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Showing 1–10 of 10 results
Advanced filters: Author: Janosch Hennig Clear advanced filters

  • The RNA-binding ubiquitin E3 ligase TRIM25 plays a critical role in antiviral immunity. Here the authors identify key RNA-binding residues of TRIM25, link RNA binding to antiviral activity, reveal RNA structural and sequence preferences, and investigate binding to the viral genome.

    • Lucía Álvarez
    • Kevin Haubrich
    • Janosch Hennig
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The chloroplast signal recognition particle delivers LHCPs to the thylakoid membrane by interaction of cpSRP43 with the Alb3 insertase. Here the authors decipher the specific recognition of the Alb3 C-terminal tail within the interface of two communicating chromodomains by structural biochemistry.

    • Annemarie Horn
    • Janosch Hennig
    • Irmgard Sinning
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Here, the authors elucidate how sequential activities of opposite-polarity microtubule motors are coordinated on a cargo, by showing how the Tm1 protein inhibits kinesin-1 during delivery of oskar RNA into the Drosophila oocyte by dynein.

    • Simone Heber
    • Mark A. McClintock
    • Anne Ephrussi
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 476-488

  • The molecular steps that lead to the disaggregation of amyloid fibrils are shown to involve the synergistic action of HSP70 and its co-chaperones DNAJB1 and HSP110.

    • Anne S. Wentink
    • Nadinath B. Nillegoda
    • Bernd Bukau
    Research
    Nature
    Volume: 587, P: 483-488

  • An analysis of the interactions between 15 drugs and 25 gut bacterial strains shows that bioaccumulation of drugs within bacterial cells is another mechanism through which gut microorganisms can alter drug availability and efficacy.

    • Martina Klünemann
    • Sergej Andrejev
    • Kiran R. Patil
    Research
    Nature
    Volume: 597, P: 533-538

  • Although transcription factor (TF) cooperativity is widespread, a global mechanistic understanding of the role of TF cooperativity is still lacking. Here the authors introduce a statistical learning framework that provides structural insight into TF cooperativity and its functional consequences based on next generation sequencing data and provide mechanistic insights into TF cooperativity and its impact on protein-phenotype interactions.

    • Ignacio L. Ibarra
    • Nele M. Hollmann
    • Judith B. Zaugg
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-16

  • NS1 of influenza A virus inhibits TRIM25 activity, which is an E3 ligase important for induction of the interferon response. Here, Koliopoulos et al. present structures of TRIM25 and NS1 and show how NS1 binding interferes with substrate recognition of TRIM25.

    • Marios G. Koliopoulos
    • Mathilde Lethier
    • Katrin Rittinger
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13

  • The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex, highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein–RNA architecture.

    • Janosch Hennig
    • Cristina Militti
    • Michael Sattler
    Research
    Nature
    Volume: 515, P: 287-290