Legrand et al. identify two lysine residues on molecular surface of Fibroblast Growth Factor 2 (FGF2) essential for its interaction with α1 subunit of the Na,K-ATPase. They further conclude that this interaction precedes interaction of the FGF2 with PI(4,5)P2 and facilitates its unconventional secretion across the membrane, which is impaired by Ouabain, an Na,K-ATPase inhibitor.
- Cyril Legrand
- Roberto Saleppico
- Walter Nickel
