Nature Search

Impact of SARS-CoV-2 infection therapies on the risk of venous thromboembolism and cardiovascular events from the SEMI-COVID-19 Registry

Crhistian-Mario Oblitas
Pablo Demelo-Rodríguez
Hector Meijide Míguez
ResearchOpen Access05 Mar 2025
Scientific Reports

Volume: 15, P: 1-13
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

Analysis of 2,170 SARS-CoV-2 sequences from the first wave of the COVID-19 epidemic in Spain provides insights into transmission patterns and the effects of lockdown on the emergence of new variants.

Mariana G. López
Álvaro Chiner-Oms
Iñaki Comas
Research30 Sept 2021
Nature Genetics

Volume: 53, P: 1405-1414
Geriatric muscle stem cells switch reversible quiescence into senescence

This study shows that ageing satellite cells undergo an irreversible transition from a quiescent to a pre-senescent state that results in the loss of muscle regeneration in sarcopenia; furthermore, increased expression of p16^INK4a is identified as a common feature of senescent satellite cells.

Pedro Sousa-Victor
Susana Gutarra
Pura Muñoz-Cánoves
Research12 Feb 2014
Nature

Volume: 506, P: 316-321
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression

The authors show that knocking out SMAD4, human NK cells resist TGFβ and activin A suppression and demonstrate that SMAD4 knockout enhances the antitumor function of several NK cell products in clinical development.

Anna Rea
Sara Santana-Hernández
Aura Muntasell
ResearchOpen Access21 Mar 2025
Nature Immunology

Volume: 26, P: 582-594
Absence of MCJ/DnaJC15 promotes brown adipose tissue thermogenesis

How adipose mitochondria activity is fine-tuned in response to obesity is an active area of study. Here, the authors show that mitochondrial protein MCJ can block thermogenesis and that silencing this gene can correct obesity-related comorbidities.

Beatriz Cicuéndez
Alfonso Mora
Guadalupe Sabio
ResearchOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1-16
Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

José-Manuel Casas-Rojo
Juan-Miguel Antón-Santos
Hector Meijide Míguez
ResearchOpen Access18 Oct 2023
Scientific Reports

Volume: 13, P: 1-18
A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li–Fraumeni-like families

Genetic factors that cause cardiac angiosarcoma are unknown. Calveteet al. show that a missense mutation in protection of telomeres1 (POT1) gene causes cardiac angiosarcoma by affecting the POT1 function and, consequently, telomere length and stability.

Oriol Calvete
Paula Martinez
Javier Benítez
ResearchOpen Access25 Sept 2015
Nature Communications

Volume: 6, P: 1-12
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism

A comprehensive analysis of models of brain metastasis and multiple cohorts of patient samples identifies a targetable molecular mechanism underlying the resistance to whole-brain radiotherapy that can inform patient selection for personalized radiotherapy.

Cátia Monteiro
Lauritz Miarka
Manuel Valiente
ResearchOpen Access11 Apr 2022
Nature Medicine

Volume: 28, P: 752-765
Decapping protein EDC4 regulates DNA repair and phenocopies BRCA1

Mutations in BRCA1 are associated with an increased risk of breast and ovarian cancer. Here the authors show that EDC4, a component of P-bodies, is a member of the BRCA1 complex with roles in stimulating end resection at breaks.

Gonzalo Hernández
María José Ramírez
Jordi Surrallés
ResearchOpen Access06 Mar 2018
Nature Communications

Volume: 9, P: 1-11
Strain-induced coupling of electrical polarization and structural defects in SrMnO₃ films

An array of nanoscale polar domains with varying conductance and that are electrically insulated by domain walls can be induced by the interplay of strain and defects in oxide thin films.

Carsten Becher
Laura Maurel
Manfred Fiebig
Research01 Jun 2015
Nature Nanotechnology

Volume: 10, P: 661-665
γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

The switch from glucose- to fatty acid-dependent metabolism in cardiomyocytes of newborn mice is governed by γ-linolenic acid in maternal milk, which binds to retinoid X receptors, thereby causing a transcription-dependent metabolic transition.

