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Showing 1–7 of 7 results
Advanced filters: Author: Jacques I Wadiche Clear advanced filters

  • Glutamate that diffuses out of the synaptic cleft can have actions at distant receptors, a mode of transmission called spillover. Here, the authors find in the cerebellar cortex that glutamate spillover from climbing fibers activates synaptic AMPA receptors of molecular layer interneurons, allowing glutamate from an unconnected pathway to co-opt postsynaptic receptors.

    • Reagan L. Pennock
    • Luke T. Coddington
    • Jacques I. Wadiche
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • It has become apparent that, in addition to removing excess extracellular glutamate, glutamate transporters can help to shape synaptic events. Tzingounis and Wadiche review the structural properties and regulation of glutamate transporters, highlighting their diverse roles in key brain regions.

    • Anastassios V. Tzingounis
    • Jacques I. Wadiche
    Reviews
    Nature Reviews Neuroscience
    Volume: 8, P: 935-947

  • Immature dentate gyrus neurons are highly excitable and are thought to be more responsive to afferent activity than mature neurons. Here, the authors find stimulation of the entorhinal cortex paradoxically generates spiking in mature rather than immature neurons due to low synaptic connectivity of immature cells.

    • Cristina V. Dieni
    • Roberto Panichi
    • Linda Overstreet-Wadiche
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Maturation of adult-born neurons in the dentate gyrus is known to require GABAergic input. Here the authors show that a subtype of interneurons, namely neurogliaform cells, acts as the primary source of GABA for newborn neurons in mouse dentate gyrus.

    • Sean J Markwardt
    • Cristina V Dieni
    • Linda Overstreet-Wadiche
    Research
    Nature Neuroscience
    Volume: 14, P: 1407-1409

  • Glutamate transporters have long been thought to help terminate the synaptic response through neurotransmitter binding and reuptake, but a new report in this issue identifies a role for their anionic current in information transmission in the retina.

    • Jacques I Wadiche
    • Henrique von Gersdorff
    News & Views
    Nature Neuroscience
    Volume: 9, P: 1352-1353