The recognition of histone post-translational modifications by effector modules such as bromodomains is a key step in many chromatin-related processes. Although effector-mediated recognition of single post-translation modifications is well characterized, combinatorial readout of histones bearing multiple modifications is poorly understood. Here, a distinct mechanism of combinatorial readout for the mouse TAF1 homologue Brdt, a testis-specific member of the BET protein family, is reported.
- Jeanne Morinière
- Sophie Rousseaux
- Carlo Petosa