Ana Paredes
Raquel Justo-Méndez
Mercedes Ricote
Research24 May 2023
Nature

Volume: 618, P: 365-373
Further delineation of neuropsychiatric findings in Tatton-Brown-Rahman syndrome due to disease-causing variants in DNMT3A: seven new patients

Jair Tenorio
Pablo Alarcón
Pablo Lapunzina
Research04 Nov 2019
European Journal of Human Genetics

Volume: 28, P: 469-479
Spread of a SARS-CoV-2 variant through Europe in the summer of 2020

Analysis of the spread of the 20E (EU1) variant of SARS-CoV-2 through Europe suggests that international travel and insufficient containment, rather than increased transmissibility, led to a resurgence of infections.

Emma B. Hodcroft
Moira Zuber
Richard A. Neher
Research07 Jun 2021
Nature

Volume: 595, P: 707-712
Highly parallel direct RNA sequencing on an array of nanopores

Direct sequencing of RNA molecules in real time using nanopores allows for the detection of splice variants and hold promises for profiling RNA modifications.

Daniel R Garalde
Elizabeth A Snell
Daniel J Turner
Research15 Jan 2018
Nature Methods

Volume: 15, P: 201-206
Author Correction: γ-Linolenic acid in maternal milk drives cardiac metabolic maturation

Ana Paredes
Raquel Justo-Méndez
Mercedes Ricote
Amendments and Corrections15 Jun 2023
Nature

Volume: 619, P: E24
Phenotypic changes of HER2-positive breast cancer during and after dual HER2 blockade

HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment.

Fara Brasó-Maristany
Gaia Griguolo
Aleix Prat
ResearchOpen Access20 Jan 2020
Nature Communications

Volume: 11, P: 1-11
Modulation of telomere protection by the PI3K/AKT pathway

Regulation of telomeres and the insulin/PI3K pathway both have roles in aging and cancer development but have not been functionally linked. Here the authors demonstrate that PI3K, via downstream targets, regulates TRF1 via phosphorylation.

Marinela Méndez-Pertuz
Paula Martínez
Maria A. Blasco
ResearchOpen Access02 Nov 2017
Nature Communications

Volume: 8, P: 1-17
BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

Mutations in BRCA2 are associated with higher susceptibility to some forms of cancer. BRCA2 is known to play a central role in the repair of DNA breaks via homologous recombination. Now a role for BRCA2 in telomere integrity is revealed, indicating that BRCA2 can contribute to genome stability in multiple ways.

Sophie Badie
Jose M Escandell
Madalena Tarsounas
Research14 Nov 2010
Nature Structural & Molecular Biology

Volume: 17, P: 1461-1469
Comparison of seven prognostic tools to identify low-risk pulmonary embolism in patients aged <50 years

Luis Jara-Palomares
Maria Alfonso
Abilio Reis
ResearchOpen Access27 Dec 2019
Scientific Reports

Volume: 9, P: 1-10
Sero-epidemiological study of the rotavirus VP8* protein from different P genotypes in Valencia, Spain

Susana Vila-Vicent
Roberto Gozalbo-Rovira
Jesús Rodríguez-Díaz
ResearchOpen Access08 May 2020
Scientific Reports

Volume: 10, P: 1-9
The maternal genetic make-up of the Iberian Peninsula between the Neolithic and the Early Bronze Age

Anna Szécsényi-Nagy
Christina Roth
Kurt W. Alt
ResearchOpen Access15 Nov 2017
Scientific Reports

Volume: 7, P: 1-15
Recent Advances in Reproductive Genetic Technologies

Gene Levinson
Carolyn B. Coulam
Joseph D. Schulman
Reviews01 Sept 1995
Bio/Technology

Volume: 13, P: 968-973
Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula)

Arnaud Gaigher
Alessia Rota
Ana Veríssimo
ResearchOpen Access07 Mar 2023
Scientific Reports

Volume: 13, P: 1-14
Time-scale synchronisation of oscillatory responses can lead to non-monotonous R-tipping

Jan Swierczek-Jereczek
Alexander Robinson
Marisa Montoya
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-9
Risk factors for developing ventilator-associated lower respiratory tract infection in patients with severe COVID-19: a multinational, multicentre study, prospective, observational study

