Nature Search

Uncertainty-aware ensemble of foundation models differentiates glioblastoma from its mimics

Distinguishing glioblastoma and primary central nervous system lymphoma (PCNSL) remains challenging due to their overlapping pathology features. Here, the authors develop a computational tool, PICTURE, for differentiating similar pathological features enabling improved diagnosis of CNS tumours.

Junhan Zhao
Shih-Yen Lin
Kun-Hsing Yu
ResearchOpen Access29 Sept 2025
Nature Communications

Volume: 16, P: 1-16
DDHD2 provides a flux of saturated fatty acids for neuronal energy and function

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

Saber H. Saber
Nyakuoy Yak
Merja Joensuu
ResearchOpen Access30 Sept 2025
Nature Metabolism

P: 1-25
Density-dependent network structuring within and across wild animal systems

The number of individuals in a given space influences animal interactions and network dynamics. Here the authors identify general rules underlying density dependence in animal networks and reveal some fundamental differences between spatial and social dynamics.

Gregory F. Albery
Daniel J. Becker
Shweta Bansal
Research04 Sept 2025
Nature Ecology & Evolution

P: 1-12
Advancing rheumatic disease care through generative artificial intelligence

Generative artificial intelligence promises to reshape clinical care in rheumatology by supporting diagnostic reasoning, treatment planning and patient communication. Yet its potential rests on careful validation, transparent integration and thoughtful collaboration that strengthens, rather than substitutes, the human expertise central to patient care.

Arjun Mahajan
David W. Bates
Jeffrey A. Sparks
Comments & Opinion13 Oct 2025
Nature Reviews Rheumatology

P: 1-2
Linkage of Rieger syndrome to the region of the epidermal growth factor gene on chromosome 4

Jeffrey C. Murray
Steven R. Bennett
Kenneth H. Buetow
Research01 Sept 1992
Nature Genetics

Volume: 2, P: 46-49
Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase

Mehran F. Moghaddam
David F. Grant
Bruce D. Hammock
Research01 May 1997
Nature Medicine

Volume: 3, P: 562-566
Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk

Analyses of genome and exome sequencing data identify rare coding and structural variants associated with atrial fibrillation and highlight genetic links between atrial fibrillation and cardiomyopathies.

Seung Hoan Choi
Sean J. Jurgens
Patrick T. Ellinor
Research06 Mar 2025
Nature Genetics

Volume: 57, P: 548-562
The NMR structure of the inhibited catalytic domain of human stromelysin–1

Paul R. Gooley
John F. O'Connell
Bruce A. Johnson
Research01 Feb 1994
Nature Structural Biology

Volume: 1, P: 111-118
Insecticide preservation policy: To be or not Bt

Jeffrey L. Fox
Research01 Jun 1996
Nature Biotechnology

Volume: 14, P: 697-698
“Nitty-gritty” FDA guidelines wanted sooner not later

Jeffrey L. Fox
Research01 Jun 1996
Nature Biotechnology

Volume: 14, P: 698
Towards a reference cell atlas of liver diversity over the human lifespan

This Roadmap presents and outlines the creation of the Human Liver Cell Atlas as a reference map and resource for the liver community, providing an overview of the steps needed to build the atlas, as well as outlining the major challenges and potential of this venture.

Sarah A. Taylor
Gary D. Bader
Mei Zhen
Reviews13 Oct 2025
Nature Reviews Gastroenterology & Hepatology

P: 1-13
Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Mutagenic deamination of cytosine residues in DNA

Bruce K. Duncan
Jeffrey H. Miller
Research09 Oct 1980
Nature

Volume: 287, P: 560-561
Neural basis of saccade target selection in frontal eye field during visual search

Jeffrey D. Schall
Doug P. Hanes
Research02 Dec 1993
Nature

Volume: 366, P: 467-469
¹⁰Be in island-arc volcanoes and implications for subduction

Louis Brown
Jeffrey Klein
Fouad Tera
Research21 Oct 1982
Nature

Volume: 299, P: 718-720
UCS says EPA Bts around the bush

Jeffrey L Fox
Research01 Apr 1998
Nature Biotechnology

Volume: 16, P: 324
Rhône-Poulenc rounds up DeKalb and Monsanto

Jeffrey L Fox
Research01 Dec 1997
Nature Biotechnology

Volume: 15, P: 1332
HeLa cells secrete α subunit of glycoprotein tropic hormones

JEFFREY M. LIEBLICH
BRUCE D. WEINTRAUB
J. C. ROBINSON
Research08 Apr 1976
Nature

Volume: 260, P: 530-532
Secretion of hCG-α subunit and hCG by HeLa strains

JEFFREY M. LIEBLICH
BRUCE D. WEINTRAUB
RODY P. Cox
Research24 Feb 1977
Nature

Volume: 265, P: 746
Estimation of reference curves for brain atrophy and analysis of robustness to machine effects

