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Showing 1–3 of 3 results
Advanced filters: Author: Jeffrey Makings Clear advanced filters

  • By characterizing APOB-reactive CD4+ T cells in patients with atherosclerosis, Roy et al. identify effector regulatory T (eTreg) cells as the predominant autoreactive subset. These APOB-specific eTreg cells are clonally expanded, express the plaque-homing receptor CXCR6 and progressively lose their regulatory phenotype as disease severity increases.

    • Payel Roy
    • Anusha Bellapu
    • Klaus Ley
    Research
    Nature Cardiovascular Research
    Volume: 4, P: 841-856

  • In inflammation, some regulatory T (Treg) cells lose FoxP3 expression and become exTreg cells. Ley and colleagues mapped mouse Treg and exTreg cell transcriptomes to a human peripheral blood mononuclear cell single-cell RNA-sequencing dataset with surface markers (CITE-seq) and identify human exTreg cells as cytotoxic CD4+ T cells.

    • Antoine Freuchet
    • Payel Roy
    • Klaus Ley
    Research
    Nature Immunology
    Volume: 24, P: 1748-1761