Luis Felipe Reyes
Alejandro Rodriguez
Neus Guasch
ResearchOpen Access21 Apr 2023
Scientific Reports

Volume: 13, P: 1-15
A protective bivalent vaccine against Rift Valley fever and bluetongue

Eva Calvo-Pinilla
Alejandro Marín-López
Javier Ortego
ResearchOpen Access30 Jul 2020
npj Vaccines

Volume: 5, P: 1-12
A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia

Paula Jiménez Fonseca
Alberto Carmona-Bayonas
Francisco Ayala
ResearchOpen Access17 May 2016
British Journal of Cancer

Volume: 114, P: 1191-1198
Real world data of anticoagulant treatment in non-valvular atrial fibrillation across renal function status

Jose Miguel Calderon
Fernando Martinez
Maria Jose Forner
ResearchOpen Access12 Apr 2022
Scientific Reports

Volume: 12, P: 1-10
X chromosome inactivation does not necessarily determine the severity of the phenotype in Rett syndrome patients

Clara Xiol
Silvia Vidal
Cristina Villar
ResearchOpen Access19 Aug 2019
Scientific Reports

Volume: 9, P: 1-9
Consumption of caffeinated beverages and kidney function decline in an elderly Mediterranean population with metabolic syndrome

Andrés Díaz-López
Indira Paz-Graniel
Jordi Salas-Salvadó
ResearchOpen Access22 Apr 2021
Scientific Reports

Volume: 11, P: 1-13
The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome

Silvia Vidal
Núria Brandi
Cristina Villar
ResearchOpen Access25 Sept 2017
Scientific Reports

Volume: 7, P: 1-11
Freshwater macroinvertebrate samples from a water quality monitoring network in the Iberian Peninsula

Nora Escribano
Javier Oscoz
Arturo H. Ariño
ResearchOpen Access05 Jun 2018
Scientific Data

Volume: 5, P: 1-6
Role of obesity in the release of extracellular nucleosomes in acute pancreatitis: a clinical and experimental study

Salvador Pérez
Isabela Finamor
Juan Sastre
Research01 May 2018
International Journal of Obesity

Volume: 43, P: 158-168
Compact, cost-effective and field-portable microscope prototype based on MISHELF microscopy

Martín Sanz
José Ángel Picazo-Bueno
Vicente Micó
ResearchOpen Access24 Feb 2017
Scientific Reports

Volume: 7, P: 1-12
The continuity of effect of schizophrenia polygenic risk score and patterns of cannabis use on transdiagnostic symptom dimensions at first-episode psychosis: findings from the EU-GEI study

Diego Quattrone
Ulrich Reininghaus
Giuseppe D’Andrea
ResearchOpen Access10 Aug 2021
Translational Psychiatry

Volume: 11, P: 1-10
Long-term effects of medical management on growth and weight in individuals with urea cycle disorders

Roland Posset
Sven F. Garbade
Maja Djordjevic
ResearchOpen Access20 Jul 2020
Scientific Reports

Volume: 10, P: 1-13
Molecular epidemiology, genotype–phenotype correlation and BH₄ responsiveness in Spanish patients with phenylketonuria

Luis Aldámiz-Echevarría
Marta Llarena
María L Couce
Research28 Apr 2016
Journal of Human Genetics

Volume: 61, P: 731-744
Genotype and phenotype characterization in a Spanish cohort with isovaleric acidemia

María L Couce
Luís Aldamiz-Echevarría
Celia Pérez-Cerdá
Research01 Dec 2016
Journal of Human Genetics

Volume: 62, P: 355-360
Author Correction: The utility of Next Generation Sequencing for molecular diagnostics in Rett syndrome

Silvia Vidal
Núria Brandi
Cristina Villar
Amendments and CorrectionsOpen Access07 Sept 2021
Scientific Reports

Volume: 11, P: 1-2
Analysis of the Spanish national registry for pediatric home enteral nutrition (NEPAD): implementation rates and observed trends during the past 8 years

C Pedrón-Giner
V M Navas-López
B Pérez-Moneo
Research06 Feb 2013
European Journal of Clinical Nutrition

Volume: 67, P: 318-323

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