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Extrathymic expression of Aire controls the induction of effective T_H17 cell-mediated immune response to Candida albicans

Abramson and colleagues show that Aire⁺MHCII⁺ ILC3s sense, internalize and present Candida albicans and modulate the induction of C. albicans-specific T_H17 cells.

Jan Dobeš
Osher Ben-Nun
Jakub Abramson
Research27 Jun 2022
Nature Immunology

Volume: 23, P: 1098-1108
Author Correction: Thymic mimetic cells function beyond self-tolerance

Tal Givony
Dena Leshkowitz
Jakub Abramson
Amendments and Corrections30 Nov 2023
Nature

Volume: 624, P: E4
Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations

Rare immune or stem cell populations are difficult to quantitatively analyze for protein-protein interactions or post-translational modifications despite advances in proteomics. Here the authors develop proximity ligation imaging cytometry for high-resolution detection at a single cell level.

Ayelet Avin
Maayan Levy
Jakub Abramson
ResearchOpen Access15 Nov 2017
Nature Communications

Volume: 8, P: 1-10
The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Dysfunction of the deacetylase Sirt1 has been associated with certain metabolic diseases. Abramson and colleagues show that Sirt1 has high expression in the thymus, where it deacetylates the transcriptional regulator Aire and is essential for Aire's ability to switch on the expression of tissue-specific genes.

Anna Chuprin
Ayelet Avin
Jakub Abramson
Research25 May 2015
Nature Immunology

Volume: 16, P: 737-745
Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

A large fraction of patients with APS-1 and coeliac disease develop enamel dystrophy, characterized by the presence of autoantibodies against the enamel matrix, which are generated through the breakdown of either central (APS-1) or peripheral (coeliac) tolerance to a battery of ameloblast-sepecific proteins.

Yael Gruper
Anette S. B. Wolff
Jakub Abramson
Research22 Nov 2023
Nature

Volume: 624, P: 653-662
Thymic mimetic cells function beyond self-tolerance

Multiomic analyses of mouse thymic epithelial cells identify several unconventional subsets that are mimetics of various populations of terminally differentiated parenchymal cells and provide insights into their development, molecular features and function.

Tal Givony
Dena Leshkowitz
Jakub Abramson
Research06 Sept 2023
Nature

Volume: 622, P: 164-172
Transcriptional programs that control expression of the autoimmune regulator gene Aire

Abramson and colleagues show that the coordinated action of several transcriptional regulators, including Irf4, Irf8, Tbx21, Tcf7 and Ctcfl, acts on medullary-thymic-epithelial-cell-specific accessible regions in the locus encoding the transcriptional regulator Aire to control its expression.

Yonatan Herzig
Shir Nevo
Jakub Abramson
Research12 Dec 2016
Nature Immunology

Volume: 18, P: 161-172
Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

In an analysis of long-term safety events in 783 patients treated with T cell therapy in 38 trials, 2.3% of patients developed second primary malignancies, and vector integration analyses revealed no pathological insertions.

Julie K. Jadlowsky
Elizabeth O. Hexner
Joseph A. Fraietta
Research20 Jan 2025
Nature Medicine

Volume: 31, P: 1134-1144
The emerging family of RORγt⁺ antigen-presenting cells

Recent studies have revealed a family of antigen-presenting cells (APCs) marked by the transcription factor RORγt that fundamentally shape immunity, inflammation and tolerance. This article reviews heterogeneity among RORγt⁺ APCs, their associated functions and the future promise of this new field.

Jakub Abramson
Jan Dobeš
Gregory F. Sonnenberg
Reviews21 Jul 2023
Nature Reviews Immunology

Volume: 24, P: 64-77
Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

A comprehensive characterization of the thymic stroma identifies a tuft-cell-like thymic epithelial cell population that is critical for shaping the immune niche in the thymus.

Chamutal Bornstein
Shir Nevo
Ido Amit
Research18 Jul 2018
Nature

Volume: 559, P: 622-626
Computational optimization of antibody humanness and stability by systematic energy-based ranking

A computational method for the systematic grafting of animal complementarity-determining regions onto thousands of human frameworks allows for the design of humanized versions of antibodies with improved stability.

Ariel Tennenhouse
Lev Khmelnitsky
Sarel J. Fleishman
Research07 Aug 2023
Nature Biomedical Engineering

Volume: 8, P: 30-44
The BTLA–HVEM axis restricts CAR T cell efficacy in cancer

Here the authors show that BTLA on effector T cells interacts with HVEM on other immunosuppressive cells in the tumor microenvironment. The authors also present evidence that overcoming this checkpoint can ehance CAR T functionality.