Elodie Piot
Félix Renard
Maria Luisa Mandelli
ResearchOpen Access03 Oct 2025
Scientific Reports

Volume: 15, P: 1-21
Association between self-reported multimorbidity and longitudinal brain Aβ deposition in Alzheimer’s disease

Whether multimorbidity accelerates brain Aβ deposition in humans remains largely unknown. Here, the authors demonstrate that higher self-reported multimorbidity burden predicts increased brain Aβ accumulation rates in the ADNI cohort.

Xian-Le Bu
Wei Zhu
Kristin Fargher
ResearchOpen Access01 Jul 2025
Nature Communications

Volume: 16, P: 1-12
A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies

MultiSTAAR provides a general and flexible statistical framework for functionally informed multi-trait rare variant analysis of biobank-scale sequencing studies by jointly analyzing multiple traits and incorporating annotation information.

Xihao Li
Han Chen
Xihong Lin
Research07 Feb 2025
Nature Computational Science

Volume: 5, P: 125-143
Synthesis of hepatitis B surface and core antigens in E. coli

Jeffrey C. Edman
Robert A. Hallewell
William J. Rutter
Research11 Jun 1981
Nature

Volume: 291, P: 503-506
BIO calls for doubled NIH budget

Jeffrey L. Fox
Research01 Mar 1998
Nature Biotechnology

Volume: 16, P: 230-231
NIH looks inward and outside for ways to help minorities

Jeffrey Mervis
Research17 Sept 1992
Nature

Volume: 359, P: 186
Origins of homochirality

Jeffrey L. Bada
News & Views13 Apr 1995
Nature

Volume: 374, P: 594-595
Reforms will ease patenting of biotechnology therapeutics

Jeffrey L. Fox
News01 Feb 1995
Nature Medicine

Volume: 1, P: 104
Aberrant activation of TCL1A promotes stem cell expansion in clonal haematopoiesis

Using data from a single time point, passenger-approximated clonal expansion rate (PACER) estimates the fitness of common driver mutations that lead to clonal haematopoiesis and identifies TCL1A activation as a mediator of clonal expansion.

Joshua S. Weinstock
Jayakrishnan Gopakumar
Siddhartha Jaiswal
Research12 Apr 2023
Nature

Volume: 616, P: 755-763
New insights into the genetic etiology of Alzheimer’s disease and related dementias

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

Céline Bellenguez
Fahri Küçükali
Jean-Charles Lambert
ResearchOpen Access04 Apr 2022
Nature Genetics

Volume: 54, P: 412-436
Assessing the contribution of rare variants to complex trait heritability from whole-genome sequence data

Analysis of whole-genome sequences of 25,465 individuals of European ancestry shows that rare variants contribute substantially to the heritability of height and body mass index.

Pierrick Wainschtein
Deepti Jain
Peter M. Visscher
Research07 Mar 2022
Nature Genetics

Volume: 54, P: 263-273
Chromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices

The influence of X chromosome genetic variation on blood lipids and coronary heart disease (CHD) is not well understood. Here, the authors analyse X chromosome sequencing data across 65,322 multi-ancestry individuals, identifying associations of the Xq23 locus with lipid changes and reduced risk of CHD and diabetes mellitus.

Pradeep Natarajan
Akhil Pampana
Gina M. Peloso
ResearchOpen Access12 Apr 2021
Nature Communications

Volume: 12, P: 1-14
Variant-specific inflation factors for assessing population stratification at the phenotypic variance level

Pooling participant-level genetic data into a single analysis can result in variance stratification, reducing statistical performance. Here, the authors develop variant-specific inflation factors to assess variance stratification and apply this to pooled individual-level data from whole genome sequencing.

Tamar Sofer
Xiuwen Zheng
Kenneth M. Rice
ResearchOpen Access09 Jun 2021
Nature Communications

Volume: 12, P: 1-14
The “Minimum Information about an ENvironmental Sequence” (MIENS) specification

Pelin Yilmaz
Renzo Kottmann
Frank Oliver Glöckner
ResearchOpen Access15 Nov 2010
Nature Precedings

P: 1
Enrichment of molecular antenna triplets amplifies upconverting nanoparticle emission

Lanthanide-doped upconverting nanoparticles exhibiting a 33,000 times increase in brightness and a 100 times increase in efficiency over bare upconverting nanoparticles are demonstrated. The findings are relevant in fields from solar energy to biophotonics.

