
Alexander Kasak
Donald R. Dengel
Research29 Dec 2017
European Journal of Clinical Nutrition

Volume: 72, P: 1191-1194
Intra-beat biomarker for accurate continuous non-invasive blood pressure monitoring

Arash Abiri
En-Fan Chou
Michelle Khine
ResearchOpen Access06 Oct 2022
Scientific Reports

Volume: 12, P: 1-13
High aboveground carbon stock of African tropical montane forests

The aboveground carbon stock of a montane African forest network is comparable to that of a lowland African forest network and two-thirds higher than default values for these montane forests.

Aida Cuni-Sanchez
Martin J. P. Sullivan
Etienne Zibera
Research25 Aug 2021
Nature

Volume: 596, P: 536-542
A kinase-cGAS cascade to synthesize a therapeutic STING activator

Leveraging enzymatic selectivity, a single reaction stream provides a single diastereomer of the cyclic dinucleotide MK-1454, a promising immune-oncology drug candidate, without the use of protecting groups or chiral auxiliaries.

John A. McIntosh
Zhijian Liu
Matthew L. Maddess
Research16 Mar 2022
Nature

Volume: 603, P: 439-444
Head and pelvis are the key segments recruited by adult spinal deformity patients during daily life activities

Elma Ayoub
Ali Rteil
Ayman Assi
ResearchOpen Access17 Sept 2024
Scientific Reports

Volume: 14, P: 1-16
Accuracy of the WatchBP Office Central as a Type 2 device for non-invasive estimation of central aortic blood pressure in children and adolescents

Jonathan P. Glenning
Kieran Sandhu
Jonathan P. Mynard
ResearchOpen Access13 Sept 2024
Journal of Human Hypertension

Volume: 38, P: 814-820
Pervasive acquisition of CRISPR memory driven by inter-species mating of archaea can limit gene transfer and influence speciation

A combination of genome sequencing of environmental archaeal isolates and experimental mating between Haloferax volcanii and Haloferax mediterranei shows that inter-species mating can induce the acquisition of CRISPR spacers, which modulate speciation.

Israela Turgeman-Grott
Shirley Joseph
Uri Gophna
Research26 Nov 2018
Nature Microbiology

Volume: 4, P: 177-186
Genome sequencing in microfabricated high-density picolitre reactors

Marcel Margulies
Michael Egholm
Jonathan M. Rothberg
ResearchOpen Access31 Jul 2005
Nature

Volume: 437, P: 376-380
Evaluation of SARS-CoV-2 serology assays reveals a range of test performance

Of 12 serology assays tested, four detect antibodies in more than 80% of patients with COVID-19.

Jeffrey D. Whitman
Joseph Hiatt
Alexander Marson
Research27 Aug 2020
Nature Biotechnology

Volume: 38, P: 1174-1183
Topical nitroglycerin to detect reversible microcirculatory dysfunction in patients with circulatory shock after cardiovascular surgery: an observational study

John C. Greenwood
Fatima M. Talebi
Benjamin S. Abella
ResearchOpen Access10 Sept 2022
Scientific Reports

Volume: 12, P: 1-9
1-¹³C-propionate breath testing as a surrogate endpoint to assess efficacy of liver-directed therapies in methylmalonic acidemia (MMA)

Irini Manoli
Alexandra R. Pass
Charles P. Venditti
ResearchOpen Access05 Apr 2021
Genetics in Medicine

Volume: 23, P: 1522-1533
Comparison of wavelet and correlation indices of cerebral autoregulation in a pediatric swine model of cardiac arrest

Xiuyun Liu
Xiao Hu
Jennifer K. Lee
ResearchOpen Access03 Apr 2020
Scientific Reports

Volume: 10, P: 1-9
Integrated and efficient diffusion-relaxometry using ZEBRA

Jana Hutter
Paddy J. Slator
Joseph V. Hajnal
ResearchOpen Access11 Oct 2018
Scientific Reports

Volume: 8, P: 1-13
Chemolithotrophic processes in the bacterial communities on the surface of mineral-enriched biochars

Jun Ye
Stephen D Joseph
Torsten Thomas
Research07 Feb 2017
The ISME Journal

Volume: 11, P: 1087-1101
A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease

Inglese et al. develop a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted magnetic resonance imaging scans. Their model reliably discriminates people with Alzheimer’s disease-related pathologies from those without.

Marianna Inglese
Neva Patel
Eric O. Aboagye
ResearchOpen Access20 Jun 2022
Communications Medicine

Volume: 2, P: 1-16
Correlating optic nerve sheath diameter with opening intracranial pressure in pediatric traumatic brain injury

Adam M.H. Young
Mathew R. Guilfoyle
Peter J. Hutchinson
Research11 Aug 2016
Pediatric Research

Volume: 81, P: 443-447
Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials

Gennaro Pagano
Dylan Trundell
Stefano Zanigni
ResearchOpen Access01 Jul 2025
npj Parkinson's Disease

Volume: 11, P: 1-8
Comprehensive multiscale analysis of lactate metabolic dynamics in vitro and in vivo using highly responsive biosensors

FiLa biosensors allow real-time subcellular analysis of lactate metabolism. This protocol describes their preparation and characterization, and their use in in vitro and in vivo assays, under various nutritional and pharmacological conditions.

