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Correction: Corrigendum: CD4⁺ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Nicole Boucheron
Roland Tschismarov
Wilfried Ellmeier
Amendments and Corrections19 Aug 2014
Nature Immunology

Volume: 15, P: 894
Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

A method for profiling alterations in protein thermal stability after ligand binding using mass spectrometry identifies the cellular protein targets of drugs and metabolites in living cells.

Kilian V M Huber
Karin M Olek
Giulio Superti-Furga
Research21 Sept 2015
Nature Methods

Volume: 12, P: 1055-1057
Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies

Emergence of drug tolerant cells drives adaptive targeted therapy resistance in non-small cell lung cancer (NSCLC). Here, the authors identify a common molecular event underpinning resistance to multiple targeted therapies in a panel of mutant NSCLC models that can be targeted with farnesyltransferase inhibition.

Sarah Figarol
Célia Delahaye
Olivier Calvayrac
ResearchOpen Access27 Jun 2024
Nature Communications

Volume: 15, P: 1-15
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

A chemoproteomic screen is used here to identify MTH1 as the target of SCH51344, an experimental RAS-dependent cancer drug; a further search for inhibitors revealed (S)-crizotinib as a potent MTH1 antagonist, which suppresses tumour growth in animal models of colon cancer, and could be part of a new class of anticancer drugs.

Kilian V. M. Huber
Eidarus Salah
Giulio Superti-Furga
Research02 Apr 2014
Nature

Volume: 508, P: 222-227
A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

A chemical-genetic study predicts mechanisms of resistance to PI3K inhibitors. Activation of NOTCH signaling, which leads to c-MYC expression, can overcome cancer cell dependency on PI3K signaling for growth. NOTCH and PI3K have not previously been linked in breast cancer.

Markus K Muellner
Iris Z Uras
Sebastian M B Nijman
Research25 Sept 2011
Nature Chemical Biology

Volume: 7, P: 787-793
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

The identity of the cytoplasmic DNA receptor that activates the inflammasome has remained elusive. Superti-Furga and colleagues use a proteomics screen to identity AIM2 as the DNA sensor for the inflammasome.

Tilmann Bürckstümmer
Christoph Baumann
Giulio Superti-Furga
Research21 Jan 2009
Nature Immunology

Volume: 10, P: 266-272
Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

Primary immunodeficiency disorders can be used to identify key immune functions. Here, the authors identify a biallelic mutation in the gene encoding NF-κB-inducing kinase in a family suffering a range of infections, and show that it causes defects in NK and T-cell function and has broad effects on B-cell function.

Katharina L. Willmann
Stefanie Klaver
Kaan Boztuğ
ResearchOpen Access19 Nov 2014
Nature Communications

Volume: 5, P: 1-13
A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

The use of a refined chemical library called the CeMM library of unique drugs (CLOUD) identified a synergistic interaction between flutamide and phenprocoumon in decreasing the growth of prostate cancer cells by regulating androgen receptor stability.

Marco P Licciardello
Anna Ringler
Stefan Kubicek
Research22 May 2017
Nature Chemical Biology

Volume: 13, P: 771-778
IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

The antiviral protein IFIT1 is upregulated substantially in the cytoplasm of virus-infected cells. Superti-Furga and colleagues show that IFIT1 is part of a virus-recognition pathway that sequesters specific viral RNA.

Andreas Pichlmair
Caroline Lassnig
Giulio Superti-Furga
Research05 Jun 2011
Nature Immunology

Volume: 12, P: 624-630
A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

Determining relevant targets of promiscuous kinase inhibitors has proven difficult. A combination of two mass spectrometry–based proteomic approaches, RNAi depletion and rescue studies with drug-resistant mutants now reveal that SRC, FYN and EGFR are functionally important targets of dasatinib in lung cancer cells.

Jiannong Li
Uwe Rix
Eric B Haura
Research28 Feb 2010
Nature Chemical Biology

Volume: 6, P: 291-299
Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Knapp and colleagues show that elevated heme levels following hemolysis impair the control of bacterial proliferation by inhibiting phagocytosis and migration of human and mouse phagocytes independently of heme-iron acquisition by bacteria as a source of nutrients.

Rui Martins
Julia Maier
Sylvia Knapp
Research31 Oct 2016
Nature Immunology

Volume: 17, P: 1361-1372
CD4⁺ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Histone deacetylases (HDACs) are crucial regulators of cell identity. Ellmeier and colleagues show that HDAC1 and HDAC2 maintain CD4⁺ T cell lineage integrity by repressing Runx-CBFβ complexes in T_H1 cells but not in T_H2 cells.