David J. Garfield
Nicholas J. Borys
P. James Schuck
Research23 Apr 2018
Nature Photonics

Volume: 12, P: 402-407
The “Minimum Information about an ENvironmental Sequence” (MIENS) specification

Peter Sterk
Jeffrey Gordon
Doyle Ward
ResearchOpen Access16 Nov 2010
Nature Precedings

P: 1
Visual feature selectivity in frontal eye fields induced by experience in mature macaques

Narcisse P. Bichot
Jeffrey D. Schall
Kirk G. Thompson
Research20 Jun 1996
Nature

Volume: 381, P: 697-699
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

Large genome-wide meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.

Brian W. Kunkle
Benjamin Grenier-Boley
Margaret A. Pericak-Vance
Research28 Feb 2019
Nature Genetics

Volume: 51, P: 414-430
Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A₄

Bruce D. Levy
George T. De Sanctis
Charles N. Serhan
Research12 Aug 2002
Nature Medicine

Volume: 8, P: 1018-1023
The origin and evolution of maize in the Southwestern United States

Maize originated in southern Mexico from domestication of the wild grass teosinte, and diffused throughout the Americas. Sequenced DNA from archaeological samples spanning 6,000 years, documents the diffusion route and reveals the genes that were specifically selected for climatic and cultural adaptation to the US Southwest.

Rute R. da Fonseca
Bruce D. Smith
M. Thomas P. Gilbert
Research08 Jan 2015
Nature Plants

Volume: 1, P: 1-5
Differentiation and reversal of malignant changes in colon cancer through PPARγ

Pasha Sarraf
Elisabetta Mueller
Bruce M. Spiegelman
Research01 Sept 1998
Nature Medicine

Volume: 4, P: 1046-1052
1526 THE EFFECT OF A NISSEN FUNDOPLICATION ON INFANTS WITH CHRONIC LUNG DISEASE (CLD)

Bruce P Sindel
M Jeffrey Maisels
Stephen R Karl
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 365
1525 GASTROESOPHAGEAL REFLUX (GER) TO THE PROXIMAL ESOPHAGUS IN NEONATES WITH BRONCHOPULMONARY DYSPLASIA

Bruce D Sindel
M Jeffrey Malsels
Thomas V N Ballantine
Research01 Apr 1985
Pediatric Research

Volume: 19, P: 365
A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies

STAARpipeline is a comprehensive framework for flexible and scalable rare-variant association analysis using whole-genome sequencing data and annotation information.

Zilin Li
Xihao Li
Xihong Lin
Research27 Oct 2022
Nature Methods

Volume: 19, P: 1599-1611
Lukewarm reception for US biotech proposals

Jeffrey L. Fox
Research01 Jun 2000
Nature Biotechnology

Volume: 18, P: 590-591
Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using whole genome sequencing data.

Margaret Sunitha Selvaraj
Xihao Li
Pradeep Natarajan
ResearchOpen Access11 Oct 2022
Nature Communications

Volume: 13, P: 1-18
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage

This Resource describes data, code and tools developed for the Human Reference Atlas and the Human BioMolecular Atlas Program for building and navigating a multiscale human atlas.

Katy Börner
Philip D. Blood
Bruce W. Herr II
ResearchOpen Access13 Mar 2025
Nature Methods

Volume: 22, P: 845-860
Aptamer-based multiplexed proteomic technology for biomarker discovery

Larry Gold
Deborah Ayers
Dom Zichi
ResearchOpen Access14 Jun 2010
Nature Precedings

P: 1
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Genome-wide analyses identify common variants associated with 11 distinct neuropathology endophenotypes, providing insights into the mechanisms underlying the genetic risk of Alzheimer’s disease and related dementias.

Lincoln M. P. Shade
Yuriko Katsumata
David W. Fardo
ResearchOpen Access08 Oct 2024
Nature Genetics

Volume: 56, P: 2407-2421
Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele

Here, the authors leverage whole-genome sequencing from >88,000 diverse individuals to uncover 18 BMI-related genetic signals, including novel variants in participants of African genetic ancestry, highlighting the value of diversity in genetic discovery.

Xinruo Zhang
Jennifer A. Brody
Anne E. Justice
ResearchOpen Access11 Apr 2025
Nature Communications

Volume: 16, P: 1-15
Self-reactive γδ T cells are eliminated in the thymus

Alexander L. Dent
Louis A. Matis
Stephen M. Hedrick
Research22 Feb 1990
Nature

Volume: 343, P: 714-719

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