Aoxue Wang
Yejun Zou
Yuzheng Zhao
Protocols02 Feb 2024
Nature Protocols

Volume: 19, P: 1311-1347
Exploratory digital outcome measures of motor sign progression in Parkinson’s disease patients treated with prasinezumab

Kirsten I. Taylor
Florian Lipsmeier
Stefano Zanigni
ResearchOpen Access16 Jun 2025
npj Digital Medicine

Volume: 8, P: 1-12
The clinical utility of CMV surveillance cultures and antigenemia following bone marrow transplantation

A Humar
K O’Rourke
T Mazzulli
Research22 Dec 1998
Bone Marrow Transplantation

Volume: 23, P: 45-51
Correlation of PD-1 and PD-L1 expression in oral leukoplakia and oral squamous cell carcinoma: an immunohistochemical study

L. R. Greeshma
Anna P. Joseph
Gopikrishnan Vijayakumar
ResearchOpen Access07 Dec 2023
Scientific Reports

Volume: 13, P: 1-10
CathAI: fully automated coronary angiography interpretation and stenosis estimation

Robert Avram
Jeffrey E. Olgin
Geoffrey H. Tison
ResearchOpen Access11 Aug 2023
npj Digital Medicine

Volume: 6, P: 1-12
Altered gene expression in slc4a11^−/− mouse cornea highlights SLC4A11 roles

Bernardo V. Alvarez
Marilyse Piché
Joseph R. Casey
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-15
Racial and ethnic differences in prenatal exposure to environmental phenols and parabens in the ECHO Cohort

Michael S. Bloom
Sudhi Upadhyaya
Lynne M. Smith
ResearchOpen Access15 Feb 2025
Journal of Exposure Science & Environmental Epidemiology

Volume: 35, P: 992-1002
Host factors are associated with vaginal microbiome structure in pregnancy in the ECHO Cohort Consortium

Kimberly McKee
Christine M. Bassis
Lynne M. Smith
ResearchOpen Access23 May 2024
Scientific Reports

Volume: 14, P: 1-19
Automatic Cone Photoreceptor Localisation in Healthy and Stargardt Afflicted Retinas Using Deep Learning

Benjamin Davidson
Angelos Kalitzeos
Christos Bergeles
ResearchOpen Access21 May 2018
Scientific Reports

Volume: 8, P: 1-13
Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity

The chemotherapeutic agent doxorubicin causes cardiac injury in a subset of cancer patients. This variable clinical response to doxorubicin treatment can be recapitulated in vitro by using cardiomyocytes derived from patient-specific induced pluripotent cells.

Paul W Burridge
Yong Fuga Li
Joseph C Wu
Research18 Apr 2016
Nature Medicine

Volume: 22, P: 547-556
Detection and quantification of Mycobacterium tuberculosis antigen CFP10 in serum and urine for the rapid diagnosis of active tuberculosis disease

Marva Seifert
Eva Vargas
Antonino Catanzaro
ResearchOpen Access28 Sept 2021
Scientific Reports

Volume: 11, P: 1-10
Targeting cancer metabolism in the era of precision oncology

Despite the link between metabolism and oncogenes, very few metabolism-based drugs for cancer have been successfully developed. This Review covers the setbacks and recent developments in targeting cancer metabolism, and discusses the path forward for the field.

Zachary E. Stine
Zachary T. Schug
Chi V. Dang
Reviews03 Dec 2021
Nature Reviews Drug Discovery

Volume: 21, P: 141-162
Author Correction: Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson’s disease trials

Gennaro Pagano
Dylan Trundell
Stefano Zanigni
Amendments and CorrectionsOpen Access13 Aug 2025
npj Parkinson's Disease

Volume: 11, P: 1
Effect of zinc supplementation on vitamin status of middle-aged and older European adults: the ZENITH study

F Intorre
A Polito
G Maiani
Research11 Jul 2007
European Journal of Clinical Nutrition

Volume: 62, P: 1215-1223
Mcl-1 antagonizes Bax/Bak to promote effector CD4⁺ and CD8⁺ T-cell responses

P Tripathi
B Koss
D A Hildeman
Research05 Apr 2013
Cell Death & Differentiation

Volume: 20, P: 998-1007
Characterization of SARS-CoV-2 antibodies in human milk from 21 women with confirmed COVID-19 infection

Lars Bode
Kerri Bertrand
Joseph J. Campo
ResearchOpen Access25 Nov 2022
Pediatric Research

Volume: 93, P: 1626-1633
Recommendations for achieving interoperable and shareable medical data in the USA

Szarfman et al. discuss the importance of efficient, easy access to large quantities of health data to improve medical care and further medical research. They outline the issues currently experienced accessing and exchanging data in the USA and provide recommendations for how to improve data access and exchange.

Ana Szarfman
Jonathan G. Levine
Russ B. Altman
ReviewsOpen Access18 Jul 2022
Communications Medicine

Volume: 2, P: 1-7

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