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Showing 1–3 of 3 results
Advanced filters: Author: Jacques Grosset Clear advanced filters

  • Authors perform an analysis of the patient data and risk factors to evaluate unfavorable outcomes and adverse events in adults with pulmonary tuberculosis treated with a 4-month rifapentine based regimen. Low rifapentine exposure was the most clinically significant risk factor for treatment failure and tuberculosis relapse.

    • Vincent K. Chang
    • Marjorie Z. Imperial
    • Elizabeth Guy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-12

  • Alexander Pym, Ashlee Earl and colleagues use the whole-genome sequences from 498 strains of Mycobacterium tuberculosis to identify new genotypes conferring resistance to antitubercular drugs. They find that loss-of-function mutations in ald (Rv2780), encoding L-alanine dehydrogenase, are associated with unexplained drug resistance and demonstrate that these mutations confer resistance to D-cycloserine.

    • Christopher A Desjardins
    • Keira A Cohen
    • Alexander S Pym
    Research
    Nature Genetics
    Volume: 48, P: 544-551