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Showing 1–8 of 8 results

Advanced filters: Author: Jarod A. Zepp Clear advanced filters

Act1 mediates IL-17–induced EAE pathogenesis selectively in NG2⁺ glial cells

In this study, the authors show that depletion of the IL-17 signaling component, Act1, specifically from NG2⁺ glia led to a substantial reduction in the severity of pathology in an EAE mouse model. They also find that IL-17 induces apoptosis of NG2⁺ cells in an Act1-dependent manner.

Zizhen Kang
Chenhui Wang
Xiaoxia Li
Research01 Sept 2013
Nature Neuroscience

Volume: 16, P: 1401-1408
Emergence of inflammatory fibroblasts with aging in Hermansky-Pudlak syndrome associated pulmonary fibrosis

Single cell RNA sequencing atlases of HermanskyPudlak syndrome elucidate cellular abnormalities including emergence of inflammatory fibroblasts that are associated with pulmonary fibrosis.

Brandon J. H. Banaschewski
Sylvia N. Michki
Lisa R. Young
ResearchOpen Access22 Feb 2025
Communications Biology

Volume: 8, P: 1-18
STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury

Paris et al. show that after injury or influenza infection alveolar type II cells signal via a STAT3–BDNF axis that activates the TrkB receptor on mesenchymal niche cells and enhances alveolar repair.

Andrew J. Paris
Katharina E. Hayer
G. Scott Worthen
Research28 Sept 2020
Nature Cell Biology

Volume: 22, P: 1197-1210
IL-37 is a fundamental inhibitor of innate immunity

The function of IL-37 remains elusive. Dinarello and colleagues find that IL-37 acts as a natural suppressor of innate inflammatory and immune responses.

Marcel F Nold
Claudia A Nold-Petry
Charles A Dinarello
Research10 Oct 2010
Nature Immunology

Volume: 11, P: 1014-1022
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

Psoriasis is associated with heightened T_H17 responses. Li and colleagues show that the IL-17R signaling adaptor Act1 requires the chaperone protein hsp90. Defective signaling leads to exuberant IL-22 production and enhanced disease.

Chenhui Wang
Ling Wu
Xiaoxia Li
Research02 Dec 2012
Nature Immunology

Volume: 14, P: 72-81
T cell–intrinsic ASC critically promotes T_H17-mediated experimental autoimmune encephalomyelitis

Inflammasome activation triggers the release of active interleukin 1β (IL-1β). Li and colleagues show that T_H17 cells can release IL-1β upon T cell antigen receptor and ATP stimulation via an ASC–NLPR3–caspase-8 axis, thereby contributing to neuroinflammation.

Bradley N Martin
Chenhui Wang
Xiaoxia Li
Research21 Mar 2016
Nature Immunology

Volume: 17, P: 583-592
Regeneration of the lung alveolus by an evolutionarily conserved epithelial progenitor

An evolutionarily conserved alveolar epithelial progenitor lineage that derives from alveolar type 2 cells is responsive to Wnt signalling and acts as a major facultative progenitor in regenerating the distal lung.

William J. Zacharias
David B. Frank
Edward E. Morrisey
Research28 Feb 2018
Nature

Volume: 555, P: 251-255
Cellular crosstalk in the development and regeneration of the respiratory system

The respiratory system comprises multiple cell types, and consequently its development and regeneration involves intricate cellular crosstalk. Better understanding of these complex cellular interactions will improve the treatment of respiratory diseases and tissue repair after injury.

Jarod A. Zepp
Edward E. Morrisey
Reviews19 Jun 2019
Nature Reviews Molecular Cell Biology

Volume: 20, P: 551-566