Nicole Boucheron
Roland Tschismarov
Wilfried Ellmeier
Research30 Mar 2014
Nature Immunology

Volume: 15, P: 439-448
Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

A systems-pharmacology approach reveals that the combined off-target activity of two kinase inhibitors that impedes MAPK signaling to decrease expression of Myc target genes increases apoptosis in CML cells containing gatekeeper mutations in BCR-ABL.

Georg E Winter
Uwe Rix
Giulio Superti-Furga
Research30 Sept 2012
Nature Chemical Biology

Volume: 8, P: 905-912
An R package for generic modular response analysis and its application to estrogen and retinoic acid receptor crosstalk

Gabriel Jimenez-Dominguez
Patrice Ravel
Jacques Colinge
ResearchOpen Access31 Mar 2021
Scientific Reports

Volume: 11, P: 1-14
A reversible gene trap collection empowers haploid genetics in human cells

A collection of single-gene-mutant human cells is described. This growing resource is based on gene-trap mutagenesis of a near-haploid human cell line and covers almost 3,500 human genes.

Tilmann Bürckstümmer
Carina Banning
Sebastian M B Nijman
Research25 Aug 2013
Nature Methods

Volume: 10, P: 965-971
Viral immune modulators perturb the human molecular network by common and unique strategies

A systems approach provides a global perspective of the different strategies that viruses use to modulate the cellular innate immune response; this may be useful in the design of future viral intervention strategies.

Andreas Pichlmair
Kumaran Kandasamy
Giulio Superti-Furga
Research18 Jul 2012
Nature

Volume: 487, P: 486-490
Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

A systematic study of the intra- and interlaboratory reproducibility of a standardized affinity purification–mass spectrometry protocol demonstrates the high reproducibility of this technique and hints at the feasibility of a large-scale human interactome project through interlaboratory efforts.

Markku Varjosalo
Roberto Sacco
Giulio Superti-Furga
Research03 Mar 2013
Nature Methods

Volume: 10, P: 307-314
ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment

Marine Bruciamacchie
Véronique Garambois
Christel Larbouret
Research29 Nov 2024
British Journal of Cancer

Volume: 132, P: 222-235
The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

The Contaminant Repository for Affinity Purification (CRAPome) is a database of annotated negative control-data that can be used for filtering out nonspecific interactions in affinity purification-mass spectrometry experiments.

Dattatreya Mellacheruvu
Zachary Wright
Alexey I Nesvizhskii
Research07 Jul 2013
Nature Methods

Volume: 10, P: 730-736
Mechanical signatures of human colon cancers

Evelyne Lopez-Crapez
Luca Costa
Christine Bénistant
ResearchOpen Access21 Jul 2022
Scientific Reports

Volume: 12, P: 1-13
MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

Diala Kantar
Emilie Bousquet Mur
Alexandre Djiane
ResearchOpen Access11 Mar 2021
Scientific Reports

Volume: 11, P: 1-20
A time-resolved molecular map of the macrophage response to VSV infection

Richard K Kandasamy
Gregory I Vladimer
Giulio Superti-Furga
ResearchOpen Access27 Oct 2016
npj Systems Biology and Applications

Volume: 2, P: 1-12
Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions

Joana C. Silva
Emmanuel Cornillot
Choukri Ben Mamoun
ResearchOpen Access18 Oct 2016
Scientific Reports

Volume: 6, P: 1-15

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Correction: Corrigendum: CD4⁺ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

Farnesyltransferase inhibition overcomes oncogene-addicted non-small cell lung cancer adaptive resistance to targeted therapies

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

IFIT1 is an antiviral protein that recognizes 5′-triphosphate RNA

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

CD4⁺ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2

Systems-pharmacology dissection of a drug synergy in imatinib-resistant CML

An R package for generic modular response analysis and its application to estrogen and retinoic acid receptor crosstalk

A reversible gene trap collection empowers haploid genetics in human cells

Viral immune modulators perturb the human molecular network by common and unique strategies

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS

ATR inhibition potentiates FOLFIRINOX cytotoxic effect in models of pancreatic ductal adenocarcinoma by remodelling the tumour microenvironment

The CRAPome: a contaminant repository for affinity purification–mass spectrometry data

Mechanical signatures of human colon cancers

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

A time-resolved molecular map of the macrophage response to VSV infection

Genome-wide diversity and gene expression profiling of Babesia microti isolates identify polymorphic genes that mediate host-pathogen interactions

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