Puneeth Guruprasad
Alberto Carturan
Marco Ruella
Research03 Jun 2024
Nature Immunology

Volume: 25, P: 1020-1032
Rbpj expression in regulatory T cells is critical for restraining T_H2 responses

Transcriptional regulator Rbpj is involved in T-helper subset differentiation. Here the authors show that expression of Rbpj in regulatory T cells is required to both regulate T_H2 responses and regulate T_reg T_H2 differentiation potential.

Michael Delacher
Christian Schmidl
Markus Feuerer
ResearchOpen Access08 Apr 2019
Nature Communications

Volume: 10, P: 1-20
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Katy Börner
Philip D. Blood
Bruce W. Herr II
ResearchOpen Access13 Mar 2025
Nature Methods

Volume: 22, P: 845-860
Thymic epithelial cell heterogeneity: TEC by TEC

Recent studies using single-cell genomic technologies and in vivo fate mapping have shown that thymic epithelial cells are far more heterogeneous than previously thought, comprising multiple subpopulations with distinct molecular and functional characteristics.

Noam Kadouri
Shir Nevo
Jakub Abramson
Reviews05 Dec 2019
Nature Reviews Immunology

Volume: 20, P: 239-253
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

In an analysis of adult patients with hematologic malignancies who received anti-CD19 chimeric antigen receptor T cell therapy, baseline gut microbiome composition was correlated with clinical response and treatment with broad-spectrum antibiotics in the four weeks prior to infusion was associated with worse survival and increased neurotoxicity.

Melody Smith
Anqi Dai
Marco Ruella
Research14 Mar 2022
Nature Medicine

Volume: 28, P: 713-723
Author Correction: Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

Melody Smith
Anqi Dai
Marco Ruella
Amendments and Corrections17 Oct 2022
Nature Medicine

Volume: 29, P: 2954
T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy

Profiling of a case of secondary T cell lymphoma following anti-CD19 CAR T cell therapy suggests that it was not caused by CAR insertional mutagenesis, with single-center analysis indicating that secondary T cell lymphoma risk after commercial CAR T cell treatment is low.

Guido Ghilardi
Joseph A. Fraietta
Marco Ruella
Research24 Jan 2024
Nature Medicine

Volume: 30, P: 984-989
Outcomes in patients with classic Hodgkin lymphoma refractory or intolerant to brentuximab vedotin and anti-PD-1 therapy: a real world analysis from 15 U.S. academic centers

Timothy J. Voorhees
Eric M. McLaughlin
Narendranath Epperla
ResearchOpen Access26 Mar 2025
Blood Cancer Journal

Volume: 15, P: 1-7
Z-DNA marks the spot for AIRE

Yael Goldfarb
Jakub Abramson
Research Highlights29 Apr 2024
Cell Research

Volume: 34, P: 537-538
Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation

J Svoboda
C Andreadis
S J Schuster
Research12 Jun 2006
Bone Marrow Transplantation

Volume: 38, P: 211-216

Search

Extrathymic expression of Aire controls the induction of effective T_H17 cell-mediated immune response to Candida albicans

Author Correction: Thymic mimetic cells function beyond self-tolerance

Quantitative analysis of protein-protein interactions and post-translational modifications in rare immune populations

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

Autoimmune amelogenesis imperfecta in patients with APS-1 and coeliac disease

Thymic mimetic cells function beyond self-tolerance

Transcriptional programs that control expression of the autoimmune regulator gene Aire

Long-term safety of lentiviral or gammaretroviral gene-modified T cell therapies

The emerging family of RORγt⁺ antigen-presenting cells

Single-cell mapping of the thymic stroma identifies IL-25-producing tuft epithelial cells

Computational optimization of antibody humanness and stability by systematic energy-based ranking

The BTLA–HVEM axis restricts CAR T cell efficacy in cancer

Rbpj expression in regulatory T cells is critical for restraining T_H2 responses

Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

Thymic epithelial cell heterogeneity: TEC by TEC

Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

Author Correction: Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy

T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy

Outcomes in patients with classic Hodgkin lymphoma refractory or intolerant to brentuximab vedotin and anti-PD-1 therapy: a real world analysis from 15 U.S. academic centers

Z-DNA marks the spot for AIRE

Prognostic value of FDG-PET scan imaging in lymphoma patients undergoing autologous stem cell transplantation

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